{"id":34613,"date":"2019-12-16T00:30:47","date_gmt":"2019-12-15T23:30:47","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=34613"},"modified":"2019-12-16T00:30:47","modified_gmt":"2019-12-15T23:30:47","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-el-efecto-quimiopreventivo-del-compuesto-dietetico-kaempferol-en-la-linea-celular-de-cancer-de-mama-humano-mcf-7-depende-de-la","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=34613","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl efecto quimiopreventivo del compuesto diet\u00e9tico Kaempferol en la l\u00ednea celular de c\u00e1ncer de mama humano MCF-7 depende de la inhibici\u00f3n de la captaci\u00f3n celular de glucosa\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-Am8NizQId94\/XfPbspjQPYI\/AAAAAAAAZK8\/tN-KDKhEEKEREvXMOwF5G6Ogo6J__kKBACLcBGAsYHQ\/s1600\/Nutrition_Cancer.png\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-Am8NizQId94\/XfPbspjQPYI\/AAAAAAAAZK8\/tN-KDKhEEKEREvXMOwF5G6Ogo6J__kKBACLcBGAsYHQ\/s1600\/Nutrition_Cancer.png\" border=\"0\" data-original-width=\"200\" data-original-height=\"280\" \/><\/a>Azevedo, C., Correia-Branco, A., Ara\u00fajo, J. R., Guimar\u00e3es, J. T., Keating, E., &amp; Martel, F. (2015).\u00a0<a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/01635581.2015.1002625?src=recsys\">The chemopreventive effect of the dietary compound kaempferol on the MCF-7 human breast cancer cell line is dependent on inhibition of glucose cellular uptake<\/a>.\u00a0<i>Nutrition and cancer,<\/i>\u00a067(3), 504-513.<\/p>\n<p>OBJETIVO: Nuestro objetivo fue investigar el efecto de varios polifenoles de la dieta en la absorci\u00f3n de glucosa por las c\u00e9lulas de c\u00e1ncer de mama.\u00a0<\/p>\n<p>RESULTADOS: La absorci\u00f3n de 3 H-desoxi-D-glucosa ( 3 H-DG) por las c\u00e9lulas MCF-7 fue dependiente del tiempo, saturable e inhibida por la citocalasina B m\u00e1s floridzina. A corto plazo (26 min), la miricetina, la crisina, la geniste\u00edna, el resveratrol, el kaempferol y el xantohumol (10\u2013100 \u00b5M) inhibieron la captaci\u00f3n de 3 H-DG.\u00a0<\/p>\n<p>Se encontr\u00f3 que el Kaempferol es el inhibidor m\u00e1s potente de la captaci\u00f3n de 3 H-DG [IC 50 de 4 \u00b5M (1.6\u20139.8)], comport\u00e1ndose como un inhibidor de tipo mixto. A largo plazo (24 h), el kaempferol (30 \u00b5M) tambi\u00e9n fue capaz de inhibir 3Absorci\u00f3n de H-DG, asociada con una disminuci\u00f3n del 40% en los niveles de ARNm de GLUT1. Curiosamente, kaempferol (100 \u00b5M) revel\u00f3 antiproliferativo (sulforhodamine B y 3Ensayos de incorporaci\u00f3n de H-timidina) y propiedades citot\u00f3xicas (determinaci\u00f3n de actividad extracelular de la lactato deshidrogenasa), que fueron imitadas por condiciones de glucosa extracelular baja (1 mM) y revertidas por condiciones de glucosa extracelular alta (20 mM).\u00a0<\/p>\n<p>Finalmente, la exposici\u00f3n de las c\u00e9lulas al kaempferol (30 \u00b5M) indujo un aumento en los niveles de lactato extracelular con el tiempo (a 731 \u00b1 32% de control despu\u00e9s de una exposici\u00f3n de 24 h), debido a la inhibici\u00f3n de la absorci\u00f3n celular de lactato mediada por MCT1.\u00a0<\/p>\n<p>CONCLUSI\u00d3N: En conclusi\u00f3n, el kaempferol inhibe potentemente la absorci\u00f3n de glucosa por las c\u00e9lulas MCF-7, aparentemente al disminuir la absorci\u00f3n de glucosa mediada por GLUT1. El efecto antiproliferativo y citot\u00f3xico del kaempferol en estas c\u00e9lulas parece depender de este efecto.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Azevedo, C., Correia-Branco, A., Ara\u00fajo, J. R., Guimar\u00e3es, J. T., Keating, E., &amp; Martel, F. (2015).\u00a0The chemopreventive effect of the dietary compound kaempferol on the MCF-7 human breast cancer cell line is dependent on inhibition of glucose cellular uptake.\u00a0Nutrition and cancer,\u00a067(3), 504-513. OBJETIVO: Nuestro objetivo fue investigar el efecto de varios polifenoles de la dieta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-34613","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El efecto quimiopreventivo del compuesto diet\u00e9tico Kaempferol en la l\u00ednea celular de c\u00e1ncer de mama humano MCF-7 depende de la inhibici\u00f3n de la captaci\u00f3n celular de glucosa&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=34613\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El efecto quimiopreventivo del compuesto diet\u00e9tico Kaempferol en la l\u00ednea celular de c\u00e1ncer de mama humano MCF-7 depende de la inhibici\u00f3n de la captaci\u00f3n celular de glucosa&quot; -\" \/>\n<meta property=\"og:description\" content=\"Azevedo, C., Correia-Branco, A., Ara\u00fajo, J. R., Guimar\u00e3es, J. T., Keating, E., &amp; Martel, F. (2015).\u00a0The chemopreventive effect of the dietary compound kaempferol on the MCF-7 human breast cancer cell line is dependent on inhibition of glucose cellular uptake.\u00a0Nutrition and cancer,\u00a067(3), 504-513. 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