{"id":36539,"date":"2020-01-28T03:30:47","date_gmt":"2020-01-28T02:30:47","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=36539"},"modified":"2020-01-28T03:30:47","modified_gmt":"2020-01-28T02:30:47","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-el-resveratrol-promueve-la-remielinizacion-en-el-modelo-de-cuprizona-de-la-esclerosis-multiple-estudio-bioquimico-e-histologic","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=36539","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl resveratrol promueve la remielinizaci\u00f3n en el modelo de cuprizona de la esclerosis m\u00faltiple: estudio bioqu\u00edmico e histol\u00f3gico\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-9WISVxaL-VU\/Xi7puD6Ip5I\/AAAAAAAAaN0\/omi9w90RL_A2_1Vte0005CH1CdWRVFZkwCLcBGAsYHQ\/s1600\/Molecular_Neurobiology.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-9WISVxaL-VU\/Xi7puD6Ip5I\/AAAAAAAAaN0\/omi9w90RL_A2_1Vte0005CH1CdWRVFZkwCLcBGAsYHQ\/s1600\/Molecular_Neurobiology.jpg\" border=\"0\" data-original-width=\"153\" data-original-height=\"203\" \/><\/a>Ghaiad, H. R., Nooh, M. M., El-Sawalhi, M. M., &amp; Shaheen, A. A. (2017).\u00a0<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s12035-016-9891-5\">Resveratrol promotes remyelination in cuprizone model of multiple sclerosis: biochemical and histological study<\/a>.\u00a0<i>Molecular neurobiology<\/i>, 54(5), 3219-3229.<\/p>\n<p>CONTEXTO: La esclerosis m\u00faltiple (EM) es una enfermedad neurodegenerativa desmielinizante, que representa una causa importante de discapacidad neurol\u00f3gica en adultos j\u00f3venes. El resveratrol es un polifenol estilbenoide, conocido por pasar la barrera hematoencef\u00e1lica y exhibir efectos antioxidantes, antiinflamatorios y neuroprotectores en varias lesiones cerebrales. El modelo de cuprizona de la EM es particularmente beneficioso en el estudio de la desmielinizaci\u00f3n \/ remielinizaci\u00f3n.\u00a0<\/p>\n<p>OBJETIVO: Nuestro estudio examin\u00f3 los posibles efectos neuroprotectores y pro-remielinizaci\u00f3n del resveratrol en ratones C57Bl \/ 6 intoxicados con cuprizona.\u00a0<\/p>\n<p>M\u00c9TODO Y MEDIDAS DE RESULTADOS: Los ratones fueron alimentados con comida que conten\u00eda 0,7% de cuprizona durante 7 d\u00edas, seguido de 3 semanas con una dieta de 0,2% de cuprizona. El resveratrol (250 mg \/ kg \/ d\u00eda, po) se administr\u00f3 durante 3 semanas a partir de la segunda semana. Al final del experimento, los animales se probaron en rotarod para evaluar los cambios en el equilibrio y la coordinaci\u00f3n motora. Luego se sacrificaron los ratones para medir el contenido cerebral de glutati\u00f3n, productos de peroxidaci\u00f3n lip\u00eddica, trifosfato de adenosina y subunidad fosfo-inhibidora del factor nuclear \u03baB-\u03b1. Tambi\u00e9n se evaluaron las actividades de la citocromo oxidasa y la super\u00f3xido dismutasa. Tambi\u00e9n se estim\u00f3 la expresi\u00f3n g\u00e9nica de la prote\u00edna b\u00e1sica de mielina, nucle\u00f3tido 2 &#8216;, 3\u2032-c\u00edclico 3&#8217; fosfodiesterasa, factor de transcripci\u00f3n de oligodendrocitos-1 (Olig1), subunidad NF-\u03baB p65 y factor de necrosis tumoral-\u03b1. Las secciones de cerebro te\u00f1idas con \u00e1cido azul \/ peri\u00f3dico Luxol fast-Schiff se puntuaron a ciegas para evaluar el estado de la mielina.\u00a0<\/p>\n<p>RESULTADOS: El resveratrol mejor\u00f3 efectivamente la coordinaci\u00f3n y el equilibrio motor, revirti\u00f3 la desmielinizaci\u00f3n inducida por la cuprizona, mejor\u00f3 la funci\u00f3n mitocondrial, alivi\u00f3 el estr\u00e9s oxidativo e inhibi\u00f3 la se\u00f1alizaci\u00f3n de NF-\u03baB. Interesantemente El resveratrol aument\u00f3 la expresi\u00f3n de Olig1 que se correlaciona positivamente con la remielinizaci\u00f3n activa.\u00a0<\/p>\n<p>CONCLUSIONES: El presente estudio puede ser el primero en indicar un efecto pro-remielinizante para el resveratrol que podr\u00eda representar un beneficio aditivo potencial en el tratamiento de la EM.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ghaiad, H. R., Nooh, M. M., El-Sawalhi, M. M., &amp; Shaheen, A. A. (2017).\u00a0Resveratrol promotes remyelination in cuprizone model of multiple sclerosis: biochemical and histological study.\u00a0Molecular neurobiology, 54(5), 3219-3229. CONTEXTO: La esclerosis m\u00faltiple (EM) es una enfermedad neurodegenerativa desmielinizante, que representa una causa importante de discapacidad neurol\u00f3gica en adultos j\u00f3venes. El resveratrol es un polifenol [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-36539","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El resveratrol promueve la remielinizaci\u00f3n en el modelo de cuprizona de la esclerosis m\u00faltiple: estudio bioqu\u00edmico e histol\u00f3gico&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=36539\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El resveratrol promueve la remielinizaci\u00f3n en el modelo de cuprizona de la esclerosis m\u00faltiple: estudio bioqu\u00edmico e histol\u00f3gico&quot; -\" \/>\n<meta property=\"og:description\" content=\"Ghaiad, H. R., Nooh, M. M., El-Sawalhi, M. M., &amp; Shaheen, A. A. (2017).\u00a0Resveratrol promotes remyelination in cuprizone model of multiple sclerosis: biochemical and histological study.\u00a0Molecular neurobiology, 54(5), 3219-3229. CONTEXTO: La esclerosis m\u00faltiple (EM) es una enfermedad neurodegenerativa desmielinizante, que representa una causa importante de discapacidad neurol\u00f3gica en adultos j\u00f3venes. El resveratrol es un polifenol [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=36539\" \/>\n<meta property=\"article:published_time\" content=\"2020-01-28T02:30:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-9WISVxaL-VU\/Xi7puD6Ip5I\/AAAAAAAAaN0\/omi9w90RL_A2_1Vte0005CH1CdWRVFZkwCLcBGAsYHQ\/s1600\/Molecular_Neurobiology.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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el modelo de cuprizona de la esclerosis m\u00faltiple: estudio bioqu\u00edmico e histol\u00f3gico\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=36539","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"El resveratrol promueve la remielinizaci\u00f3n en el modelo de cuprizona de la esclerosis m\u00faltiple: estudio bioqu\u00edmico e histol\u00f3gico\" -","og_description":"Ghaiad, H. 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