{"id":37137,"date":"2020-02-13T01:30:15","date_gmt":"2020-02-13T00:30:15","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=37137"},"modified":"2020-02-13T01:30:15","modified_gmt":"2020-02-13T00:30:15","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-berberina-atenua-la-reparacion-de-la-escision-de-la-base-mediada-por-xrcc1-y-sensibiliza-las-celulas-de-cancer-de-mama-a-los","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=37137","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa berberina aten\u00faa la reparaci\u00f3n de la escisi\u00f3n de la base mediada por XRCC1 y sensibiliza las c\u00e9lulas de c\u00e1ncer de mama a los f\u00e1rmacos quimioterap\u00e9uticos\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-nW6KeMm_8vM\/XkP7usHTXtI\/AAAAAAAAaoY\/8CqnteRwLMk0Q2RWwsK_L-Cp1x7MErQZwCLcBGAsYHQ\/s1600\/Journal_Cellular_Molecular_Medicine.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-nW6KeMm_8vM\/XkP7usHTXtI\/AAAAAAAAaoY\/8CqnteRwLMk0Q2RWwsK_L-Cp1x7MErQZwCLcBGAsYHQ\/s1600\/Journal_Cellular_Molecular_Medicine.jpg\" border=\"0\" data-original-width=\"99\" data-original-height=\"144\" \/><\/a>Gao, X., Wang, J., Li, M., Wang, J., Lv, J., Zhang, L., &#8230; &amp; Mao, W. (2019).<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14560\">\u00a0Berberine attenuates XRCC1\u2010mediated base excision repair and sensitizes breast cancer cells to the chemotherapeutic drugs<\/a>.\u00a0<i>Journal of cellular and molecular medicine<\/i>, 23(10), 6797-6804.<\/p>\n<p>La berberina (BBR) es un alcaloide isoquinolina natural, que se utiliza en la medicina tradicional por sus actividades antimicrobianas, antiprotozoarias y antidiarreicas. La berberina interact\u00faa con el ADN y muestra actividades anticancer\u00edgenas, pero sus efectos sobre la reparaci\u00f3n del ADN celular y los tratamientos sint\u00e9ticos con f\u00e1rmacos quimioterap\u00e9uticos siguen sin estar claros.\u00a0<\/p>\n<p>En este estudio, investigamos los efectos de BBR en la reparaci\u00f3n del ADN y en la sensibilizaci\u00f3n de las c\u00e9lulas de c\u00e1ncer de mama a diferentes tipos de medicamentos antitumorales que da\u00f1an el ADN.\u00a0<\/p>\n<p>Encontramos que BBR detuvo c\u00e9lulas en la fase S del ciclo celular e indujo roturas de ADN. El an\u00e1lisis de crecimiento celular mostr\u00f3 c\u00e9lulas MDA-MB-231 sensibilizadas con BBR a cisplatino, camptotecina y metanosulfonato de metilo; sin embargo, BBR no tuvo efectos sin\u00e9rgicos con hidroxurea y olaparib. Estos resultados sugieren que la BBR solo afecta las v\u00edas espec\u00edficas de reparaci\u00f3n del ADN. La transferencia Western mostr\u00f3 expresiones XRCC1 reguladas negativamente de BBR, y el XRCC1 rescatado recuper\u00f3 la resistencia de las c\u00e9lulas cancerosas a BBR.\u00a0<\/p>\n<p>Por lo tanto, concluimos que BBR interfiere con la reparaci\u00f3n de la escisi\u00f3n de la base mediada por XRCC1 para sensibilizar las c\u00e9lulas cancerosas a los f\u00e1rmacos quimioterap\u00e9uticos. Estos hallazgos pueden contribuir a comprender los efectos de BBR en la reparaci\u00f3n del ADN celular y el empleo cl\u00ednico de BBR en el tratamiento del c\u00e1ncer de mama.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gao, X., Wang, J., Li, M., Wang, J., Lv, J., Zhang, L., &#8230; &amp; Mao, W. (2019).\u00a0Berberine attenuates XRCC1\u2010mediated base excision repair and sensitizes breast cancer cells to the chemotherapeutic drugs.\u00a0Journal of cellular and molecular medicine, 23(10), 6797-6804. La berberina (BBR) es un alcaloide isoquinolina natural, que se utiliza en la medicina tradicional por sus [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-37137","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La berberina aten\u00faa la reparaci\u00f3n de la escisi\u00f3n de la base mediada por XRCC1 y sensibiliza las c\u00e9lulas de c\u00e1ncer de mama a los f\u00e1rmacos quimioterap\u00e9uticos&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=37137\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La berberina aten\u00faa la reparaci\u00f3n de la escisi\u00f3n de la base mediada por XRCC1 y sensibiliza las c\u00e9lulas de c\u00e1ncer de mama a los f\u00e1rmacos quimioterap\u00e9uticos&quot; -\" \/>\n<meta property=\"og:description\" content=\"Gao, X., Wang, J., Li, M., Wang, J., Lv, J., Zhang, L., &#8230; &amp; Mao, W. (2019).\u00a0Berberine attenuates XRCC1\u2010mediated base excision repair and sensitizes breast cancer cells to the chemotherapeutic drugs.\u00a0Journal of cellular and molecular medicine, 23(10), 6797-6804. La berberina (BBR) es un alcaloide isoquinolina natural, que se utiliza en la medicina tradicional por sus [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=37137\" \/>\n<meta property=\"article:published_time\" content=\"2020-02-13T00:30:15+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-nW6KeMm_8vM\/XkP7usHTXtI\/AAAAAAAAaoY\/8CqnteRwLMk0Q2RWwsK_L-Cp1x7MErQZwCLcBGAsYHQ\/s1600\/Journal_Cellular_Molecular_Medicine.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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(2019).\u00a0Berberine attenuates XRCC1\u2010mediated base excision repair and sensitizes breast cancer cells to the chemotherapeutic drugs.\u00a0Journal of cellular and molecular medicine, 23(10), 6797-6804. 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