{"id":34627,"date":"2019-12-16T06:30:33","date_gmt":"2019-12-16T05:30:33","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=34627"},"modified":"2019-12-16T06:30:33","modified_gmt":"2019-12-16T05:30:33","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-reutilizando-el-l-mentol-para-la-medicina-de-sistemas-y-la-terapeutica-del-cancer-el-l-mentol-induce-apoptosis-a-traves","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=34627","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00ab\u00bfReutilizando el L-mentol para la medicina de sistemas y la terap\u00e9utica del c\u00e1ncer? El L-mentol induce apoptosis a trav\u00e9s de la caspasa 10 y al suprimir HSP90\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-sS64r_H5VJE\/XfP2EpkAIqI\/AAAAAAAAZLk\/1lQ3k5G4jJ456Ikl3IXRJ5iVsBkO5We_ACLcBGAsYHQ\/s1600\/omics.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-sS64r_H5VJE\/XfP2EpkAIqI\/AAAAAAAAZLk\/1lQ3k5G4jJ456Ikl3IXRJ5iVsBkO5We_ACLcBGAsYHQ\/s1600\/omics.jpg\" border=\"0\" data-original-width=\"197\" data-original-height=\"256\" \/><\/a>Faridi, U., Dhawan, S. S., Pal, S., Gupta, S., Shukla, A. K., Darokar, M. P., &#8230; &amp; Shasany, A. K. (2016). <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4739352\/\">Repurposing L-Menthol for Systems Medicine and Cancer Therapeutics? L-Menthol Induces Apoptosis through Caspase 10 and by Suppressing HSP90<\/a>.\u00a0<i>Omics: a journal of integrative biology<\/i>, 20(1), 53-64.<\/p>\n<p>El objetivo del presente estudio fue reutilizar el L-mentol, que se usa con frecuencia en la salud oral y las formulaciones t\u00f3picas, para la terap\u00e9utica del c\u00e1ncer.\u00a0<\/p>\n<p>En este art\u00edculo, sostenemos que los monoterpenos como el L-mentol podr\u00edan ofrecer verdaderos potenciales en la medicina de sistemas, por ejemplo, como compuestos anticancer\u00edgenos m\u00e1s baratos.\u00a0<\/p>\n<p>Se ha demostrado que otros monoterpenos como el limoneno, el alcohol peril\u00edlico y el geraniol inducen apoptosis en varias l\u00edneas celulares de c\u00e1ncer, pero sus mecanismos de acci\u00f3n a\u00fan no se han dilucidado por completo. Anteriormente, demostramos que el L-mentol modula la polimerizaci\u00f3n de la tubulina y la apoptosis para inhibir la proliferaci\u00f3n de c\u00e9lulas cancerosas.\u00a0<\/p>\n<p>En el presente informe, utilizamos un microarray de genes relacionado con la apoptosis junto con an\u00e1lisis prote\u00f3micos, as\u00ed como interpretaciones in silico, para estudiar la modulaci\u00f3n de la expresi\u00f3n g\u00e9nica en la l\u00ednea celular de adenocarcinoma humano Caco-2 en respuesta al tratamiento con L-mentol. El an\u00e1lisis de microarrays identific\u00f3 la caspasa 10 como la caspasa iniciadora importante, en lugar de la caspasa 8.\u00a0<\/p>\n<p>Los an\u00e1lisis prote\u00f3micos mostraron una regulaci\u00f3n negativa de la prote\u00edna HSP90 (tambi\u00e9n corroborada por su baja abundancia de transcripci\u00f3n), que a su vez indicaba la inhibici\u00f3n de la v\u00eda de supervivencia mediada por AKT, la liberaci\u00f3n de pro -Factor apopt\u00f3tico BAD del complejo BAD y BCLxL, adem\u00e1s de la regulaci\u00f3n de otros factores relacionados con la apoptosis. Basado en la combinaci\u00f3n de microarrays, prote\u00f3mica y datos in silico, aqu\u00ed se presenta por primera vez una v\u00eda de se\u00f1alizaci\u00f3n para la apoptosis inducida por L-mentol.\u00a0<\/p>\n<p>Estos an\u00e1lisis de datos y literatura tienen implicaciones significativas para \u00abreutilizar\u00bb el L-mentol m\u00e1s all\u00e1 de la medicina oral, y en la comprensi\u00f3n del modo de acci\u00f3n de los monoterpenos de origen vegetal hacia el desarrollo de medicamentos anticancer\u00edgenos m\u00e1s baratos en el futuro.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Faridi, U., Dhawan, S. S., Pal, S., Gupta, S., Shukla, A. K., Darokar, M. P., &#8230; &amp; Shasany, A. K. (2016). Repurposing L-Menthol for Systems Medicine and Cancer Therapeutics? L-Menthol Induces Apoptosis through Caspase 10 and by Suppressing HSP90.\u00a0Omics: a journal of integrative biology, 20(1), 53-64. El objetivo del presente estudio fue reutilizar el L-mentol, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-34627","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;\u00bfReutilizando el L-mentol para la medicina de sistemas y la terap\u00e9utica del c\u00e1ncer? El L-mentol induce apoptosis a trav\u00e9s de la caspasa 10 y al suprimir HSP90&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=34627\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;\u00bfReutilizando el L-mentol para la medicina de sistemas y la terap\u00e9utica del c\u00e1ncer? El L-mentol induce apoptosis a trav\u00e9s de la caspasa 10 y al suprimir HSP90&quot; -\" \/>\n<meta property=\"og:description\" content=\"Faridi, U., Dhawan, S. S., Pal, S., Gupta, S., Shukla, A. K., Darokar, M. P., &#8230; &amp; Shasany, A. K. (2016). Repurposing L-Menthol for Systems Medicine and Cancer Therapeutics? L-Menthol Induces Apoptosis through Caspase 10 and by Suppressing HSP90.\u00a0Omics: a journal of integrative biology, 20(1), 53-64. El objetivo del presente estudio fue reutilizar el L-mentol, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=34627\" \/>\n<meta property=\"article:published_time\" content=\"2019-12-16T05:30:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-sS64r_H5VJE\/XfP2EpkAIqI\/AAAAAAAAZLk\/1lQ3k5G4jJ456Ikl3IXRJ5iVsBkO5We_ACLcBGAsYHQ\/s1600\/omics.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=34627#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=34627\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00ab\u00bfReutilizando el L-mentol para la medicina de sistemas y la terap\u00e9utica del c\u00e1ncer? 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