{"id":37337,"date":"2020-02-20T06:30:10","date_gmt":"2020-02-20T05:30:10","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=37337"},"modified":"2020-02-20T06:30:10","modified_gmt":"2020-02-20T05:30:10","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-mejora-de-deficits-cognitivos-y-neurodegeneracion-por-curcumina-en-modelo-de-rata-de-demencia-esporadica-de-tipo-alzheimer-sda","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=37337","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abMejora de d\u00e9ficits cognitivos y neurodegeneraci\u00f3n por curcumina en modelo de rata de demencia espor\u00e1dica de tipo Alzheimer (SDAT)\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-1cpQM9ZyxlA\/XkmC-0cI_dI\/AAAAAAAAaxo\/yA34dL5ivygkfAt8l91aRCHASIfm-PjuACLcBGAsYHQ\/s1600\/European_Neuropsychopharmacology.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-1cpQM9ZyxlA\/XkmC-0cI_dI\/AAAAAAAAaxo\/yA34dL5ivygkfAt8l91aRCHASIfm-PjuACLcBGAsYHQ\/s1600\/European_Neuropsychopharmacology.jpg\" border=\"0\" data-original-width=\"198\" data-original-height=\"264\" \/><\/a>Ishrat, T., Hoda, M. N., Khan, M. B., Yousuf, S., Ahmad, M., Khan, M. M., &#8230; &amp; Islam, F. (2009).\u00a0<a href=\"https:\/\/s3.amazonaws.com\/academia.edu.documents\/50924113\/j.euroneuro.2009.02.00220161216-32402-1nceuaw.pdf?response-content-disposition=inline%3B%20filename%3DAmelioration_of_cognitive_deficits_and_n.pdf&amp;X-Amz-Algorithm=AWS4-HMAC-SHA256&amp;X-Amz-Credential=AKIAIWOWYYGZ2Y53UL3A%2F20200216%2Fus-east-1%2Fs3%2Faws4_request&amp;X-Amz-Date=20200216T175441Z&amp;X-Amz-Expires=3600&amp;X-Amz-SignedHeaders=host&amp;X-Amz-Signature=9987cc1921a838bf304d91d317af345a21d3899fae22b21cee4d68f564a30854\">Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer&#8217;s type (SDAT).\u00a0<\/a><i>European Neuropsychopharmacology<\/i>, 19(9), 636-647.\u00a0<\/p>\n<p>FONDO: La evidencia reciente indica que la curcumina (CUR), el principal curcuminoide de la c\u00farcuma, exhibe potencial antioxidante y protege al cerebro contra varios estresores oxidativos.\u00a0<\/p>\n<p>OBJETIVO: El objetivo del presente estudio fue examinar los efectos moduladores de la CUR contra los d\u00e9ficits cognitivos y el da\u00f1o oxidativo en ratas infundidas con estreptozotocina intracerebroventricular (ICV-STZ).\u00a0<\/p>\n<p>MATERIALES Y M\u00c9TODO: Las ratas fueron inyectadas bilateralmente con ICV-STZ (3 mg \/ kg), mientras que las ratas simuladas recibieron el mismo volumen de veh\u00edculo y luego se suplementaron con CUR (80 mg \/ kg) durante tres semanas. Despu\u00e9s de dos semanas de infusi\u00f3n de ICV-STZ, se evalu\u00f3 el rendimiento cognitivo de las ratas mediante tareas de evitaci\u00f3n pasiva y laberinto de agua y luego se sacrificaron por ensayos bioqu\u00edmicos e histopatol\u00f3gicos.\u00a0<\/p>\n<p>RESULTADOS: Las ratas ICV-STZ mostraron d\u00e9ficits cognitivos significativos, que mejoraron significativamente con la suplementaci\u00f3n con CUR. La suplementaci\u00f3n con CUR aument\u00f3 significativamente el aumento de 4-hidroxinenal (4-HNE) y malonaldeh\u00eddo (MDA), sustancias reactivas tiobarbit\u00faricas (TBARS), per\u00f3xido de hidr\u00f3geno (H2O2), prote\u00edna carbonilo (PC) y glutati\u00f3n oxidado (GSSG); disminuci\u00f3n de los niveles de glutati\u00f3n reducido (GSH) y sus enzimas dependientes (glutati\u00f3n peroxidasa [GPx] y glutati\u00f3n reductasa [GR]) en el hipocampo y la corteza cerebral; y aumento de la actividad de la colina acetiltransferasa (ChAT) en el hipocampo de las ratas ICV-STZ.\u00a0<\/p>\n<p>CONCLUSI\u00d3N: El estudio sugiere que el CUR es efectivo para prevenir los d\u00e9ficits cognitivos y podr\u00eda ser beneficioso para el tratamiento de la demencia espor\u00e1dica de tipo Alzheimer (SDAT).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ishrat, T., Hoda, M. N., Khan, M. B., Yousuf, S., Ahmad, M., Khan, M. M., &#8230; &amp; Islam, F. (2009).\u00a0Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer&#8217;s type (SDAT).\u00a0European Neuropsychopharmacology, 19(9), 636-647.\u00a0 FONDO: La evidencia reciente indica que la curcumina (CUR), el principal curcuminoide de la c\u00farcuma, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-37337","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Mejora de d\u00e9ficits cognitivos y neurodegeneraci\u00f3n por curcumina en modelo de rata de demencia espor\u00e1dica de tipo Alzheimer (SDAT)&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=37337\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Mejora de d\u00e9ficits cognitivos y neurodegeneraci\u00f3n por curcumina en modelo de rata de demencia espor\u00e1dica de tipo Alzheimer (SDAT)&quot; -\" \/>\n<meta property=\"og:description\" content=\"Ishrat, T., Hoda, M. 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(2009).\u00a0Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer&#8217;s type (SDAT).\u00a0European Neuropsychopharmacology, 19(9), 636-647.\u00a0 FONDO: La evidencia reciente indica que la curcumina (CUR), el principal curcuminoide de la c\u00farcuma, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=37337\" \/>\n<meta property=\"article:published_time\" content=\"2020-02-20T05:30:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-1cpQM9ZyxlA\/XkmC-0cI_dI\/AAAAAAAAaxo\/yA34dL5ivygkfAt8l91aRCHASIfm-PjuACLcBGAsYHQ\/s1600\/European_Neuropsychopharmacology.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" 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