{"id":34781,"date":"2019-12-20T03:30:23","date_gmt":"2019-12-20T02:30:23","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=34781"},"modified":"2019-12-20T03:30:23","modified_gmt":"2019-12-20T02:30:23","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-apoptosis-inducida-por-crisina-esta-mediada-por-la-activacion-de-caspasa-y-la-inactivacion-de-akt-en-celulas-de-leucemia-u93","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=34781","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa apoptosis inducida por crisina est\u00e1 mediada por la activaci\u00f3n de caspasa y la inactivaci\u00f3n de Akt en c\u00e9lulas de leucemia U937\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-rDWF8UjliTk\/XfaXWi2iY_I\/AAAAAAAAZRM\/4XFbK4mZ1BUeiNTa9-YUo17vuZEqxK9lACLcBGAsYHQ\/s1600\/Biochemical_Biophysical_Research_Comunication.gif\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-rDWF8UjliTk\/XfaXWi2iY_I\/AAAAAAAAZRM\/4XFbK4mZ1BUeiNTa9-YUo17vuZEqxK9lACLcBGAsYHQ\/s1600\/Biochemical_Biophysical_Research_Comunication.gif\" border=\"0\" data-original-width=\"220\" data-original-height=\"295\" \/><\/a>Woo, K. J., Jeong, Y. J., Park, J. W., &amp; Kwon, T. K. (2004).\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006291X04022405\">Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells<\/a>.\u00a0<i>Biochemical and Biophysical Research Communications,<\/i>\u00a0325(4), 1215-1222.<\/p>\n<p>La crisina es un compuesto natural biol\u00f3gicamente activo extra\u00eddo de muchas plantas, miel y prop\u00f3leos . Posee potentes propiedades antiinflamatorias, anticancer\u00edgenas y antioxidantes. El mecanismo por el cual la crisina inicia la apoptosis sigue siendo poco conocido.\u00a0<\/p>\n<p>En el presente informe, investigamos el efecto de la crisina en la v\u00eda apopt\u00f3tica en las c\u00e9lulas promonoc\u00edticas humanas U937.\u00a0<\/p>\n<p>Mostramos que la crisina induce la apoptosis en asociaci\u00f3n con la activaci\u00f3n de la caspasa 3 y que la v\u00eda de se\u00f1al de Akt juega un papel crucial en la apoptosis inducida por la crisina en las c\u00e9lulas U937. Adem\u00e1s, hemos demostrado que la inhibici\u00f3n de la fosforilaci\u00f3n de Akt en c\u00e9lulas U937 por el inhibidor espec\u00edfico de PI3K, LY294002significativamente, apoptosis mejorada. La sobreexpresi\u00f3n de un Akt constitutivamente activo (myr-Akt) en las c\u00e9lulas U937 inhibi\u00f3 la inducci\u00f3n de apoptosis, la activaci\u00f3n de la caspasa 3 y la escisi\u00f3n de PLC-\u03b31 por la crisina.\u00a0<\/p>\n<p>Juntos, estos hallazgos sugieren que la v\u00eda Akt juega un papel importante en la regulaci\u00f3n de la respuesta apopt\u00f3tica de las c\u00e9lulas de leucemia humana a la crisina y aumenta la posibilidad de que la interrupci\u00f3n combinada de la crisina y las v\u00edas relacionadas con PI3K \/ Akt puedan representar una estrategia terap\u00e9utica novedosa en tumores malignos hematol\u00f3gicos.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Woo, K. J., Jeong, Y. J., Park, J. W., &amp; Kwon, T. K. (2004).\u00a0Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells.\u00a0Biochemical and Biophysical Research Communications,\u00a0325(4), 1215-1222. La crisina es un compuesto natural biol\u00f3gicamente activo extra\u00eddo de muchas plantas, miel y prop\u00f3leos . Posee potentes propiedades antiinflamatorias, anticancer\u00edgenas y antioxidantes. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-34781","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La apoptosis inducida por crisina est\u00e1 mediada por la activaci\u00f3n de caspasa y la inactivaci\u00f3n de Akt en c\u00e9lulas de leucemia U937&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=34781\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La apoptosis inducida por crisina est\u00e1 mediada por la activaci\u00f3n de caspasa y la inactivaci\u00f3n de Akt en c\u00e9lulas de leucemia U937&quot; -\" \/>\n<meta property=\"og:description\" content=\"Woo, K. J., Jeong, Y. J., Park, J. W., &amp; Kwon, T. K. (2004).\u00a0Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells.\u00a0Biochemical and Biophysical Research Communications,\u00a0325(4), 1215-1222. La crisina es un compuesto natural biol\u00f3gicamente activo extra\u00eddo de muchas plantas, miel y prop\u00f3leos . Posee potentes propiedades antiinflamatorias, anticancer\u00edgenas y antioxidantes. [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=34781\" \/>\n<meta property=\"article:published_time\" content=\"2019-12-20T02:30:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-rDWF8UjliTk\/XfaXWi2iY_I\/AAAAAAAAZRM\/4XFbK4mZ1BUeiNTa9-YUo17vuZEqxK9lACLcBGAsYHQ\/s1600\/Biochemical_Biophysical_Research_Comunication.gif\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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