{"id":34784,"date":"2019-12-20T04:30:17","date_gmt":"2019-12-20T03:30:17","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=34784"},"modified":"2019-12-20T04:30:17","modified_gmt":"2019-12-20T03:30:17","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-modulacion-de-la-actividad-de-enzimas-proinflamatorias-cox-2-e-inos-por-derivados-de-crisina","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=34784","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abModulaci\u00f3n de la actividad de enzimas proinflamatorias, COX-2 e iNOS, por derivados de crisina\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-xnG8GpLfjEY\/XfaYgYhBD5I\/AAAAAAAAZRU\/DYOZAdmhAwYxztAW_sfJ969EvCh30RWwgCLcBGAsYHQ\/s1600\/Pharmacological_Research.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-xnG8GpLfjEY\/XfaYgYhBD5I\/AAAAAAAAZRU\/DYOZAdmhAwYxztAW_sfJ969EvCh30RWwgCLcBGAsYHQ\/s1600\/Pharmacological_Research.jpg\" border=\"0\" data-original-width=\"198\" data-original-height=\"264\" \/><\/a>Cho, H., Yun, C. W., Park, W. K., Kong, J. Y., Kim, K. S., Park, Y., &#8230; &amp; Kim, B. K. (2004).\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1043661803002482\">Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives<\/a>.\u00a0<i>Pharmacological Research<\/i>, 49(1), 37-43.<\/p>\n<p>La crisina , un compuesto de flavona natural que se encuentra en las plantas, tiene actividad antiinflamatoria que se ha explicado previamente en parte por la supresi\u00f3n de las actividades promotoras de enzimas proinflamatorias, ciclooxigenasa-2 (COX-2) y \u00f3xido n\u00edtrico sintasa inducible (iNOS).\u00a0<\/p>\n<p>Aqu\u00ed presentamos evidencia de que varios derivados de la crisina modulan las actividades, as\u00ed como la expresi\u00f3n, de las enzimas COX-2 e iNOS.\u00a0<\/p>\n<p>La producci\u00f3n de nitrato desencadenada por lipopolisac\u00e1rido (LPS) fue suprimida por el tratamiento de Raw cultivado264.7 c\u00e9lulas (macr\u00f3fagos \/ monocitos de ratones) con crisina, 5-hidroxi-7-metoxiflavona (Ch-2) y 5,7-diacetilflavona (Ch-4). Curiosamente, la enzima COX-2 fue fuertemente inhibida por Ch-4 (IC 50 = 2.7 \u03bcM) pero no por otros derivados. Adem\u00e1s, la inhibici\u00f3n de la enzima COX por Ch-4 fue selectiva para COX-2 sobre COX-1.\u00a0<\/p>\n<p>El modelado tridimensional mostr\u00f3 que Ch-4 encaja bien en el bolsillo de encuadernaci\u00f3n de COX-2. El modelo sugiri\u00f3 que existe un enlace de hidr\u00f3geno entre el ox\u00edgeno del grupo cetona en la posici\u00f3n 7 de Ch-4 y el grupo hidroxilo de Tyr355. El acoplamiento de Ch-4 en el mutante V523I de COX-2 indic\u00f3 que Ile523 de COX-1 podr\u00eda contribuir a la selectividad de COX-2 sobre COX-1. Ch-4 no mostr\u00f3 ning\u00fan efecto sobre la actividad de iNOS. La crisina y el Ch-2 inhibieron d\u00e9bilmente la actividad de la enzima iNOS en el ensayo de hemoglobina, pero no se conocen los mecanismos subyacentes de inhibici\u00f3n de iNOS por la crisina.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cho, H., Yun, C. W., Park, W. K., Kong, J. Y., Kim, K. S., Park, Y., &#8230; &amp; Kim, B. K. (2004).\u00a0Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives.\u00a0Pharmacological Research, 49(1), 37-43. La crisina , un compuesto de flavona natural que se encuentra en las plantas, tiene actividad antiinflamatoria que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-34784","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Modulaci\u00f3n de la actividad de enzimas proinflamatorias, COX-2 e iNOS, por derivados de crisina&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=34784\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Modulaci\u00f3n de la actividad de enzimas proinflamatorias, COX-2 e iNOS, por derivados de crisina&quot; -\" \/>\n<meta property=\"og:description\" content=\"Cho, H., Yun, C. W., Park, W. K., Kong, J. Y., Kim, K. S., Park, Y., &#8230; &amp; Kim, B. K. (2004).\u00a0Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives.\u00a0Pharmacological Research, 49(1), 37-43. La crisina , un compuesto de flavona natural que se encuentra en las plantas, tiene actividad antiinflamatoria que [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=34784\" \/>\n<meta property=\"article:published_time\" content=\"2019-12-20T03:30:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-xnG8GpLfjEY\/XfaYgYhBD5I\/AAAAAAAAZRU\/DYOZAdmhAwYxztAW_sfJ969EvCh30RWwgCLcBGAsYHQ\/s1600\/Pharmacological_Research.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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