{"id":37934,"date":"2020-03-05T06:30:43","date_gmt":"2020-03-05T05:30:43","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=37934"},"modified":"2020-03-05T06:30:43","modified_gmt":"2020-03-05T05:30:43","slug":"37934","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=37934","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa capsaicina reduce la carga metast\u00e1sica en el adenocarcinoma transg\u00e9nico del modelo de pr\u00f3stata de rat\u00f3n\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-_LfxE2jjxr8\/XmE9XxgtCHI\/AAAAAAAAbLY\/hEMrn7hXRRosFkguut9tml4A1bi72O0WwCLcBGAsYHQ\/s1600\/Prostate.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-_LfxE2jjxr8\/XmE9XxgtCHI\/AAAAAAAAbLY\/hEMrn7hXRRosFkguut9tml4A1bi72O0WwCLcBGAsYHQ\/s1600\/Prostate.jpg\" border=\"0\" data-original-width=\"101\" data-original-height=\"131\" \/><\/a>Venier, N. A., Yamamoto, T., Sugar, L. M., Adomat, H., Fleshner, N. E., Klotz, L. H., &amp; Venkateswaran, V. (2015).\u00a0<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/pros.23013\">Capsaicin reduces the metastatic burden in the transgenic adenocarcinoma of the mouse prostate model.<\/a>\u00a0<i>The Prostate<\/i>, 75(12), 1300-1311.<\/p>\n<p>ANTECEDENTES:\u00a0La capsaicina, el compuesto activo en los chiles, ha demostrado propiedades anticancer\u00edgenas in vitro en una serie de tumores malignos, incluida la pr\u00f3stata. En el presente estudio, investigamos el potencial quimiopreventivo de la capsaicina en el c\u00e1ncer de pr\u00f3stata utilizando el modelo de adenocarcinoma transg\u00e9nico de pr\u00f3stata de rat\u00f3n (TRAMP). El TRAMP es un modelo murino que se asemeja a la progresi\u00f3n de la enfermedad humana.<\/p>\n<div>\nM\u00c9TODOS:\u00a0Treinta y cinco ratones TRAMP x C57BL \/ 6 de 6 semanas de edad se asignaron al azar entre el tratamiento con capsaicina (5 mg \/ kg de peso corporal) o el control (soluci\u00f3n salina) tres veces por semana por sonda oral hasta las 30 semanas de edad. El peso corporal de los animales se registr\u00f3 tres veces por semana. Al finalizar, todos los tumores se extrajeron, registraron y analizaron para el an\u00e1lisis histopatol\u00f3gico. Para comprender el efecto de la capsaicina sobre la migraci\u00f3n y la invasi\u00f3n, se realizaron experimentos in vitro utilizando c\u00e9lulas PC3.<\/div>\n<div>\u00a0<\/div>\n<div>RESULTADOS: Los ratones en el grupo control expresaron una tendencia general de enfermedad de grado superior con 37.5% pobremente diferenciado (PD), 18.75% moderadamente diferenciado (MD) y 44% de adenocarcinoma bien diferenciado (WD), en comparaci\u00f3n con el grupo tratado con capsaicina con solo 27.7% de EP, 61.0% de WD y 11.1% de neoplasia intraepitelial (PIN). El grupo de tratamiento demostr\u00f3 una mayor incidencia de lesiones PIN no cancerosas en comparaci\u00f3n con el grupo control. El grupo de capsaicina tambi\u00e9n demostr\u00f3 una reducci\u00f3n significativa ( P \u2009&lt;0.05) en la carga metast\u00e1sica en comparaci\u00f3n con los controles, lo que se correlacion\u00f3 con una reducci\u00f3n en p27 Kip 1expresi\u00f3n y diferenciaci\u00f3n neuroendocrina en tumores de pr\u00f3stata. Adem\u00e1s, no hubo diferencias en el peso corporal entre los grupos de tiempo extra, y no hubo toxicidades patol\u00f3gicas en el h\u00edgado y el tracto gastrointestinal con el consumo de capsaicina. Los estudios in vitro revelaron una reducci\u00f3n dependiente de la dosis en la capacidad de invasi\u00f3n y migraci\u00f3n de las c\u00e9lulas PC3.<\/div>\n<div>\u00a0<\/div>\n<div>CONCLUSI\u00d3N: El siguiente estudio proporciona evidencia que respalda los efectos de seguridad y quimiopreventivos de la capsaicina en el modelo.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Venier, N. A., Yamamoto, T., Sugar, L. M., Adomat, H., Fleshner, N. E., Klotz, L. H., &amp; Venkateswaran, V. (2015).\u00a0Capsaicin reduces the metastatic burden in the transgenic adenocarcinoma of the mouse prostate model.\u00a0The Prostate, 75(12), 1300-1311. ANTECEDENTES:\u00a0La capsaicina, el compuesto activo en los chiles, ha demostrado propiedades anticancer\u00edgenas in vitro en una serie de tumores [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-37934","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La capsaicina reduce la carga metast\u00e1sica en el adenocarcinoma transg\u00e9nico del modelo de pr\u00f3stata de rat\u00f3n&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=37934\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La capsaicina reduce la carga metast\u00e1sica en el adenocarcinoma transg\u00e9nico del modelo de pr\u00f3stata de rat\u00f3n&quot; -\" \/>\n<meta property=\"og:description\" content=\"Venier, N. A., Yamamoto, T., Sugar, L. M., Adomat, H., Fleshner, N. E., Klotz, L. H., &amp; Venkateswaran, V. (2015).\u00a0Capsaicin reduces the metastatic burden in the transgenic adenocarcinoma of the mouse prostate model.\u00a0The Prostate, 75(12), 1300-1311. 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adenocarcinoma transg\u00e9nico del modelo de pr\u00f3stata de rat\u00f3n\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=37934","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La capsaicina reduce la carga metast\u00e1sica en el adenocarcinoma transg\u00e9nico del modelo de pr\u00f3stata de rat\u00f3n\" -","og_description":"Venier, N. 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