{"id":35753,"date":"2020-01-10T01:30:17","date_gmt":"2020-01-10T00:30:17","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=35753"},"modified":"2020-01-10T01:30:17","modified_gmt":"2020-01-10T00:30:17","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-el-alfa-bisabolol-un-compuesto-natural-no-toxico-induce-fuertemente-la-apoptosis-en-las-celulas-de-glioma","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=35753","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl alfa-bisabolol, un compuesto natural no t\u00f3xico, induce fuertemente la apoptosis en las c\u00e9lulas de glioma\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-0oLUDB3z36w\/XhhwYYK35hI\/AAAAAAAAZzI\/AkMIMtDJGxEWjVN-evCdshmv_C-FXFDCACLcBGAsYHQ\/s1600\/Biochemical_Biophysical_Research_Comunication.gif\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-0oLUDB3z36w\/XhhwYYK35hI\/AAAAAAAAZzI\/AkMIMtDJGxEWjVN-evCdshmv_C-FXFDCACLcBGAsYHQ\/s1600\/Biochemical_Biophysical_Research_Comunication.gif\" border=\"0\" data-original-width=\"220\" data-original-height=\"295\" \/><\/a>Cavalieri, E., Mariotto, S., Fabrizi, C., de Prati, A. C., Gottardo, R., Leone, S., &#8230; &amp; Suzuki, H. (2004).\u00a0<a href=\"https:\/\/s3.amazonaws.com\/academia.edu.documents\/45703950\/j.bbrc.2004.01.08820160517-873-fa5nwt.pdf?response-content-disposition=inline%3B%20filename%3D-Bisabolol_a_nontoxic_natural_compound.pdf&amp;X-Amz-Algorithm=AWS4-HMAC-SHA256&amp;X-Amz-Credential=AKIAIWOWYYGZ2Y53UL3A%2F20200110%2Fus-east-1%2Fs3%2Faws4_request&amp;X-Amz-Date=20200110T123415Z&amp;X-Amz-Expires=3600&amp;X-Amz-SignedHeaders=host&amp;X-Amz-Signature=5852ab8df67d5262ea0e88bae28ff218dfa81a28b4e4b1a52db17c673de19770\">\u03b1-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells<\/a>.\u00a0<i>Biochemical and biophysical research communications<\/i>, 315(3), 589-594.<\/p>\n<p>En este estudio, se descubri\u00f3 que el alfa-bisabolol, un alcohol sesquiterp\u00e9nico presente en el aceite esencial natural, tiene un fuerte efecto citot\u00f3xico dependiente del tiempo y la dosis en las c\u00e9lulas de glioma humano y de rata.\u00a0<\/p>\n<p>Despu\u00e9s de 24 h de tratamiento con 2.5-3.5 microM de alfa-bisabolol, la viabilidad de estas c\u00e9lulas se redujo en un 50% con respecto a las c\u00e9lulas no tratadas. Adem\u00e1s, la viabilidad de las c\u00e9lulas gliales de rata normales no se vio afectada por el tratamiento con alfa-bisabolol en las mismas concentraciones que anteriormente.\u00a0<\/p>\n<p>Las c\u00e9lulas de glioma tratadas con alta concentraci\u00f3n de alfa-bisabolol (10 microM) dieron como resultado una muerte celular del 100%. A juzgar por la acumulaci\u00f3n de hipo-G1, la escisi\u00f3n de la poli (ADP-ribosa) polimerasa y la formaci\u00f3n de escalera de ADN, la citotoxicidad desencadenada por el alfa-bisabolol result\u00f3 de la inducci\u00f3n de apoptosis. Adem\u00e1s, la disipaci\u00f3n del potencial transmembrana mitocondrial interno y la liberaci\u00f3n de citocromo c de la mitocondria indicaron que, en estas c\u00e9lulas de glioma, la apoptosis se produjo a trav\u00e9s de una v\u00eda intr\u00ednseca.\u00a0<\/p>\n<p>Como se se\u00f1al\u00f3 en los resultados experimentales, el alfa-bisabolol puede considerarse un nuevo compuesto capaz de inhibir el crecimiento y la supervivencia de las c\u00e9lulas de glioma.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cavalieri, E., Mariotto, S., Fabrizi, C., de Prati, A. C., Gottardo, R., Leone, S., &#8230; &amp; Suzuki, H. (2004).\u00a0\u03b1-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells.\u00a0Biochemical and biophysical research communications, 315(3), 589-594. En este estudio, se descubri\u00f3 que el alfa-bisabolol, un alcohol sesquiterp\u00e9nico presente en el aceite esencial natural, tiene un fuerte [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-35753","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El alfa-bisabolol, un compuesto natural no t\u00f3xico, induce fuertemente la apoptosis en las c\u00e9lulas de glioma&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=35753\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El alfa-bisabolol, un compuesto natural no t\u00f3xico, induce fuertemente la apoptosis en las c\u00e9lulas de glioma&quot; -\" \/>\n<meta property=\"og:description\" content=\"Cavalieri, E., Mariotto, S., Fabrizi, C., de Prati, A. C., Gottardo, R., Leone, S., &#8230; &amp; Suzuki, H. (2004).\u00a0\u03b1-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells.\u00a0Biochemical and biophysical research communications, 315(3), 589-594. En este estudio, se descubri\u00f3 que el alfa-bisabolol, un alcohol sesquiterp\u00e9nico presente en el aceite esencial natural, tiene un fuerte [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=35753\" \/>\n<meta property=\"article:published_time\" content=\"2020-01-10T00:30:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-0oLUDB3z36w\/XhhwYYK35hI\/AAAAAAAAZzI\/AkMIMtDJGxEWjVN-evCdshmv_C-FXFDCACLcBGAsYHQ\/s1600\/Biochemical_Biophysical_Research_Comunication.gif\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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