{"id":37135,"date":"2020-02-13T00:30:11","date_gmt":"2020-02-12T23:30:11","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=37135"},"modified":"2020-02-13T00:30:11","modified_gmt":"2020-02-12T23:30:11","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-los-efectos-de-la-curcumina-en-el-receptor-de-quimiocina-cxcr4-en-lineas-celulares-de-melanoma-uveal-humano","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=37135","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLos efectos de la curcumina en el receptor de quimiocina CXCR4 en l\u00edneas celulares de melanoma uveal humano\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-pVW_s1Xu0lk\/XkP4XNN7NuI\/AAAAAAAAaoQ\/9SYYQcoSJ7MExv4iNwnBRJU4dqW8cPr4ACLcBGAsYHQ\/s1600\/Investigative_Ophthalmology%2B%2526%2BVisual%2BScience.gif\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-pVW_s1Xu0lk\/XkP4XNN7NuI\/AAAAAAAAaoQ\/9SYYQcoSJ7MExv4iNwnBRJU4dqW8cPr4ACLcBGAsYHQ\/s1600\/Investigative_Ophthalmology%2B%2526%2BVisual%2BScience.gif\" border=\"0\" data-original-width=\"175\" data-original-height=\"234\" \/><\/a>Tsoukas, P. A., Di Cesare, S., Logan, P., Faingold, D., Bakalian, S., &amp; Burnier Jr, M. N. (2009).\u00a0<a href=\"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2365785\">The Effects of Curcumin on the Chemokine Receptor CXCR4 in Human Uveal Melanoma Cell Lines<\/a>.\u00a0<i>Investigative Ophthalmology &amp; Visual Science<\/i>, 50(13), 3393-3393.<\/p>\n<p>PROP\u00d3SITO: : Estudios sobre una variedad de c\u00e1nceres han indicado que el CXC de quimiocinas receptor-4 (CXCR4) juega un papel importante en la celda proliferaci\u00f3n y met\u00e1stasis del c\u00e1ncer. Se ha demostrado que la curcumina, el componente principal de la c\u00farcuma de especias com\u00fan, es capaz de estimular la apoptosis, reducir la proliferaci\u00f3n celular e inhibir la met\u00e1stasis. Los datos anteriores mostraron que la curcumina redujo la proliferaci\u00f3n de l\u00edneas celulares de melanoma uveal (UM) y aument\u00f3 la expresi\u00f3n de NM23, un gen supresor de met\u00e1stasis . Para investigar m\u00e1s a fondo la relaci\u00f3n entre la curcumina y la UM, evaluamos su efecto sobre CXCR4 en l\u00edneas celulares de UM.<\/p>\n<p>M\u00c9TODO: l\u00edneas de c\u00e9lulas Cinco humano UM (92.1, MKT-BR, OCM-1, SP6.5 y UW-1) se ensayaron para determinar la concentraci\u00f3n no t\u00f3xica m\u00e1xima de la curcumina. Se encontr\u00f3 que la LD 50 apropiada era 50 \u00b5M usando un ensayo de proliferaci\u00f3n TOX-6. La expresi\u00f3n CXCR4 de las c\u00e9lulas UM tratadas con curcumina y las c\u00e9lulas UM no tratadas se determin\u00f3 por PCR cuantitativa en tiempo real. El qPCR se realiz\u00f3 utilizando el m\u00e9todo de PCR SYBR Green de un paso QuantiTect\u00ae . Se usaron secuencias de cebadores para determinar la expresi\u00f3n de CXCR4, y la expresi\u00f3n se normaliz\u00f3 luego con el gen de la ama de casa \u03b2-actina. Para verificar la expresi\u00f3n de CXCR4 a nivel de prote\u00edna, an\u00e1lisis de citometr\u00eda de flujo se realiz\u00f3 usando un anticuerpo monoclonal espec\u00edfico dirigido a CXCR4 que se marc\u00f3 con un fluorocromo apropiado. Tambi\u00e9n se incluyeron controles negativos para descartar auto-fluorescencia.<\/p>\n<p>RESULTADOS: Curcumina, a una dosis de 50 micras mat\u00f3 a la mitad de las c\u00e9lulas UM en las cinco l\u00edneas celulares. Todas las c\u00e9lulas supervivientes de las cinco l\u00edneas celulares UM demostraron un aumento sustancial en la expresi\u00f3n del gen CXCR4 cuando se trataron con curcumina. La expresi\u00f3n de ARNm regulada por aumento de CXCR4 vari\u00f3 de un aumento de 2,4 veces a 20 veces el nivel de expresi\u00f3n normal. El an\u00e1lisis de citometr\u00eda de flujo confirm\u00f3 este aumento en la expresi\u00f3n de la prote\u00edna CXCR4 de la superficie celular.<\/p>\n<p>CONCLUSIONES: La curcumina causa la muerte de c\u00e9lulas de melanoma uveal e inhibe celular proliferaci\u00f3n. Sin embargo, la curcumina tambi\u00e9n causa una regulaci\u00f3n positiva de CXCR4 o puede seleccionar c\u00e9lulas CXCR4 + UM en la fracci\u00f3n sobreviviente , despu\u00e9s del tratamiento. Actualmente se est\u00e1n realizando estudios futuros para determinar si los efectos inhibitorios de la curcumina en la proliferaci\u00f3n celular son m\u00e1s beneficiosos que los efectos adversos que se muestran con la regulaci\u00f3n positiva de CXCR4. Adem\u00e1s, el trabajo futuro tambi\u00e9n se centra en si la curcumina provoca la selecci\u00f3n o la regulaci\u00f3n positiva de las c\u00e9lulas CXCR4 + UM.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tsoukas, P. A., Di Cesare, S., Logan, P., Faingold, D., Bakalian, S., &amp; Burnier Jr, M. N. (2009).\u00a0The Effects of Curcumin on the Chemokine Receptor CXCR4 in Human Uveal Melanoma Cell Lines.\u00a0Investigative Ophthalmology &amp; Visual Science, 50(13), 3393-3393. PROP\u00d3SITO: : Estudios sobre una variedad de c\u00e1nceres han indicado que el CXC de quimiocinas receptor-4 (CXCR4) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-37135","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Los efectos de la curcumina en el receptor de quimiocina CXCR4 en l\u00edneas celulares de melanoma uveal humano&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=37135\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Los efectos de la curcumina en el receptor de quimiocina CXCR4 en l\u00edneas celulares de melanoma uveal humano&quot; -\" \/>\n<meta property=\"og:description\" content=\"Tsoukas, P. A., Di Cesare, S., Logan, P., Faingold, D., Bakalian, S., &amp; Burnier Jr, M. N. (2009).\u00a0The Effects of Curcumin on the Chemokine Receptor CXCR4 in Human Uveal Melanoma Cell Lines.\u00a0Investigative Ophthalmology &amp; Visual Science, 50(13), 3393-3393. 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