{"id":36116,"date":"2020-01-18T05:30:53","date_gmt":"2020-01-18T04:30:53","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=36116"},"modified":"2020-01-18T05:30:53","modified_gmt":"2020-01-18T04:30:53","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-flavonoide-silibinina-inhibe-la-proliferacion-y-promueve-la-detencion-del-ciclo-celular-del-cancer-de-colon-humano","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=36116","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abFlavonoide, silibinina, inhibe la proliferaci\u00f3n y promueve la detenci\u00f3n del ciclo celular del c\u00e1ncer de colon humano\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-QD9Y2fNdMKY\/XiMv3-yM1cI\/AAAAAAAAaAk\/tFjkhPKeJFcTyqm9iogAdqvPt1gkVtvuQCLcBGAsYHQ\/s1600\/Journal_Surgical%2BResearch%252C.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-QD9Y2fNdMKY\/XiMv3-yM1cI\/AAAAAAAAaAk\/tFjkhPKeJFcTyqm9iogAdqvPt1gkVtvuQCLcBGAsYHQ\/s320\/Journal_Surgical%2BResearch%252C.jpg\" width=\"239\" height=\"320\" border=\"0\" data-original-width=\"574\" data-original-height=\"768\" \/><\/a>Hogan, F. S., Krishnegowda, N. K., Mikhailova, M., &amp; Kahlenberg, M. S. (2007).\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022480407002417\">Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer<\/a>.\u00a0<i>Journal of Surgical Research<\/i>, 143(1), 58-65.<\/p>\n<p>CONTEXTO: Se ha demostrado que los extractos antioxidantes de la planta de cardo mariano ( Silybum marianum ) tienen efectos antiproliferativos en varios tipos de tumores. La silibinina es el componente activo primario aislado del extracto crudo de semillas, la silimarina . Se ha utilizado como un suplemento diet\u00e9tico para la hepatoprotecci\u00f3n durante m\u00e1s de 2000 a\u00f1os. Se ha demostrado que la silibinina es segura en m\u00faltiples modelos animales y no ha tenido eventos adversos significativos en estudios en humanos.<\/p>\n<p>OBJETIVO: Investigamos el potencial de este flavolignano no t\u00f3xico para inhibir la proliferaci\u00f3n del c\u00e1ncer de colon humano .<\/p>\n<p>MATERIALES Y M\u00c9TODO: Se estudiaron tres l\u00edneas celulares bien caracterizadas, Fet, Geo y HCT116. El ensayo de viabilidad celular MTT se realiz\u00f3 para estudiar el efecto de la silibinina en la proliferaci\u00f3n. El an\u00e1lisis del clasificador celular activado por fluorescencia (FACS) se us\u00f3 para determinar los efectos de la silibinina en el ciclo celular y la apoptosis . La tinci\u00f3n con 4 &#8216;, 6\u2032-diamidina-2&#8217;-fenilindol (DAPI) con microscop\u00eda confocal se utiliz\u00f3 para confirmar morfol\u00f3gicamente estos resultados. Se midieron los niveles de escisi\u00f3n y expresi\u00f3n de poli ADP-ribosa polimerasa (PARP) de p21 , p27, ciclinas B1 \/ D1 y CDK-2. Ciclooxigenasa-2(COX-2) tambi\u00e9n se midieron los niveles. Los experimentos se realizaron por triplicado y se informaron como valores medios con errores est\u00e1ndar. Las medias se contrastaron usando an\u00e1lisis de varianza con la correcci\u00f3n de Dunnet para pruebas m\u00faltiples. Todas las pruebas estad\u00edsticas fueron de dos lados con un nivel de significaci\u00f3n del 5%.<\/p>\n<p>RESULTADOS: El ensayo MTT revel\u00f3 un fuerte efecto inhibidor dependiente de la dosis. El tratamiento con 75 \u03bcg \/ ml result\u00f3 en una inhibici\u00f3n del 50% de la viabilidad celular (IC-50) en las l\u00edneas Fet y Geo a las 72 h. Se obtuvo una dosis de CI50 de 40 ug \/ ml en HCT116, una l\u00ednea celular pobremente diferenciada, a las 72 h. El an\u00e1lisis FACS demostr\u00f3 una detenci\u00f3n del ciclo celular estad\u00edsticamente significativa en todas las l\u00edneas celulares. Se observaron detenciones de fase G 2 -M en l\u00edneas celulares Fet y Geo ( P &lt;0,001) y una detenci\u00f3n de G1 en HCT116 ( P = 0,005). Los aumentos triviales en las tasas apopt\u00f3ticas tempranas (2% a 3%) para Geo y HCT116 se observaron en el an\u00e1lisis FACS a trav\u00e9s del yoduro de anexina V-propidiot\u00e9cnica ( P &lt;0.05), pero no se observ\u00f3 evidencia de apoptosis en Western blot para escisi\u00f3n de PARP o DAPI . Los niveles de ciclina B1 \/ D1 y CDK-2 fueron inhibidos. Se observ\u00f3 una mayor expresi\u00f3n de inhibidores del ciclo celular, p21 o p27, y no hubo efecto sobre la expresi\u00f3n de COX-2.<\/p>\n<p>CONCLUSIONES: La silibinina inhibe significativamente la proliferaci\u00f3n mediante la detenci\u00f3n del ciclo celular mediante la inhibici\u00f3n de la actividad del promotor ciclina-CDK. A pesar de su perfil antioxidante, no hay efecto sobre la expresi\u00f3n de COX-2. La apoptosis no parece aumentar mucho en las l\u00edneas celulares de c\u00e1ncer de colon humano Fet, Geo y HCT116. M\u00e1s bien, la inhibici\u00f3n de las prote\u00ednas reguladoras del ciclo celular juega un papel fundamental en el mecanismo de acci\u00f3n de la silibinina, y esto puede servir como base para el uso combinado con quimioterap\u00e9uticos convencionales.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hogan, F. S., Krishnegowda, N. K., Mikhailova, M., &amp; Kahlenberg, M. S. (2007).\u00a0Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer.\u00a0Journal of Surgical Research, 143(1), 58-65. CONTEXTO: Se ha demostrado que los extractos antioxidantes de la planta de cardo mariano ( Silybum marianum ) tienen efectos antiproliferativos en varios tipos de tumores. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-36116","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Flavonoide, silibinina, inhibe la proliferaci\u00f3n y promueve la detenci\u00f3n del ciclo celular del c\u00e1ncer de colon humano&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=36116\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Flavonoide, silibinina, inhibe la proliferaci\u00f3n y promueve la detenci\u00f3n del ciclo celular del c\u00e1ncer de colon humano&quot; -\" \/>\n<meta property=\"og:description\" content=\"Hogan, F. S., Krishnegowda, N. K., Mikhailova, M., &amp; Kahlenberg, M. S. (2007).\u00a0Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer.\u00a0Journal of Surgical Research, 143(1), 58-65. CONTEXTO: Se ha demostrado que los extractos antioxidantes de la planta de cardo mariano ( Silybum marianum ) tienen efectos antiproliferativos en varios tipos de tumores. 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y promueve la detenci\u00f3n del ciclo celular del c\u00e1ncer de colon humano\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=36116","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"Flavonoide, silibinina, inhibe la proliferaci\u00f3n y promueve la detenci\u00f3n del ciclo celular del c\u00e1ncer de colon humano\" -","og_description":"Hogan, F. 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