{"id":36119,"date":"2020-01-18T06:30:35","date_gmt":"2020-01-18T05:30:35","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=36119"},"modified":"2020-01-18T06:30:35","modified_gmt":"2020-01-18T05:30:35","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-silibinina-regula-la-expresion-de-la-proteina-3-de-union-al-factor-de-crecimiento-insulinoide-e-inhibe-la-proliferacion-de-c","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=36119","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa silibinina regula la expresi\u00f3n de la prote\u00edna 3 de uni\u00f3n al factor de crecimiento insulinoide e inhibe la proliferaci\u00f3n de c\u00e9lulas de c\u00e1ncer de pr\u00f3stata independientes de andr\u00f3genos\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/--PvsBRkWRFM\/XiMxKQqHvfI\/AAAAAAAAaAs\/cph1bMHfoucKxdAWqCIwBOjZyjpVGGN4ACLcBGAsYHQ\/s1600\/Cancer_Research.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/--PvsBRkWRFM\/XiMxKQqHvfI\/AAAAAAAAaAs\/cph1bMHfoucKxdAWqCIwBOjZyjpVGGN4ACLcBGAsYHQ\/s1600\/Cancer_Research.jpg\" border=\"0\" data-original-width=\"240\" data-original-height=\"310\" \/><\/a>Zi, X., Zhang, J., Agarwal, R., &amp; Pollak, M. (2000).\u00a0<a href=\"https:\/\/cancerres.aacrjournals.org\/content\/canres\/60\/20\/5617.full.pdf\">Silibinin up-regulates insulin-like growth factor-binding protein 3 expression and inhibits proliferation of androgen-independent prostate cancer cells<\/a>.\u00a0<i>Cancer research<\/i>, 60(20), 5617-5620.<\/p>\n<p>FONDO: Recientemente se ha demostrado que la silibinina, un antioxidante flavonoide natural que se encuentra en el cardo mariano, tiene potentes efectos antiproliferativos contra diversas l\u00edneas celulares malignas, pero el mecanismo de acci\u00f3n subyacente a\u00fan no se ha dilucidado.\u00a0<\/p>\n<p>OBJETIVO: Investigamos el efecto de la silibinina en las c\u00e9lulas PC-3 de c\u00e1ncer de pr\u00f3stata independientes de andr\u00f3genos.\u00a0<\/p>\n<p>RESULTADOS: A concentraciones de silibinina farmacol\u00f3gicamente alcanzables (0.02-20 microM), observamos un aumento en la acumulaci\u00f3n de prote\u00edna de uni\u00f3n al factor de crecimiento similar a la insulina 3 (IGFBP-3) en medio acondicionado de c\u00e9lulas PC-3 y un aumento dependiente de la dosis de la abundancia de ARNm de IGFBP-3 con un aumento de 9 veces sobre la l\u00ednea de base a 20 microM de silibinina. Un oligodesoxinucle\u00f3tido antisentido IGFBP-3 que aten\u00faa la expresi\u00f3n g\u00e9nica de IGFBP-3 inducida por silibinina y la acumulaci\u00f3n de prote\u00ednas reduce la acci\u00f3n antiproliferativa de silibinina. Tambi\u00e9n observamos que la silibinina redujo la fosforilaci\u00f3n de la tirosina del sustrato 1 del receptor de insulina, lo que indica un efecto inhibitorio sobre la v\u00eda de se\u00f1alizaci\u00f3n mediada por el receptor del factor de crecimiento tipo insulina I.\u00a0<\/p>\n<p>CONCLUSI\u00d3N: Estos resultados sugieren un nuevo mecanismo por el cual la silibinina act\u00faa como un agente antiproliferativo y justifica el trabajo adicional para investigar el uso potencial de este compuesto o sus derivados en el tratamiento y prevenci\u00f3n del c\u00e1ncer de pr\u00f3stata.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zi, X., Zhang, J., Agarwal, R., &amp; Pollak, M. (2000).\u00a0Silibinin up-regulates insulin-like growth factor-binding protein 3 expression and inhibits proliferation of androgen-independent prostate cancer cells.\u00a0Cancer research, 60(20), 5617-5620. FONDO: Recientemente se ha demostrado que la silibinina, un antioxidante flavonoide natural que se encuentra en el cardo mariano, tiene potentes efectos antiproliferativos contra diversas l\u00edneas celulares [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-36119","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La silibinina regula la expresi\u00f3n de la prote\u00edna 3 de uni\u00f3n al factor de crecimiento insulinoide e inhibe la proliferaci\u00f3n de c\u00e9lulas de c\u00e1ncer de pr\u00f3stata independientes de andr\u00f3genos&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=36119\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La silibinina regula la expresi\u00f3n de la prote\u00edna 3 de uni\u00f3n al factor de crecimiento insulinoide e inhibe la proliferaci\u00f3n de c\u00e9lulas de c\u00e1ncer de pr\u00f3stata independientes de andr\u00f3genos&quot; -\" \/>\n<meta property=\"og:description\" content=\"Zi, X., Zhang, J., Agarwal, R., &amp; Pollak, M. (2000).\u00a0Silibinin up-regulates insulin-like growth factor-binding protein 3 expression and inhibits proliferation of androgen-independent prostate cancer cells.\u00a0Cancer research, 60(20), 5617-5620. FONDO: Recientemente se ha demostrado que la silibinina, un antioxidante flavonoide natural que se encuentra en el cardo mariano, tiene potentes efectos antiproliferativos contra diversas l\u00edneas celulares [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=36119\" \/>\n<meta property=\"article:published_time\" content=\"2020-01-18T05:30:35+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/--PvsBRkWRFM\/XiMxKQqHvfI\/AAAAAAAAaAs\/cph1bMHfoucKxdAWqCIwBOjZyjpVGGN4ACLcBGAsYHQ\/s1600\/Cancer_Research.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=36119#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=36119\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa silibinina regula la expresi\u00f3n de la prote\u00edna 3 de uni\u00f3n al factor de crecimiento insulinoide e inhibe la proliferaci\u00f3n de c\u00e9lulas de c\u00e1ncer de pr\u00f3stata independientes de andr\u00f3genos\u00bb\",\"datePublished\":\"2020-01-18T05:30:35+00:00\",\"dateModified\":\"2020-01-18T05:30:35+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=36119\"},\"wordCount\":326,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"articleSection\":[\"Sustancias Bioactivas\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=36119#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=36119\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?p=36119\",\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \\\"La silibinina regula la expresi\u00f3n de la prote\u00edna 3 de uni\u00f3n al factor de crecimiento insulinoide e inhibe la proliferaci\u00f3n de c\u00e9lulas de c\u00e1ncer de pr\u00f3stata independientes de andr\u00f3genos\\\" -\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\"},\"datePublished\":\"2020-01-18T05:30:35+00:00\",\"dateModified\":\"2020-01-18T05:30:35+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=36119#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=36119\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=36119#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/rina.naturopatiadigital.