{"id":36109,"date":"2020-01-18T03:30:07","date_gmt":"2020-01-18T02:30:07","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=36109"},"modified":"2020-01-18T03:30:07","modified_gmt":"2020-01-18T02:30:07","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-genisteina-inhibe-la-activacion-de-nf-kappa-b-en-celulas-de-cancer-de-prostata","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=36109","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa geniste\u00edna inhibe la activaci\u00f3n de NF-kappa B en c\u00e9lulas de c\u00e1ncer de pr\u00f3stata\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-R413aC7zSX4\/XiMsaYxXKUI\/AAAAAAAAaAU\/t-VHUsqLWBAkj8VUXrUhJf2sD3WDVafhgCLcBGAsYHQ\/s1600\/Nutrition_Cancer.png\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-R413aC7zSX4\/XiMsaYxXKUI\/AAAAAAAAaAU\/t-VHUsqLWBAkj8VUXrUhJf2sD3WDVafhgCLcBGAsYHQ\/s1600\/Nutrition_Cancer.png\" border=\"0\" data-original-width=\"200\" data-original-height=\"280\" \/><\/a>Davis, J. N., Kucuk, O., &amp; Sarkar, F. H. (1999).\u00a0<a href=\"https:\/\/www.researchgate.net\/profile\/Omer_Kucuk2\/publication\/12622751_Genistein_Inhibits_NF-kB_Activation_in_Prostate_Cancer_Cells\/links\/00b4953b7f4fcad76a000000\/Genistein-Inhibits-NF-kB-Activation-in-Prostate-Cancer-Cells.pdf\">Genistein inhibits NF-kB activation in prostate cancer cells<\/a>.\u00a0<i>Nutrition and cancer<\/i>, 35(2), 167-174.<\/p>\n<p>CONTEXTO: El c\u00e1ncer de pr\u00f3stata es la segunda causa principal de muertes relacionadas con el c\u00e1ncer en hombres en los Estados Unidos. Los estudios epidemiol\u00f3gicos indican que la susceptibilidad al c\u00e1ncer de pr\u00f3stata puede deberse en parte a las influencias ambientales, especialmente a la dieta. Se ha demostrado una asociaci\u00f3n entre la disminuci\u00f3n del riesgo de c\u00e1ncer de pr\u00f3stata y la mortalidad con un mayor consumo de productos de soja, lo que resulta en un aumento de los niveles de isoflavonas.\u00a0<\/p>\n<p>OBJETIVO: Anteriormente demostramos que la geniste\u00edna de isoflavona de soja inhibe el crecimiento celular e induce la apoptosis en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata. Para dilucidar a\u00fan m\u00e1s el mecanismo molecular por el cual la geniste\u00edna provoca su efecto apopt\u00f3tico, investigamos el papel de un factor de transcripci\u00f3n, factor nuclear-kappa B (NF-kappa B), en la l\u00ednea celular sensible a los andr\u00f3genos LNCaP y la l\u00ednea celular insensible a los andr\u00f3genos PC3.\u00a0<\/p>\n<p>RESULTADOS: Aqu\u00ed mostramos que la geniste\u00edna disminuye la uni\u00f3n al ADN de NF-kappa B y anula la activaci\u00f3n de NF-kappa B por agentes que da\u00f1an el ADN, H2O2 y factor de necrosis tumoral alfa, en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata independientemente de la sensibilidad a los andr\u00f3genos. Adem\u00e1s, hemos demostrado que la geniste\u00edna reduce la fosforilaci\u00f3n de la prote\u00edna inhibidora I kappa B alfa y bloquea la translocaci\u00f3n nuclear de NF-kappa B, prohibiendo la uni\u00f3n al ADN y evitando la activaci\u00f3n de NF-kappa B.\u00a0<\/p>\n<p>CONCLUSI\u00d3N: Estos resultados proporcionan un mecanismo por el cual la geniste\u00edna induce la apoptosis en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata: la inactivaci\u00f3n de NF-kappa B. Adem\u00e1s, la capacidad de la geniste\u00edna para derogar la activaci\u00f3n de NF-kappa B por agentes que da\u00f1an el ADN respalda firmemente el papel de la geniste\u00edna como agente quimiopreventivo. en c\u00e9lulas de c\u00e1ncer de pr\u00f3stata independientemente de la sensibilidad a los andr\u00f3genos.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Davis, J. N., Kucuk, O., &amp; Sarkar, F. H. (1999).\u00a0Genistein inhibits NF-kB activation in prostate cancer cells.\u00a0Nutrition and cancer, 35(2), 167-174. CONTEXTO: El c\u00e1ncer de pr\u00f3stata es la segunda causa principal de muertes relacionadas con el c\u00e1ncer en hombres en los Estados Unidos. Los estudios epidemiol\u00f3gicos indican que la susceptibilidad al c\u00e1ncer de pr\u00f3stata puede [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-36109","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La geniste\u00edna inhibe la activaci\u00f3n de NF-kappa B en c\u00e9lulas de c\u00e1ncer de pr\u00f3stata&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=36109\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La geniste\u00edna inhibe la activaci\u00f3n de NF-kappa B en c\u00e9lulas de c\u00e1ncer de pr\u00f3stata&quot; -\" \/>\n<meta property=\"og:description\" content=\"Davis, J. N., Kucuk, O., &amp; Sarkar, F. H. (1999).\u00a0Genistein inhibits NF-kB activation in prostate cancer cells.\u00a0Nutrition and cancer, 35(2), 167-174. CONTEXTO: El c\u00e1ncer de pr\u00f3stata es la segunda causa principal de muertes relacionadas con el c\u00e1ncer en hombres en los Estados Unidos. Los estudios epidemiol\u00f3gicos indican que la susceptibilidad al c\u00e1ncer de pr\u00f3stata puede [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=36109\" \/>\n<meta property=\"article:published_time\" content=\"2020-01-18T02:30:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-R413aC7zSX4\/XiMsaYxXKUI\/AAAAAAAAaAU\/t-VHUsqLWBAkj8VUXrUhJf2sD3WDVafhgCLcBGAsYHQ\/s1600\/Nutrition_Cancer.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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NF-kappa B en c\u00e9lulas de c\u00e1ncer de pr\u00f3stata\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=36109","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La geniste\u00edna inhibe la activaci\u00f3n de NF-kappa B en c\u00e9lulas de c\u00e1ncer de pr\u00f3stata\" -","og_description":"Davis, J. 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