{"id":37325,"date":"2020-02-20T01:30:58","date_gmt":"2020-02-20T00:30:58","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=37325"},"modified":"2020-02-20T01:30:58","modified_gmt":"2020-02-20T00:30:58","slug":"area-de-conocimiento-naturopatia-descriptiva-aumento-de-la-oxidacion-del-adn-nuclear-en-el-cerebro-en-la-enfermedad-de-alzheimer","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=37325","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abAumento de la oxidaci\u00f3n del ADN nuclear en el cerebro en la enfermedad de Alzheimer\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-uC36QfW9DcI\/Xkl2G3G4YfI\/AAAAAAAAaxA\/idLDU1rqMpAqH01KjdUy5QHaJPXbriroACLcBGAsYHQ\/s1600\/Journal_Neurochemistry.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-uC36QfW9DcI\/Xkl2G3G4YfI\/AAAAAAAAaxA\/idLDU1rqMpAqH01KjdUy5QHaJPXbriroACLcBGAsYHQ\/s320\/Journal_Neurochemistry.jpg\" width=\"243\" height=\"320\" border=\"0\" data-original-width=\"400\" data-original-height=\"526\" \/><\/a>Gabbita, S. P., Lovell, M. A., &amp; Markesbery, W. R. (1998).\u00a0<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1046\/j.1471-4159.1998.71052034.x\">Increased nuclear DNA oxidation in the brain in Alzheimer&#8217;s disease<\/a>.\u00a0<i>Journal of neurochemistry<\/i>, 71(5), 2034-2040.\u00a0<\/p>\n<p>FONDO: M\u00faltiples l\u00edneas de evidencia indican que el estr\u00e9s oxidativo contribuye a la muerte neuronal en la enfermedad de Alzheimer (EA). El da\u00f1o oxidativo que se produce en el ADN puede desempe\u00f1ar un papel tanto en el envejecimiento normal como en las enfermedades neurodegenerativas, incluida la EA.\u00a0<\/p>\n<p>OBJETIVO: Este es un estudio del da\u00f1o oxidativo que ocurre en el ADN nuclear en los cerebros de pacientes con EA y sujetos de control cognitivamente intactos, evaluados prospectivamente y de edad similar.\u00a0<\/p>\n<p>M\u00c9TODO: El ADN nuclear de los l\u00f3bulos frontal, temporal y parietal y el cerebelo se aisl\u00f3 de 11 sujetos de control y 9 sujetos con AD, y las bases de purina y pirimidina oxidadas se cuantificaron mediante cromatograf\u00eda de gases \/ espectrometr\u00eda de masas. Los an\u00e1logos de bases oxidadas marcadas con is\u00f3topos estables se utilizaron como patrones internos para medir 5-hidroxiuracilo, 5-hidroxicitosina, 8-hidroxiadenina, 4,6-diamino-5-formamidopirimidina (Fapy-adenina), 8-hidroxiguanina y 2,6-diamino-4-hidroxi-5-formamidopirimidina (Fapy-guanina).\u00a0<\/p>\n<p>RESULTADOS: Se encontraron elevaciones estad\u00edsticamente significativas de 5-hidroxicitosina, 5-hidroxiuracilo, 8-hidroxiadenina y 8-hidroxiguanina en el cerebro con AD en comparaci\u00f3n con los sujetos control (p &lt;0,05). Hubo una mayor tendencia en los niveles de Fapy-adenina en el cerebro con EA, y la Fapy-guanina mostr\u00f3 una tendencia hacia niveles m\u00e1s altos en los cerebros de control en comparaci\u00f3n con la EA. Un nivel generalmente mayor de da\u00f1o oxidativo del ADN estaba presente en las regiones neocorticales que el cerebelo. No se observ\u00f3 correlaci\u00f3n significativa entre las bases oxidadas y el enredo neurofibrilar y los recuentos de placa senil.\u00a0<\/p>\n<p>CONCLUSI\u00d3N: Nuestros resultados demuestran que el da\u00f1o al ADN nuclear por radicales derivados del ox\u00edgeno aumenta en la EA y respalda el concepto de que el cerebro est\u00e1 bajo un mayor estr\u00e9s oxidativo en la EA.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gabbita, S. P., Lovell, M. A., &amp; Markesbery, W. R. (1998).\u00a0Increased nuclear DNA oxidation in the brain in Alzheimer&#8217;s disease.\u00a0Journal of neurochemistry, 71(5), 2034-2040.\u00a0 FONDO: M\u00faltiples l\u00edneas de evidencia indican que el estr\u00e9s oxidativo contribuye a la muerte neuronal en la enfermedad de Alzheimer (EA). El da\u00f1o oxidativo que se produce en el ADN puede [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-37325","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Aumento de la oxidaci\u00f3n del ADN nuclear en el cerebro en la enfermedad de Alzheimer&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=37325\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Aumento de la oxidaci\u00f3n del ADN nuclear en el cerebro en la enfermedad de Alzheimer&quot; -\" \/>\n<meta property=\"og:description\" content=\"Gabbita, S. P., Lovell, M. A., &amp; Markesbery, W. R. (1998).\u00a0Increased nuclear DNA oxidation in the brain in Alzheimer&#8217;s disease.\u00a0Journal of neurochemistry, 71(5), 2034-2040.\u00a0 FONDO: M\u00faltiples l\u00edneas de evidencia indican que el estr\u00e9s oxidativo contribuye a la muerte neuronal en la enfermedad de Alzheimer (EA). El da\u00f1o oxidativo que se produce en el ADN puede [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=37325\" \/>\n<meta property=\"article:published_time\" content=\"2020-02-20T00:30:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-uC36QfW9DcI\/Xkl2G3G4YfI\/AAAAAAAAaxA\/idLDU1rqMpAqH01KjdUy5QHaJPXbriroACLcBGAsYHQ\/s320\/Journal_Neurochemistry.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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