{"id":36542,"date":"2020-01-28T04:30:31","date_gmt":"2020-01-28T03:30:31","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=36542"},"modified":"2020-01-28T04:30:31","modified_gmt":"2020-01-28T03:30:31","slug":"36542","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=36542","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abNeuroprotecci\u00f3n de resveratrol en un modelo cr\u00f3nico de esclerosis m\u00faltiple en ratones\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-sS_TGcff8aU\/Xi7rj619saI\/AAAAAAAAaOE\/Vs99Mbli0m43tcqguom7UA7aC6hCq74mACLcBGAsYHQ\/s1600\/Frontiers_neurology.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-sS_TGcff8aU\/Xi7rj619saI\/AAAAAAAAaOE\/Vs99Mbli0m43tcqguom7UA7aC6hCq74mACLcBGAsYHQ\/s1600\/Frontiers_neurology.jpg\" border=\"0\" data-original-width=\"201\" data-original-height=\"259\" \/><\/a>Fonseca-Kelly, Z., Nassrallah, M., Uribe, J., Khan, R. S., Dine, K., Dutt, M., &amp; Shindler, K. S. (2012).\u00a0<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2012.00084\/full\">Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis<\/a>.\u00a0<i>Frontiers in neurology<\/i>, 3, 84.<\/p>\n<p>El resveratrol es un polifenol natural que activa SIRT1, una desacetilasa dependiente de NAD. SRT501, una formulaci\u00f3n farmac\u00e9utica de resveratrol con absorci\u00f3n sist\u00e9mica mejorada, previene la p\u00e9rdida neuronal sin suprimir la inflamaci\u00f3n en ratones con encefalomielitis autoinmune experimental recurrente (EAE), un modelo de esclerosis m\u00faltiple (EM). En contraste, se ha informado que el resveratrol suprime la inflamaci\u00f3n en EAE cr\u00f3nica, aunque no se evaluaron los efectos neuroprotectores.<\/p>\n<p>Los estudios actuales examinan los posibles efectos neuroprotectores e inmunomoduladores del resveratrol en EAE cr\u00f3nica inducida por inmunizaci\u00f3n con p\u00e9ptido de glucoprote\u00edna oligodendroglial de mielina en ratones C57 \/ Bl6. Se compararon los efectos de dos formulaciones distintas de resveratrol administradas diariamente por v\u00eda oral.<\/p>\n<p>El resveratrol retras\u00f3 la aparici\u00f3n de EAE en comparaci\u00f3n con los ratones EAE tratados con veh\u00edculo, pero no previno o alter\u00f3 el fenotipo de inflamaci\u00f3n en las m\u00e9dulas espinales o los nervios \u00f3pticos. Se observaron efectos neuroprotectores significativos, con un mayor n\u00famero de c\u00e9lulas ganglionares de la retina en los ojos de ratones EAE tratados con resveratrol con inflamaci\u00f3n del nervio \u00f3ptico. Los resultados demuestran que el resveratrol previene la p\u00e9rdida neuronal en este modelo de enfermedad desmielinizante cr\u00f3nica, similar a sus efectos en la EAE recurrente.<\/p>\n<p>Las diferencias en la inmunosupresi\u00f3n en comparaci\u00f3n con estudios previos sugieren que los efectos inmunomoduladores pueden ser limitados y pueden depender de par\u00e1metros de inmunizaci\u00f3n espec\u00edficos o del momento del tratamiento.<\/p>\n<p>Es importante destacar que los efectos neuroprotectores pueden ocurrir sin inmunosupresi\u00f3n, lo que sugiere un beneficio aditivo potencial del resveratrol en combinaci\u00f3n con terapias antiinflamatorias para la EM.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fonseca-Kelly, Z., Nassrallah, M., Uribe, J., Khan, R. S., Dine, K., Dutt, M., &amp; Shindler, K. S. (2012).\u00a0Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis.\u00a0Frontiers in neurology, 3, 84. El resveratrol es un polifenol natural que activa SIRT1, una desacetilasa dependiente de NAD. SRT501, una formulaci\u00f3n farmac\u00e9utica de resveratrol con absorci\u00f3n sist\u00e9mica mejorada, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-36542","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Neuroprotecci\u00f3n de resveratrol en un modelo cr\u00f3nico de esclerosis m\u00faltiple en ratones&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=36542\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Neuroprotecci\u00f3n de resveratrol en un modelo cr\u00f3nico de esclerosis m\u00faltiple en ratones&quot; -\" \/>\n<meta property=\"og:description\" content=\"Fonseca-Kelly, Z., Nassrallah, M., Uribe, J., Khan, R. S., Dine, K., Dutt, M., &amp; Shindler, K. S. (2012).\u00a0Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis.\u00a0Frontiers in neurology, 3, 84. El resveratrol es un polifenol natural que activa SIRT1, una desacetilasa dependiente de NAD. 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