{"id":34591,"date":"2019-12-13T06:30:53","date_gmt":"2019-12-13T05:30:53","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=34591"},"modified":"2019-12-13T06:30:53","modified_gmt":"2019-12-13T05:30:53","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-los-tratamientos-combinados-con-luteolina-y-fisetina-mejoran-los-efectos-antiinflamatorios-en-las-celulas-thp-1-tratadas-con-al","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=34591","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLos tratamientos combinados con luteolina y fisetina mejoran los efectos antiinflamatorios en las c\u00e9lulas THP-1 tratadas con alto contenido de glucosa a trav\u00e9s de la regulaci\u00f3n de histona acetiltransferasa \/ histona desacetilasa \u00ab"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-WFAFZEvDskw\/XfPPK5afEzI\/AAAAAAAAZKE\/Ur7jJjLUpXsDgCf6pvrlxSQxpkrWS4eyACLcBGAsYHQ\/s1600\/Journal_Medicinal_Food2.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-WFAFZEvDskw\/XfPPK5afEzI\/AAAAAAAAZKE\/Ur7jJjLUpXsDgCf6pvrlxSQxpkrWS4eyACLcBGAsYHQ\/s1600\/Journal_Medicinal_Food2.jpg\" border=\"0\" data-original-width=\"197\" data-original-height=\"256\" \/><\/a>Kim, A., &amp; Yun, J. M. (2017).\u00a0<a href=\"https:\/\/www.liebertpub.com\/doi\/abs\/10.1089\/jmf.2017.3968\">Combination treatments with luteolin and fisetin enhance anti-inflammatory effects in high glucose-treated THP-1 cells through histone acetyltransferase\/histone deacetylase regulation.<\/a><i>\u00a0Journal of medicinal food<\/i>, 20(8), 782-789.<\/p>\n<p>FONDO: La hiperglucemia conduce a la diabetes y sus complicaciones diab\u00e9ticas.\u00a0<\/p>\n<p>OBJETIVO: En este estudio, investigamos los efectos sin\u00e9rgicos de la luteolina y la fisetina en la secreci\u00f3n de citocinas proinflamatorias y su regulaci\u00f3n epigen\u00e9tica subyacente en monocitos humanos expuestos a concentraciones hipergluc\u00e9micas (HG).\u00a0<\/p>\n<p>MATERIALES Y M\u00c9TODO: Las c\u00e9lulas monoc\u00edticas humanas (THP-1) se cultivaron en condiciones controladas (manitol 14,5 mM), normogluc\u00e9mico (glucosa 5,5 mM) o HG (glucosa 20 mM) en ausencia o presencia de los dos fitoqu\u00edmicos durante 48 h.\u00a0<\/p>\n<p>RESULTADOS: Considerando que las condiciones de HG indujeron significativamente la acetilaci\u00f3n de histonas, la activaci\u00f3n del factor nuclear kappa B (NF- \u03ba B), la interleucina 6 y la liberaci\u00f3n del factor de necrosis tumoral- \u03b1 de las c\u00e9lulas THP-1; tratamientos combinados con los dos fitoqu\u00edmicos (fisetina 500 nM y l \u03bcM y 500 nM luteolina) suprimieron la actividad de NF- \u03ba B y la liberaci\u00f3n de citoquinas inflamatorias. Fisetina, luteolina, y sus tratamientos de combinaci\u00f3n tambi\u00e9n disminuyeron significativamente la actividad de la acetiltransferasa de histona, un conocido NF- \u03ba coactivador B; inhibici\u00f3n de la producci\u00f3n reactiva de especies de ox\u00edgeno; y expresiones activadas de sirtuin (SIRT) 1 y caja de forkhead O3a (FOXO3a) ( P \u2009&lt;0,05). Por lo tanto, los tratamientos de combinaci\u00f3n con los dos fitoqu\u00edmicos inhibieron HG producci\u00f3n de citoquinas condici\u00f3n inducida en monocitos, a trav\u00e9s de cambios epigen\u00e9ticos que implican NF- \u03ba B activaci\u00f3n.\u00a0<\/p>\n<p>CONCLUSI\u00d3N: Por lo tanto, sugerimos que los tratamientos combinados con luteolina y fisetina pueden ser un candidato potencial para el tratamiento y la prevenci\u00f3n de la diabetes y sus complicaciones.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kim, A., &amp; Yun, J. M. (2017).\u00a0Combination treatments with luteolin and fisetin enhance anti-inflammatory effects in high glucose-treated THP-1 cells through histone acetyltransferase\/histone deacetylase regulation.\u00a0Journal of medicinal food, 20(8), 782-789. FONDO: La hiperglucemia conduce a la diabetes y sus complicaciones diab\u00e9ticas.\u00a0 OBJETIVO: En este estudio, investigamos los efectos sin\u00e9rgicos de la luteolina y la fisetina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-34591","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Los tratamientos combinados con luteolina y fisetina mejoran los efectos antiinflamatorios en las c\u00e9lulas THP-1 tratadas con alto contenido de glucosa a trav\u00e9s de la regulaci\u00f3n de histona acetiltransferasa \/ histona desacetilasa &quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=34591\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Los tratamientos combinados con luteolina y fisetina mejoran los efectos antiinflamatorios en las c\u00e9lulas THP-1 tratadas con alto contenido de glucosa a trav\u00e9s de la regulaci\u00f3n de histona acetiltransferasa \/ histona desacetilasa &quot; -\" \/>\n<meta property=\"og:description\" content=\"Kim, A., &amp; Yun, J. M. (2017).\u00a0Combination treatments with luteolin and fisetin enhance anti-inflammatory effects in high glucose-treated THP-1 cells through histone acetyltransferase\/histone deacetylase regulation.\u00a0Journal of medicinal food, 20(8), 782-789. 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