{"id":34586,"date":"2019-12-13T04:30:39","date_gmt":"2019-12-13T03:30:39","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=34586"},"modified":"2019-12-13T04:30:39","modified_gmt":"2019-12-13T03:30:39","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-regulacion-epigenetica-de-la-alta-produccion-de-citocinas-proinflamatorias-inducidas-por-glucosa-en-monocitos-por-la-curcumina","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=34586","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abRegulaci\u00f3n epigen\u00e9tica de la alta producci\u00f3n de citocinas proinflamatorias inducidas por glucosa en monocitos por la curcumina\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/---MyDu1zKdw\/XfO-fSEyFaI\/AAAAAAAAZJ0\/_zKAhIcC03sjZLSro_sWD3fIwRqRvabPwCLcBGAsYHQ\/s1600\/Journal_Nutritional%2BBiochemistry.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/---MyDu1zKdw\/XfO-fSEyFaI\/AAAAAAAAZJ0\/_zKAhIcC03sjZLSro_sWD3fIwRqRvabPwCLcBGAsYHQ\/s320\/Journal_Nutritional%2BBiochemistry.jpg\" width=\"240\" height=\"320\" border=\"0\" data-original-width=\"576\" data-original-height=\"768\" \/><\/a>Yun, J. M., Jialal, I., &amp; Devaraj, S. (2011).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3010508\/\">Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin.<\/a>\u00a0<i>The Journal of nutritional biochemistry<\/i>, 22(5), 450-458.<\/p>\n<p>FONDO: La diabetes es un estado proinflamatorio. Anteriormente hemos demostrado un aumento de las citocinas proinflamatorias de monocitos en pacientes con diabetes tipo 1 y tipo 2. La glucosa alta induce citocinas proinflamatorias a trav\u00e9s de cambios epigen\u00e9ticos. Se sabe que la curcumina, un polifenol responsable del color amarillo de la especia c\u00farcuma, ejerce una potente actividad antiinflamatoria in vitro. Estudios recientes indican que puede regular la remodelaci\u00f3n de la cromatina al inhibir la acetilaci\u00f3n de histonas.\u00a0<\/p>\n<p>OBJETIVO: En este estudio, nuestro objetivo fue evaluar el efecto de la curcumina sobre la acetilaci\u00f3n de histonas y la secreci\u00f3n de citocinas proinflamatorias en condiciones de glucosa alta en monocitos humanos.\u00a0<\/p>\n<p>M\u00c9TODO Y MEDIDAS DE RESULTADOS: Se cultivaron c\u00e9lulas monoc\u00edticas humanas (THP-1) en presencia de condiciones de manitol (control osmolar, manitol) o normogluc\u00e9mico (NG, 5.5 mmol \/ L glucosa) o hipergluc\u00e9mico (HG, 25 mmol \/ L glucosa) en ausencia o presencia de curcumina ( 1) 5-12.5 \u03bcM) durante 72 h. El nivel de citoquinas, la transactivaci\u00f3n del factor nuclear \u03baB (NF-\u03baB), la actividad de las histona desacetilasas (HDAC), la actividad de las histonas acetilasas (HAT) se midieron mediante transferencias Western, reacci\u00f3n cuantitativa en cadena de la transcriptasa inversa-polimerasa, ensayo inmunoabsorbente ligado a enzimas, tinci\u00f3n de inmunofluorescencia. HG indujo significativamente la acetilaci\u00f3n de histonas, la actividad de NF-\u03baB y la liberaci\u00f3n de citocinas proinflamatorias (interleucina 6, factor de necrosis tumoral \u03b1 y MCP-1) de las c\u00e9lulas THP-1.\u00a0<\/p>\n<p>RESULTADOS: La curcumina suprimi\u00f3 la uni\u00f3n de NF-\u03baB y la liberaci\u00f3n de citocinas en las c\u00e9lulas THP-1. Adem\u00e1s, dado que la histona acetiltransferasa p300 es un coactivador de NF-\u03baB, examinamos su acetilaci\u00f3n. El tratamiento con curcumina tambi\u00e9n redujo significativamente la actividad de HAT, el nivel de p300 y la expresi\u00f3n del gen CBP \/ p300 acetilado, y la expresi\u00f3n de HDAC2 inducida por la curcumina.\u00a0<\/p>\n<p>CONCLUSIONES: Estos resultados indican que la curcumina disminuye la producci\u00f3n de citocinas inducida por HG en monocitos a trav\u00e9s de cambios epigen\u00e9ticos que involucran NF-\u03baB. En conclusi\u00f3n, la suplementaci\u00f3n con curcumina al reducir la inflamaci\u00f3n vascular puede prevenir complicaciones diab\u00e9ticas.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yun, J. M., Jialal, I., &amp; Devaraj, S. (2011).\u00a0Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin.\u00a0The Journal of nutritional biochemistry, 22(5), 450-458. FONDO: La diabetes es un estado proinflamatorio. Anteriormente hemos demostrado un aumento de las citocinas proinflamatorias de monocitos en pacientes con diabetes tipo 1 y tipo 2. La glucosa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-34586","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Regulaci\u00f3n epigen\u00e9tica de la alta producci\u00f3n de citocinas proinflamatorias inducidas por glucosa en monocitos por la curcumina&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=34586\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Regulaci\u00f3n epigen\u00e9tica de la alta producci\u00f3n de citocinas proinflamatorias inducidas por glucosa en monocitos por la curcumina&quot; -\" \/>\n<meta property=\"og:description\" content=\"Yun, J. M., Jialal, I., &amp; Devaraj, S. (2011).\u00a0Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin.\u00a0The Journal of nutritional biochemistry, 22(5), 450-458. FONDO: La diabetes es un estado proinflamatorio. Anteriormente hemos demostrado un aumento de las citocinas proinflamatorias de monocitos en pacientes con diabetes tipo 1 y tipo 2. La glucosa [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=34586\" \/>\n<meta property=\"article:published_time\" content=\"2019-12-13T03:30:39+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/---MyDu1zKdw\/XfO-fSEyFaI\/AAAAAAAAZJ0\/_zKAhIcC03sjZLSro_sWD3fIwRqRvabPwCLcBGAsYHQ\/s320\/Journal_Nutritional%2BBiochemistry.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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M., Jialal, I., &amp; Devaraj, S. (2011).\u00a0Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin.\u00a0The Journal of nutritional biochemistry, 22(5), 450-458. FONDO: La diabetes es un estado proinflamatorio. Anteriormente hemos demostrado un aumento de las citocinas proinflamatorias de monocitos en pacientes con diabetes tipo 1 y tipo 2. 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