{"id":37610,"date":"2020-02-27T02:30:13","date_gmt":"2020-02-27T01:30:13","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=37610"},"modified":"2020-02-27T02:30:13","modified_gmt":"2020-02-27T01:30:13","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-iefecto-anti-warburg-del-acido-rosmarinico-a-traves-de-mir-155-en-celulas-de-cancer-gastrico","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=37610","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEfecto anti-Warburg del \u00e1cido rosmar\u00ednico a trav\u00e9s de miR-155 en c\u00e9lulas de c\u00e1ncer g\u00e1strico\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-eds55MJMipA\/XlaN8lvq8KI\/AAAAAAAAa9Y\/pIL3-pGgyWcMcruJua3mARF65MYmYqSfwCLcBGAsYHQ\/s1600\/Drug_design_development_therapy.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-eds55MJMipA\/XlaN8lvq8KI\/AAAAAAAAa9Y\/pIL3-pGgyWcMcruJua3mARF65MYmYqSfwCLcBGAsYHQ\/s1600\/Drug_design_development_therapy.jpg\" border=\"0\" data-original-width=\"221\" data-original-height=\"285\" \/><\/a>Han, S., Yang, S., Cai, Z., Pan, D., Li, Z., Huang, Z., &#8230; &amp; Wang, W. (2015).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4445698\/\">Anti-Warburg effect of rosmarinic acid via miR-155 in gastric cancer cells<\/a>.\u00a0<i>Drug design, development and therapy,<\/i>\u00a09, 2695.\u00a0<\/p>\n<p>ANTECEDENTES: El efecto Warburg se refiere a la producci\u00f3n glucol\u00edtica de trifosfato de adenosina en condiciones aer\u00f3bicas, y es una propiedad universal de la mayor\u00eda de las c\u00e9lulas cancerosas. La inflamaci\u00f3n cr\u00f3nica es un factor clave que promueve el efecto Warburg. Este estudio tuvo como objetivo determinar si el \u00e1cido rosmar\u00ednico (AR) tiene un efecto anti-Warburg en el carcinoma g\u00e1strico in vitro e in vivo. El mecanismo para el efecto anti-Warburg tambi\u00e9n fue investigado.<\/p>\n<p>M\u00c9TODOS: Se us\u00f3 un ensayo MTT para examinar el crecimiento celular MKN45 in vitro. Se us\u00f3 un ensayo inmunosorbente ligado a enzimas para detectar citocinas proinflamatorias. La reacci\u00f3n en cadena de la polimerasa en tiempo real se utiliz\u00f3 para evaluar los niveles de expresi\u00f3n de microARN en las c\u00e9lulas. La expresi\u00f3n de prote\u00ednas se determin\u00f3 mediante ensayo de transferencia Western. Se establecieron modelos de xenoinjerto de rat\u00f3n usando c\u00e9lulas MKN45 para evaluar el efecto anti-Warburg en el carcinoma g\u00e1strico in vivo.<\/p>\n<p>RESULTADOS: RA suprimi\u00f3 la absorci\u00f3n de glucosa y la producci\u00f3n de lactato. Tambi\u00e9n inhibi\u00f3 la expresi\u00f3n del factor de transcripci\u00f3n inducible por hipoxia factor-1\u03b1, que afecta la v\u00eda glucol\u00edtica. La inflamaci\u00f3n promovi\u00f3 el efecto Warburg en las c\u00e9lulas cancerosas. Como se esperaba, la AR inhibi\u00f3 las citocinas proinflamatorias y los microARN relacionados con la inflamaci\u00f3n, lo que sugiere que la AR puede suprimir el efecto de Warburg a trav\u00e9s de una v\u00eda inflamatoria, como la que involucra el transductor de interleucina (IL) -6 \/ se\u00f1al y el activador de la transcripci\u00f3n-3 (STAT3). Se descubri\u00f3 que miR-155 es un mediador importante en la relaci\u00f3n entre inflamaci\u00f3n y tumorig\u00e9nesis. Adem\u00e1s, demostramos que miR-155 era el gen diana que regulaba el efecto Warburg mediante la inactivaci\u00f3n de la v\u00eda IL-6 \/ STAT3. Adem\u00e1s, encontramos que RA suprimi\u00f3 el efecto Warburg in vivo.<\/p>\n<p>CONCLUSI\u00d3N: La AR podr\u00eda ser un agente terap\u00e9utico para suprimir el efecto de Warburg en el carcinoma g\u00e1strico.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Han, S., Yang, S., Cai, Z., Pan, D., Li, Z., Huang, Z., &#8230; &amp; Wang, W. (2015).\u00a0Anti-Warburg effect of rosmarinic acid via miR-155 in gastric cancer cells.\u00a0Drug design, development and therapy,\u00a09, 2695.\u00a0 ANTECEDENTES: El efecto Warburg se refiere a la producci\u00f3n glucol\u00edtica de trifosfato de adenosina en condiciones aer\u00f3bicas, y es una propiedad universal de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-37610","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Efecto anti-Warburg del \u00e1cido rosmar\u00ednico a trav\u00e9s de miR-155 en c\u00e9lulas de c\u00e1ncer g\u00e1strico&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=37610\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Efecto anti-Warburg del \u00e1cido rosmar\u00ednico a trav\u00e9s de miR-155 en c\u00e9lulas de c\u00e1ncer g\u00e1strico&quot; -\" \/>\n<meta property=\"og:description\" content=\"Han, S., Yang, S., Cai, Z., Pan, D., Li, Z., Huang, Z., &#8230; &amp; Wang, W. 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