{"id":36299,"date":"2020-01-22T01:00:21","date_gmt":"2020-01-22T00:00:21","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=36299"},"modified":"2020-01-22T01:00:21","modified_gmt":"2020-01-22T00:00:21","slug":"area-de-conocimiento-naturopatia-descriptiva-polimorfismos-en-genes-relacionados-con-el-estres-oxidativo-mpo-mnsod-cat-y-la-supervivencia-despues-del-tratamiento-para-el-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=36299","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abPolimorfismos en genes relacionados con el estr\u00e9s oxidativo (MPO, MnSOD, CAT) y la supervivencia despu\u00e9s del tratamiento para el c\u00e1ncer de mama\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-3pQ-25l802U\/Xihpq_moTGI\/AAAAAAAAaFE\/zZ48Hq_1Syod2k2eFeaAozHRrYqx2zAiQCLcBGAsYHQ\/s1600\/Cancer_Research.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-3pQ-25l802U\/Xihpq_moTGI\/AAAAAAAAaFE\/zZ48Hq_1Syod2k2eFeaAozHRrYqx2zAiQCLcBGAsYHQ\/s1600\/Cancer_Research.jpg\" border=\"0\" data-original-width=\"240\" data-original-height=\"310\" \/><\/a>Ambrosone, C. B., Ahn, J., Singh, K. K., Rezaishiraz, H., Furberg, H., Sweeney, C., &amp; Trovato, A. (2005).\u00a0<a href=\"http:\/\/cancerres.aacrjournals.org\/misc\/etoc-canres.xhtml?utm_source=alerts&amp;utm_medium=dropdown&amp;utm_campaign=menu\">Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer.\u00a0<\/a><i>Cancer research<\/i>,65(3), 1105-1111.\u00a0<\/p>\n<p>La causa inmediata de la muerte de las c\u00e9lulas cancerosas por la radioterapia y una serie de agentes terap\u00e9uticos es a trav\u00e9s de la generaci\u00f3n de especies reactivas de ox\u00edgeno, lo que resulta en da\u00f1os en el ADN y en la alteraci\u00f3n de la membrana mitocondrial, lo que desencadena la cascada apopt\u00f3tica.\u00a0<\/p>\n<p>Debido a que la super\u00f3xido dismutasa de manganeso mitocondrial cataliza la conversi\u00f3n de radicales super\u00f3xido en H (2) O (2), con la catalasa neutralizando H (2) O (2) y la mieloperoxidasa convirtiendo H (2) O (2) en \u00e1cido hipocloroso altamente reactivo, planteamos la hip\u00f3tesis que las variantes gen\u00e9ticas podr\u00edan afectar la eficacia del tratamiento para el c\u00e1ncer de mama y mejorar la supervivencia.\u00a0<\/p>\n<p>Se identificaron las mujeres que fueron tratadas con radiaci\u00f3n y \/ o quimioterapia por c\u00e1ncer de mama incidente en el Centro de Investigaci\u00f3n del C\u00e1ncer de Arkansas de 1985 a 1996. Se extrajo el ADN del tejido normal incluido en parafina (n = 279) y MnSOD, CAT, y los genotipos MPO se determinaron mediante espectrometr\u00eda de masas. Los modelos de riesgos proporcionales de Cox se ajustaron por edad, raza, etapa con estado de nodo y estado del receptor de estr\u00f3geno y receptor de progesterona.\u00a0<\/p>\n<p>Las mujeres que eran homocigotas para los alelos MPO G, asociadas con una mayor transcripci\u00f3n, tuvieron una mejor supervivencia (raz\u00f3n de riesgo, 0.60; intervalo de confianza del 95%, 0.38-0.95; P = 0.03) que aquellas con alelos comunes. Los genotipos CAT TT y MnSOD CC se asociaron con un riesgo reducido de muerte no significativo.\u00a0<\/p>\n<p>Cuando combinamos genotipos asociados con niveles m\u00e1s altos de especies reactivas de ox\u00edgeno para MnSOD y MPO, las mujeres con genotipos MnSOD CC y MPO GG tuvieron una disminuci\u00f3n de 3 veces en el riesgo de muerte (raz\u00f3n de riesgo, 0,33; intervalo de confianza del 95%, 0,13-0,80; P = 0,01).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ambrosone, C. B., Ahn, J., Singh, K. K., Rezaishiraz, H., Furberg, H., Sweeney, C., &amp; Trovato, A. (2005).\u00a0Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer.\u00a0Cancer research,65(3), 1105-1111.\u00a0 La causa inmediata de la muerte de las c\u00e9lulas cancerosas por la radioterapia y una serie de agentes terap\u00e9uticos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-36299","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Polimorfismos en genes relacionados con el estr\u00e9s oxidativo (MPO, MnSOD, CAT) y la supervivencia despu\u00e9s del tratamiento para el c\u00e1ncer de mama&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=36299\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Polimorfismos en genes relacionados con el estr\u00e9s oxidativo (MPO, MnSOD, CAT) y la supervivencia despu\u00e9s del tratamiento para el c\u00e1ncer de mama&quot; -\" \/>\n<meta property=\"og:description\" content=\"Ambrosone, C. B., Ahn, J., Singh, K. K., Rezaishiraz, H., Furberg, H., Sweeney, C., &amp; Trovato, A. (2005).\u00a0Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer.\u00a0Cancer research,65(3), 1105-1111.\u00a0 La causa inmediata de la muerte de las c\u00e9lulas cancerosas por la radioterapia y una serie de agentes terap\u00e9uticos [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=36299\" \/>\n<meta property=\"article:published_time\" content=\"2020-01-22T00:00:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-3pQ-25l802U\/Xihpq_moTGI\/AAAAAAAAaFE\/zZ48Hq_1Syod2k2eFeaAozHRrYqx2zAiQCLcBGAsYHQ\/s1600\/Cancer_Research.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" 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