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa silibinina regula la expresi\u00f3n de la prote\u00edna 3 de uni\u00f3n al factor de crecimiento insulinoide e inhibe la proliferaci\u00f3n de c\u00e9lulas de c\u00e1ncer de pr\u00f3stata independientes de andr\u00f3genos\u00bb\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"name\":\"\",\"description\":\"Red Investigaci\u00f3n Naturop\u00e1tica\",\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\",\"name\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"contentUrl\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"width\":960,\"height\":960,\"caption\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\"},\"image\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/rina.naturopatiadigital.eu\"],\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La silibinina regula la expresi\u00f3n de la prote\u00edna 3 de uni\u00f3n al factor de crecimiento insulinoide e inhibe la proliferaci\u00f3n de c\u00e9lulas de c\u00e1ncer de pr\u00f3stata independientes de andr\u00f3genos\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=36119","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La silibinina regula la expresi\u00f3n de la prote\u00edna 3 de uni\u00f3n al factor de crecimiento insulinoide e inhibe la proliferaci\u00f3n de c\u00e9lulas de c\u00e1ncer de pr\u00f3stata independientes de andr\u00f3genos\" -","og_description":"Zi, X., Zhang, J., Agarwal, R., &amp; Pollak, M. (2000).\u00a0Silibinin up-regulates insulin-like growth factor-binding protein 3 expression and inhibits proliferation of androgen-independent prostate cancer cells.\u00a0Cancer research, 60(20), 5617-5620. FONDO: Recientemente se ha demostrado que la silibinina, un antioxidante flavonoide natural que se encuentra en el cardo mariano, tiene potentes efectos antiproliferativos contra diversas l\u00edneas celulares [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=36119","article_published_time":"2020-01-18T05:30:35+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/--PvsBRkWRFM\/XiMxKQqHvfI\/AAAAAAAAaAs\/cph1bMHfoucKxdAWqCIwBOjZyjpVGGN4ACLcBGAsYHQ\/s1600\/Cancer_Research.jpg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"1 minuto"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=36119#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=36119"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa silibinina regula la expresi\u00f3n de la prote\u00edna 3 de uni\u00f3n al factor de crecimiento insulinoide e inhibe la proliferaci\u00f3n de c\u00e9lulas de c\u00e1ncer de pr\u00f3stata independientes de andr\u00f3genos\u00bb","datePublished":"2020-01-18T05:30:35+00:00","dateModified":"2020-01-18T05:30:35+00:00","mainEntityOfPage":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=36119"},"wordCount":326,"commentCount":0,"publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"articleSection":["Sustancias Bioactivas"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rina.naturopatiadigital.eu\/?p=36119#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=36119","url":"https:\/\/rina.naturopatiadigital.eu\/?p=36119","name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La silibinina regula la expresi\u00f3n de la prote\u00edna 3 de uni\u00f3n al factor de crecimiento insulinoide e inhibe la proliferaci\u00f3n de c\u00e9lulas de c\u00e1ncer de pr\u00f3stata independientes de andr\u00f3genos\" -","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#website"},"datePublished":"2020-01-18T05:30:35+00:00","dateModified":"2020-01-18T05:30:35+00:00","breadcrumb":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=36119#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rina.naturopatiadigital.eu\/?p=36119"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=36119#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/rina.naturopatiadigital.eu\/"},{"@type":"ListItem","position":2,"name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa silibinina regula la expresi\u00f3n de la prote\u00edna 3 de uni\u00f3n al factor de crecimiento insulinoide e inhibe la proliferaci\u00f3n de c\u00e9lulas de c\u00e1ncer de pr\u00f3stata independientes de andr\u00f3genos\u00bb"}]},{"@type":"WebSite","@id":"https:\/\/rina.naturopatiadigital.eu\/#website","url":"https:\/\/rina.naturopatiadigital.eu\/","name":"","description":"Red Investigaci\u00f3n Naturop\u00e1tica","publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/rina.naturopatiadigital.eu\/#organization","name":"Organizaci\u00f3n Colegial Naturop\u00e1tica","url":"https:\/\/rina.naturopatiadigital.eu\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/","url":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","contentUrl":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","width":960,"height":960,"caption":"Organizaci\u00f3n Colegial Naturop\u00e1tica"},"image":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7","name":"admin","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/rina.naturopatiadigital.eu"],"url":"https:\/\/rina.naturopatiadigital.eu\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/36119","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=36119"}],"version-history":[{"count":0,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/36119\/revisions"}],"wp:attachment":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=36119"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=36119"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=36119"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}