{"id":34793,"date":"2019-12-21T00:30:35","date_gmt":"2019-12-20T23:30:35","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=34793"},"modified":"2019-12-21T00:30:35","modified_gmt":"2019-12-20T23:30:35","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-relacion-estructura-actividad-inhibidora-del-proteasoma-de-los-flavonoides-de-la-dieta-en-celulas-cancerosas-humanas","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=34793","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abRelaci\u00f3n estructura-actividad inhibidora del proteasoma de los flavonoides de la dieta en c\u00e9lulas cancerosas humanas\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-7V7jDZIR7tk\/XfacGNxtkvI\/AAAAAAAAZRs\/uR8RZgBBUjoDt_quKj0OmrbYCNc4qpF-gCLcBGAsYHQ\/s1600\/Frontiers_Biocience.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-7V7jDZIR7tk\/XfacGNxtkvI\/AAAAAAAAZRs\/uR8RZgBBUjoDt_quKj0OmrbYCNc4qpF-gCLcBGAsYHQ\/s1600\/Frontiers_Biocience.jpg\" border=\"0\" data-original-width=\"204\" data-original-height=\"248\" \/><\/a>Chen, D., Chen, M. S., Cui, Q. C., Yang, H., &amp; Dou, Q. P. (2007).\u00a0<a href=\"https:\/\/www.researchgate.net\/profile\/Huanjie_Yang\/publication\/6671666_Structure-proteasome-inhibitory_activity_relationships_of_dietary_flavonoids_in_human_cancer_cells\/links\/570c44cd08ae8883a1ffe98c\/Structure-proteasome-inhibitory-activity-relationships-of-dietary-flavonoids-in-human-cancer-cells.pdf\">Structure-proteasome-inhibitory activity relationships of dietary flavonoids in human cancer cells.<\/a>\u00a0<i>Front Biosci<\/i>, 12(1), 1935-45.<\/p>\n<p>La dieta rica en verduras y frutas se ha asociado con un riesgo reducido de c\u00e1ncer. Sin embargo, los mecanismos involucrados son desconocidos. Anteriormente, informamos que la apigenina flavonoide de la dieta podr\u00eda inhibir la actividad del proteasoma e inducir apoptosis en las c\u00e9lulas tumorales.\u00a0<\/p>\n<p>Para investigar m\u00e1s a fondo las relaciones estructura-actividad inhibidora del proteasoma, elegimos y probamos cinco flavonoides en la dieta, que incluyen luteolina, apigenina, crisina, naringenina y eriodictyol.\u00a0<\/p>\n<p>Encontramos que el orden de potencias inhibitorias y potencias inductoras de apoptosis de estos cinco compuestos en el proteasoma 20S purificado y las c\u00e9lulas tumorales era: (1) luteolina&gt; apigenina&gt; crisina, y (2) apigenina &gt;&gt; naringenina y luteolina &gt;&gt; eriodictyol. Por lo tanto, Los flavonoides con anillo B hidroxilado y \/ o anillo C insaturado son inhibidores de proteasoma potentes naturales e inductores de apoptosis de c\u00e9lulas tumorales. Adem\u00e1s, ni la apigenina ni la luteolina podr\u00edan inhibir el proteasoma e inducir apoptosis en c\u00e9lulas asesinas naturales humanas no transformadas.\u00a0<\/p>\n<p>Este hallazgo puede proporcionar una base molecular para los efectos preventivos del c\u00e1ncer observados cl\u00ednicamente de frutas y verduras.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chen, D., Chen, M. S., Cui, Q. C., Yang, H., &amp; Dou, Q. P. (2007).\u00a0Structure-proteasome-inhibitory activity relationships of dietary flavonoids in human cancer cells.\u00a0Front Biosci, 12(1), 1935-45. La dieta rica en verduras y frutas se ha asociado con un riesgo reducido de c\u00e1ncer. Sin embargo, los mecanismos involucrados son desconocidos. Anteriormente, informamos que la apigenina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-34793","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Relaci\u00f3n estructura-actividad inhibidora del proteasoma de los flavonoides de la dieta en c\u00e9lulas cancerosas humanas&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=34793\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Relaci\u00f3n estructura-actividad inhibidora del proteasoma de los flavonoides de la dieta en c\u00e9lulas cancerosas humanas&quot; -\" \/>\n<meta property=\"og:description\" content=\"Chen, D., Chen, M. S., Cui, Q. C., Yang, H., &amp; Dou, Q. P. (2007).\u00a0Structure-proteasome-inhibitory activity relationships of dietary flavonoids in human cancer cells.\u00a0Front Biosci, 12(1), 1935-45. La dieta rica en verduras y frutas se ha asociado con un riesgo reducido de c\u00e1ncer. Sin embargo, los mecanismos involucrados son desconocidos. Anteriormente, informamos que la apigenina [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=34793\" \/>\n<meta property=\"article:published_time\" content=\"2019-12-20T23:30:35+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-7V7jDZIR7tk\/XfacGNxtkvI\/AAAAAAAAZRs\/uR8RZgBBUjoDt_quKj0OmrbYCNc4qpF-gCLcBGAsYHQ\/s1600\/Frontiers_Biocience.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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