{"id":36530,"date":"2020-01-28T01:30:36","date_gmt":"2020-01-28T00:30:36","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=36530"},"modified":"2020-01-28T01:30:36","modified_gmt":"2020-01-28T00:30:36","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-curcumina-alivia-la-radiculopatia-lumbar-al-reducir-la-neuroinflamacion-el-estres-oxidativo-y-los-factores-nociceptivos","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=36530","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina alivia la radiculopat\u00eda lumbar al reducir la neuroinflamaci\u00f3n, el estr\u00e9s oxidativo y los factores nociceptivos\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-VA4HixSXiY4\/Xi4PrXSH_0I\/AAAAAAAAaNc\/q1RmOC4DaM8aRh7LbEr1SGwlU8vwaciuQCLcBGAsYHQ\/s1600\/European_Cells-and-Materials.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-VA4HixSXiY4\/Xi4PrXSH_0I\/AAAAAAAAaNc\/q1RmOC4DaM8aRh7LbEr1SGwlU8vwaciuQCLcBGAsYHQ\/s320\/European_Cells-and-Materials.jpg\" width=\"243\" height=\"320\" border=\"0\" data-original-width=\"359\" data-original-height=\"471\" \/><\/a>Xiao, L., Ding, M., Fernandez, A., Zhao, P., Jin, L., &amp; Li, X. (2017). <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5521990\/\">Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors<\/a>.\u00a0<i>European cells &amp; materials<\/i>, 33, 279.<\/p>\n<p>CONTEXTO: Los tratamientos no quir\u00fargicos actuales para la radiculopat\u00eda lumbar [por ejemplo, esteroides epidurales y antagonistas del factor de necrosis tumoral \u03b1 (TNF-\u03b1)] no son efectivos ni seguros. Como producto natural no t\u00f3xico, la curcumina posee un perfil antiinflamatorio excepcional.\u00a0<\/p>\n<p>OBJETIVO: Presumimos que la curcumina alivia la radiculopat\u00eda lumbar al atenuar la neuroinflamaci\u00f3n, el estr\u00e9s oxidativo y los factores nociceptivos.\u00a0<\/p>\n<p>M\u00c9TODO \/ RESULTADOS: En un cultivo de ganglio de la ra\u00edz dorsal (DRG), la curcumina inhibi\u00f3 eficazmente la neuroinflamaci\u00f3n inducida por TNF-\u03b1, de una manera dependiente de la dosis, como se muestra por la expresi\u00f3n de ARNm y prote\u00edna de IL-6 y COX-2. Dichos efectos podr\u00edan estar mediados por la prote\u00edna quinasa B (AKT) y las v\u00edas de la quinasa regulada por se\u00f1al extracelular (ERK). Adem\u00e1s, se observ\u00f3 un efecto similar en la lucha contra la neuroinflamaci\u00f3n inducida por TNF-\u03b1 en neuronas primarias aisladas. Adicionalmente, la curcumina protegi\u00f3 a las neuronas de la producci\u00f3n excesiva de especies reactivas de ox\u00edgeno (ROS) desencadenadas por TNF-\u03b1 y la apoptosis celular y, en consecuencia, promovi\u00f3 la expresi\u00f3n de ARNm de las enzimas antioxidantes haem oxigenasa-1, catalasa y super\u00f3xido dismutasa-2.\u00a0<\/p>\n<p>Curiosamente, la prueba electr\u00f3nica de von Frey sugiri\u00f3 que la inyecci\u00f3n intraperitoneal de curcumina aboli\u00f3 significativamente la hiperalgesia ipsilateral secundaria a la hernia de disco en ratones, hasta 2 semanas despu\u00e9s de la cirug\u00eda. Tal alivio del dolor in vivo podr\u00eda atribuirse a la supresi\u00f3n, observada en el cultivo de explantes DRG, de neurop\u00e9ptidos provocados por TNF-\u03b1, tales como la sustancia P y el p\u00e9ptido relacionado con el gen de calcitonina.\u00a0<\/p>\n<p>Sorprendentemente, los datos de la tomograf\u00eda microcomputada (\u03bcCT) sugirieron que el tratamiento con curcumina podr\u00eda promover la recuperaci\u00f3n de la altura del disco despu\u00e9s de la hernia discal. La tinci\u00f3n con azul alcian \/ rojo picrosirio confirm\u00f3 que la administraci\u00f3n sist\u00e9mica de curcumina promovi\u00f3 la regeneraci\u00f3n de prote\u00ednas de la matriz extracelular, visualizadas por la presencia de abundante contenido de col\u00e1geno y proteoglicano reci\u00e9n formado en el disco herniado.\u00a0<\/p>\n<p>CONCLUSIONES: Nuestro estudio proporcion\u00f3 evidencia precl\u00ednica para acelerar este agente pleiotr\u00f3pico natural y no t\u00f3xico para convertirse en un tratamiento cl\u00ednico nuevo y seguro de la radiculopat\u00eda.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Xiao, L., Ding, M., Fernandez, A., Zhao, P., Jin, L., &amp; Li, X. (2017). Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors.\u00a0European cells &amp; materials, 33, 279. CONTEXTO: Los tratamientos no quir\u00fargicos actuales para la radiculopat\u00eda lumbar [por ejemplo, esteroides epidurales y antagonistas del factor de necrosis tumoral \u03b1 (TNF-\u03b1)] no [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-36530","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina alivia la radiculopat\u00eda lumbar al reducir la neuroinflamaci\u00f3n, el estr\u00e9s oxidativo y los factores nociceptivos&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=36530\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina alivia la radiculopat\u00eda lumbar al reducir la neuroinflamaci\u00f3n, el estr\u00e9s oxidativo y los factores nociceptivos&quot; -\" \/>\n<meta property=\"og:description\" content=\"Xiao, L., Ding, M., Fernandez, A., Zhao, P., Jin, L., &amp; Li, X. (2017). Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors.\u00a0European cells &amp; materials, 33, 279. CONTEXTO: Los tratamientos no quir\u00fargicos actuales para la radiculopat\u00eda lumbar [por ejemplo, esteroides epidurales y antagonistas del factor de necrosis tumoral \u03b1 (TNF-\u03b1)] no [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=36530\" \/>\n<meta property=\"article:published_time\" content=\"2020-01-28T00:30:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-VA4HixSXiY4\/Xi4PrXSH_0I\/AAAAAAAAaNc\/q1RmOC4DaM8aRh7LbEr1SGwlU8vwaciuQCLcBGAsYHQ\/s320\/European_Cells-and-Materials.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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CONTEXTO: Los tratamientos no quir\u00fargicos actuales para la radiculopat\u00eda lumbar [por ejemplo, esteroides epidurales y antagonistas del factor de necrosis tumoral \u03b1 (TNF-\u03b1)] no [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=36530","article_published_time":"2020-01-28T00:30:36+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/-VA4HixSXiY4\/Xi4PrXSH_0I\/AAAAAAAAaNc\/q1RmOC4DaM8aRh7LbEr1SGwlU8vwaciuQCLcBGAsYHQ\/s320\/European_Cells-and-Materials.jpg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=36530#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=36530"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: 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