{"id":36113,"date":"2020-01-18T04:30:34","date_gmt":"2020-01-18T03:30:34","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=36113"},"modified":"2020-01-18T04:30:34","modified_gmt":"2020-01-18T03:30:34","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-efecto-inhibitorio-de-la-silibinina-sobre-la-union-del-ligando-a-erbb1-y-la-senalizacion-mitogenica-asociada-el-crecimiento-y","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=36113","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEfecto inhibitorio de la silibinina sobre la uni\u00f3n del ligando a erbB1 y la se\u00f1alizaci\u00f3n mitog\u00e9nica asociada, el crecimiento y la s\u00edntesis de ADN en c\u00e9lulas avanzadas de carcinoma de pr\u00f3stata humano\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-YQBTWN1YN2I\/XiMuKIxR7_I\/AAAAAAAAaAc\/RXpxbUcSnjAbM3Z9R4Jrlkei0hnCBtWmQCLcBGAsYHQ\/s1600\/Molecular_Carcinogenesis.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-YQBTWN1YN2I\/XiMuKIxR7_I\/AAAAAAAAaAc\/RXpxbUcSnjAbM3Z9R4Jrlkei0hnCBtWmQCLcBGAsYHQ\/s1600\/Molecular_Carcinogenesis.jpg\" border=\"0\" data-original-width=\"100\" data-original-height=\"131\" \/><\/a>Sharma, Y., Agarwal, C., Singh, A. K., &amp; Agarwal, R. (2001).\u00a0<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/mc.1032\">Inhibitory effect of silibinin on ligand binding to erbB1 and associated mitogenic signaling, growth, and DNA synthesis in advanced human prostate carcinoma cells.<\/a>\u00a0<i>Molecular Carcinogenesis: Published in cooperation with the University of Texas MD Anderson Cancer Center<\/i>, 30(4), 224-236.<\/p>\n<p>FONDO: Recientemente mostramos el efecto inhibitorio de un antioxidante flavonoide, la silimarina, sobre la activaci\u00f3n de erbB1-Shc en c\u00e9lulas DU145 de c\u00e1ncer de pr\u00f3stata (PCA).\u00a0<\/p>\n<p>OBJETIVO: En el presente estudio, realizamos estudios de modelado mecanicista y molecular m\u00e1s detallados con silibinina pura para evaluar y definir su efecto sobre la se\u00f1alizaci\u00f3n de membrana relacionada con la activaci\u00f3n de erbB1 en c\u00e9lulas PCA LNCaP y DU145 humanas. Tambi\u00e9n se realizaron estudios para establecer las respuestas biol\u00f3gicas hacia la activaci\u00f3n de la prote\u00edna quinasa 1\/2 regulada por se\u00f1al extracelular (ERK1 \/ 2), el crecimiento celular y la s\u00edntesis de ADN.\u00a0<\/p>\n<p>M\u00c9TODO \/ RESULTADOS: Tratamiento de c\u00e9lulas sin suero de suero con varias dosis de silibinina durante 2 h seguido de 125, el factor de crecimiento epid\u00e9rmico I (EGF) mostr\u00f3 una inhibici\u00f3n de 30 a 75% en la uni\u00f3n de ligandos y una inhibici\u00f3n de 55 a 95% en su internalizaci\u00f3n en c\u00e9lulas LNCaP y una inhibici\u00f3n de 20 a 64% y 12 a 27% en estos dos eventos en c\u00e9lulas DU145. Los estudios de respuesta en el tiempo mostraron efectos similares. En estudios posteriores, el tratamiento de cultivos sin suero con silibinina seguido de EGF mostr\u00f3 fuertes efectos inhibitorios sobre las mol\u00e9culas de se\u00f1alizaci\u00f3n citoplasm\u00e1tica y de membrana. En el caso de la activaci\u00f3n de erbB1, la silibinina mostr\u00f3 una disminuci\u00f3n del 58-75% en LNCaP y una disminuci\u00f3n del 40-100% en las c\u00e9lulas DU145 a dosis de 50, 75 y 100 \u03bcg \/ ml.\u00a0<\/p>\n<p>Los efectos inhibitorios de la silibinina tambi\u00e9n fueron evidentes en la activaci\u00f3n de ERK1 \/ 2 (inhibici\u00f3n del 20\u201380%) en ambas l\u00edneas celulares. El tratamiento de cultivos sin suero con silibinina result\u00f3 en una inhibici\u00f3n del 20-40% y 30-55% del crecimiento de c\u00e9lulas LNCaP y DU145, respectivamente, a dosis similares despu\u00e9s de 1-3 d\u00edas de tratamiento, y 10 a 50% de muerte celular en ambas l\u00edneas celulares.\u00a0<\/p>\n<p>Bajo condiciones de suero al 10%, los tratamientos con silibinina id\u00e9nticos resultaron en una inhibici\u00f3n del 20-65% del crecimiento celular en las c\u00e9lulas LNCaP y DU145, pero no causaron ninguna muerte celular. Dosis similares de tratamientos con silibinina durante 24 h tambi\u00e9n dieron como resultado una inhibici\u00f3n del 25\u201360%, 35\u201340% y 36\u201350% de la s\u00edntesis de ADN cuando las c\u00e9lulas se cultivaron en suero al 10%, totalmente hambriento de suero y hambriento de suero m\u00e1s estimulado con EGF. , respectivamente.\u00a0<\/p>\n<p>La modelizaci\u00f3n molecular de la silibinina mostr\u00f3 que es un compuesto altamente lipof\u00edlico, lo que sugiere que interact\u00faa con la membrana plasm\u00e1tica rica en l\u00edpidos, incluida la uni\u00f3n con erbB1, compitiendo as\u00ed con la interacci\u00f3n EGF-erbB1. Debido a que el bucle autocrino ligando-erbB1 est\u00e1 implicado causalmente en la PCA avanzada e independiente de andr\u00f3genos,\u00a0<\/p>\n<p>CONCLUSI\u00d3N: Los efectos observados de la silibinina y su fuerte naturaleza lipof\u00edlica podr\u00edan ser \u00fatiles para desarrollar este agente para la prevenci\u00f3n y la terapia de la PCA<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sharma, Y., Agarwal, C., Singh, A. K., &amp; Agarwal, R. (2001).\u00a0Inhibitory effect of silibinin on ligand binding to erbB1 and associated mitogenic signaling, growth, and DNA synthesis in advanced human prostate carcinoma cells.\u00a0Molecular Carcinogenesis: Published in cooperation with the University of Texas MD Anderson Cancer Center, 30(4), 224-236. FONDO: Recientemente mostramos el efecto inhibitorio de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-36113","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Efecto inhibitorio de la silibinina sobre la uni\u00f3n del ligando a erbB1 y la se\u00f1alizaci\u00f3n mitog\u00e9nica asociada, el crecimiento y la s\u00edntesis de ADN en c\u00e9lulas avanzadas de carcinoma de pr\u00f3stata humano&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=36113\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Efecto inhibitorio de la silibinina sobre la uni\u00f3n del ligando a erbB1 y la se\u00f1alizaci\u00f3n mitog\u00e9nica asociada, el crecimiento y la s\u00edntesis de ADN en c\u00e9lulas avanzadas de carcinoma de pr\u00f3stata humano&quot; -\" \/>\n<meta property=\"og:description\" content=\"Sharma, Y., Agarwal, C., Singh, A. 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