{"id":35965,"date":"2020-01-15T06:30:49","date_gmt":"2020-01-15T05:30:49","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=35965"},"modified":"2020-01-15T06:30:49","modified_gmt":"2020-01-15T05:30:49","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-andrografolida-inhibe-la-adhesion-de-las-celulas-de-cancer-gastrico-a-las-celulas-endoteliales-al-bloquear-la-expresion-de-e","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=35965","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa andrografolida inhibe la adhesi\u00f3n de las c\u00e9lulas de c\u00e1ncer g\u00e1strico a las c\u00e9lulas endoteliales al bloquear la expresi\u00f3n de E-selectina\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-vnpw5VEizXw\/Xh894vqAvLI\/AAAAAAAAZ7o\/u4qNmd5RdLYgn-GGpLCAMupszc3EaurSACLcBGAsYHQ\/s1600\/Anticancer_Research.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-vnpw5VEizXw\/Xh894vqAvLI\/AAAAAAAAZ7o\/u4qNmd5RdLYgn-GGpLCAMupszc3EaurSACLcBGAsYHQ\/s1600\/Anticancer_Research.jpg\" border=\"0\" data-original-width=\"192\" data-original-height=\"263\" \/><\/a>Jiang, C. G., Li, J. B., Liu, F. R., Wu, T., Yu, M., &amp; Xu, H. M. (2007).\u00a0<a href=\"http:\/\/ar.iiarjournals.org\/content\/27\/4B\/2439.full.pdf\">Andrographolide inhibits the adhesion of gastric cancer cells to endothelial cells by blocking E-selectin expression<\/a>.\u00a0<i>Anticancer Research<\/i>, 27(4B), 2439-2447.<\/p>\n<p>ANTECEDENTES: Recientemente se ha informado que la andrografolida, un componente activo aislado del herbario oficial chino Andrographis paniculata, tiene actividad anticancer\u00edgena. Sin embargo, el mecanismo molecular responsable de su acci\u00f3n anticancer\u00edgena no se ha definido completamente. En este estudio, investigamos el efecto de la andrograf\u00eda en la adhesi\u00f3n de las c\u00e9lulas de c\u00e1ncer g\u00e1strico a las c\u00e9lulas endoteliales activadas y la expresi\u00f3n de algunas mol\u00e9culas de adhesi\u00f3n celular.<\/p>\n<p>MATERIALES Y M\u00c9TODOS: Las c\u00e9lulas endoteliales humanas se preincubaron con andrograf\u00f3lido durante 6 hy luego se incubaron con el factor de necrosis tumoral de citocina durante 4 h. La expresi\u00f3n de la superficie endotelial de E-selectina se evalu\u00f3 mediante citometr\u00eda de flujo, inmunotinci\u00f3n y ELISA. Adem\u00e1s, investigamos la expresi\u00f3n de ARNm de E-selectina por RT-PCR. La expresi\u00f3n superficial de sialyl Lewis (X) de tres l\u00edneas celulares de c\u00e1ncer g\u00e1strico (SGC7901, MGC803, BGC823) y una l\u00ednea celular epitelial g\u00e1strica normal GES-1 se evalu\u00f3 mediante citometr\u00eda de flujo e inmunotinci\u00f3n. Luego se determin\u00f3 la adherencia de las c\u00e9lulas de c\u00e1ncer g\u00e1strico marcadas con CFSE y las c\u00e9lulas GES-1 a las monocapas de c\u00e9lulas endoteliales.<\/p>\n<p>RESULTADOS: La andrografolida redujo significativamente la expresi\u00f3n de E-selectina de las c\u00e9lulas endoteliales activadas e inhibi\u00f3 la expresi\u00f3n de E-selectina a nivel de ARNm. Tres l\u00edneas celulares de c\u00e1ncer g\u00e1strico expresaron altos niveles de sialil Lewis (X), mientras que GES-1 no. La andrografolida tambi\u00e9n disminuy\u00f3 significativamente la adherencia de las c\u00e9lulas de c\u00e1ncer g\u00e1strico a las c\u00e9lulas endoteliales estimuladas. La inhibici\u00f3n de la expresi\u00f3n de E-selectina correspondi\u00f3 a la reducci\u00f3n de la adherencia de las c\u00e9lulas tumorales. Los efectos de andrographolide sobre la adhesi\u00f3n tumoral fueron casi anulados por preincubaci\u00f3n con E-selectina y anticuerpo sialil Lewis (X).<\/p>\n<p>CONCLUSI\u00d3N: Estos hallazgos demuestran que la andrografolida suprime la adhesi\u00f3n de las c\u00e9lulas de c\u00e1ncer g\u00e1strico que expresan sialil Lewis (X) de alto nivel a las c\u00e9lulas endoteliales vasculares humanas al bloquear la expresi\u00f3n de E-selectina y, por lo tanto, puede representar un agente terap\u00e9utico candidato para el c\u00e1ncer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jiang, C. G., Li, J. B., Liu, F. R., Wu, T., Yu, M., &amp; Xu, H. M. (2007).\u00a0Andrographolide inhibits the adhesion of gastric cancer cells to endothelial cells by blocking E-selectin expression.\u00a0Anticancer Research, 27(4B), 2439-2447. ANTECEDENTES: Recientemente se ha informado que la andrografolida, un componente activo aislado del herbario oficial chino Andrographis paniculata, tiene actividad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-35965","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La andrografolida inhibe la adhesi\u00f3n de las c\u00e9lulas de c\u00e1ncer g\u00e1strico a las c\u00e9lulas endoteliales al bloquear la expresi\u00f3n de E-selectina&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=35965\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La andrografolida inhibe la adhesi\u00f3n de las c\u00e9lulas de c\u00e1ncer g\u00e1strico a las c\u00e9lulas endoteliales al bloquear la expresi\u00f3n de E-selectina&quot; -\" \/>\n<meta property=\"og:description\" content=\"Jiang, C. G., Li, J. B., Liu, F. R., Wu, T., Yu, M., &amp; Xu, H. M. (2007).\u00a0Andrographolide inhibits the adhesion of gastric cancer cells to endothelial cells by blocking E-selectin expression.\u00a0Anticancer Research, 27(4B), 2439-2447. 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G., Li, J. B., Liu, F. R., Wu, T., Yu, M., &amp; Xu, H. M. (2007).\u00a0Andrographolide inhibits the adhesion of gastric cancer cells to endothelial cells by blocking E-selectin expression.\u00a0Anticancer Research, 27(4B), 2439-2447. 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