{"id":34604,"date":"2019-12-14T03:30:59","date_gmt":"2019-12-14T02:30:59","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=34604"},"modified":"2019-12-14T03:30:59","modified_gmt":"2019-12-14T02:30:59","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-eficacia-neuropsicofarmacoterapeutica-de-la-curcumina-en-el-paradigma-experimental-de-los-trastornos-del-espectro-autista","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=34604","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEficacia neuropsicofarmacoterap\u00e9utica de la curcumina en el paradigma experimental de los trastornos del espectro autista\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-mv1Yci43hUE\/XfPYG59IGEI\/AAAAAAAAZKk\/3X4zUr6WHb0gr0iRFlzVjTaMAVApSCvowCLcBGAsYHQ\/s1600\/Life_Sciences.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-mv1Yci43hUE\/XfPYG59IGEI\/AAAAAAAAZKk\/3X4zUr6WHb0gr0iRFlzVjTaMAVApSCvowCLcBGAsYHQ\/s320\/Life_Sciences.jpg\" width=\"240\" height=\"320\" border=\"0\" data-original-width=\"576\" data-original-height=\"768\" \/><\/a>Bhandari, R., &amp; Kuhad, A. (2015).\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0024320515300151\">Neuropsychopharmacotherapeutic efficacy of curcumin in experimental paradigm of autism spectrum disorders<\/a>.\u00a0<i>Life sciences<\/i>, 141, 156-169.<\/p>\n<p>OBJETIVO: La respuesta neuroinflamatoria desencadenada por la estimulaci\u00f3n de las metaloproteinasas de la matriz desempe\u00f1a un papel fundamental en el desarrollo del fenotipo autista. Las MMP estimulan la liberaci\u00f3n de citocinas inflamatorias junto con d\u00e9ficits mitocondriales que finalmente conducen a la disfunci\u00f3n neuronal y precipitan los s\u00edntomas autistas. El objetivo del presente estudio fue explorar la eficacia neuropsicofarmacoterap\u00e9utica de la curcumina en el paradigma experimental de los trastornos del espectro autista.<\/p>\n<p>MATERIALES Y M\u00c9TODOS: Se infundi\u00f3 \u00e1cido propanoico 1 M (4 \u03bcl) durante 10 minutos en la porci\u00f3n anterior del caudoputamen para inducir un comportamiento autista en ratas. La curcumina (50, 100 y 200 mg \/ kg) se administr\u00f3 por v\u00eda oral a partir del segundo d\u00eda de la cirug\u00eda y continu\u00f3 hasta el d\u00eda 28. Las ratas se probaron para varios paradigmas neuroconductuales como la interacci\u00f3n social, estereotipia, actividad locomotora, ansiedad, novedad, depresi\u00f3n, aprendizaje espacial y memoria, as\u00ed como para el comportamiento repetitivo y generalizado. Adem\u00e1s, tambi\u00e9n se llevaron a cabo pruebas bioqu\u00edmicas de estr\u00e9s oxidativo, complejos mitocondriales, TNF-\u03b1 y MMP-9.<\/p>\n<p>RESULTADOS CLAVE: La inyecci\u00f3n intracerebroventricular de \u00e1cido propanoico produjo d\u00e9ficits neurol\u00f3gicos, sensoriales, conductuales, bioqu\u00edmicos y moleculares que se evaluaron como endofenotipo de trastornos del espectro autista. El tratamiento regular con curcumina durante cuatro semanas significativamente y dosis dependientes restauraron los cambios neurol\u00f3gicos, conductuales, bioqu\u00edmicos y moleculares asociados con el fenotipo autista en ratas.<\/p>\n<p>SIGNIFICADO. El principal hallazgo del estudio es que la curcumina restableci\u00f3 el n\u00facleo y los s\u00edntomas asociados del fenotipo autista al suprimir el estr\u00e9s oxidativo-nitrosativo, la disfunci\u00f3n mitocondrial, TNF-\u03b1 y MMP-9 en el autismo inducido por PPA en ratas. Por lo tanto, la curcumina se puede desarrollar como un posible complemento neuropsicofarmacoterap\u00e9utico para los trastornos del espectro autista (TEA).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bhandari, R., &amp; Kuhad, A. (2015).\u00a0Neuropsychopharmacotherapeutic efficacy of curcumin in experimental paradigm of autism spectrum disorders.\u00a0Life sciences, 141, 156-169. OBJETIVO: La respuesta neuroinflamatoria desencadenada por la estimulaci\u00f3n de las metaloproteinasas de la matriz desempe\u00f1a un papel fundamental en el desarrollo del fenotipo autista. Las MMP estimulan la liberaci\u00f3n de citocinas inflamatorias junto con d\u00e9ficits mitocondriales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-34604","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Eficacia neuropsicofarmacoterap\u00e9utica de la curcumina en el paradigma experimental de los trastornos del espectro autista&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=34604\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Eficacia neuropsicofarmacoterap\u00e9utica de la curcumina en el paradigma experimental de los trastornos del espectro autista&quot; -\" \/>\n<meta property=\"og:description\" content=\"Bhandari, R., &amp; Kuhad, A. (2015).\u00a0Neuropsychopharmacotherapeutic efficacy of curcumin in experimental paradigm of autism spectrum disorders.\u00a0Life sciences, 141, 156-169. OBJETIVO: La respuesta neuroinflamatoria desencadenada por la estimulaci\u00f3n de las metaloproteinasas de la matriz desempe\u00f1a un papel fundamental en el desarrollo del fenotipo autista. Las MMP estimulan la liberaci\u00f3n de citocinas inflamatorias junto con d\u00e9ficits mitocondriales [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=34604\" \/>\n<meta property=\"article:published_time\" content=\"2019-12-14T02:30:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-mv1Yci43hUE\/XfPYG59IGEI\/AAAAAAAAZKk\/3X4zUr6WHb0gr0iRFlzVjTaMAVApSCvowCLcBGAsYHQ\/s320\/Life_Sciences.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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