{"id":37992,"date":"2020-03-07T00:30:21","date_gmt":"2020-03-06T23:30:21","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=37992"},"modified":"2020-03-07T00:30:21","modified_gmt":"2020-03-06T23:30:21","slug":"37992","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=37992","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa nobiletina de flavonoides c\u00edtricos confiere protecci\u00f3n contra la desregulaci\u00f3n metab\u00f3lica en ratones alimentados con alto contenido de grasa independientemente de AMPK\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-l0LlCI1Wdjg\/XmNe_EiKA9I\/AAAAAAAAbNw\/yLIsVFql9WwENdlfHcjJT0WEIVo4kJqVACLcBGAsYHQ\/s1600\/Journal_Lipid%2BResearch.gif\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-l0LlCI1Wdjg\/XmNe_EiKA9I\/AAAAAAAAbNw\/yLIsVFql9WwENdlfHcjJT0WEIVo4kJqVACLcBGAsYHQ\/s1600\/Journal_Lipid%2BResearch.gif\" border=\"0\" data-original-width=\"185\" data-original-height=\"240\" \/><\/a>Morrow, N. M., Burke, A. C., Samsoondar, J. P., Seigel, K. E., Wang, A., Telford, D. E., &#8230; &amp; Huff, M. W. (2020).\u00a0<a href=\"https:\/\/www.jlr.org\/content\/early\/2020\/01\/21\/jlr.RA119000542.full.pdf\">The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK.<\/a>\u00a0<i>Journal of Lipid Research<\/i>, 61(3), 387-402.<\/p>\n<p>CONTEXTO: La obesidad, la dislipidemia y la resistencia a la insulina, el s\u00edndrome metab\u00f3lico cada vez m\u00e1s com\u00fan, son factores de riesgo de ECV y diabetes tipo 2 que justifican nuevas intervenciones terap\u00e9uticas. El flavonoide nobiletina muestra potentes propiedades hipolipemiantes y sensibilizadoras a la insulina en ratones con disfunci\u00f3n metab\u00f3lica. Sin embargo, los mecanismos por los cuales la nobiletina media la protecci\u00f3n metab\u00f3lica no est\u00e1n claramente establecidos. El papel central de la prote\u00edna quinasa activada por AMP (AMPK) como sensor de energ\u00eda sugiere que AMPK es un objetivo de la nobiletina.\u00a0<\/p>\n<p>OBJETIVO: Probamos la hip\u00f3tesis de que la protecci\u00f3n metab\u00f3lica con nobiletina requer\u00eda la fosforilaci\u00f3n de AMPK y acetil-CoA carboxilasa (ACC) en hepatocitos de rat\u00f3n, en ratones deficientes en AMPK hep\u00e1tica (Ampk\u03b21 &#8211; \/ &#8211; ), en ratones incapaces de la fosforilaci\u00f3n inhibitoria de ACC ( AccDKI ), y en ratones con deficiencia de AMPK espec\u00edfica de adipocitos ( i\u03b21\u03b22AKO ).\u00a0<\/p>\n<p>M\u00c9TODO: Alimentamos a los ratones con una dieta alta en grasas \/ colesterol con o sin nobiletina.\u00a0<\/p>\n<p>RESULTADOS: La nobiletina aument\u00f3 la fosforilaci\u00f3n de AMPK y ACC en los hepatocitos primarios de rat\u00f3n, lo que se asoci\u00f3 con un aumento de la oxidaci\u00f3n de FA y la s\u00edntesis atenuada de FA. A pesar de la p\u00e9rdida de fosforilaci\u00f3n de ACC en Ampk\u03b21 &#8211; \/ -hepatocitos, nobiletina suprimi\u00f3 la s\u00edntesis de FA y mejor\u00f3 la oxidaci\u00f3n de FA. La inyecci\u00f3n aguda de nobiletina en ratones no aument\u00f3 la fosforilaci\u00f3n de AMPK o ACC en el h\u00edgado. En ratones alimentados con una dieta alta en grasas, la nobiletina previno de manera s\u00f3lida la obesidad, la esteatosis hep\u00e1tica, la dislipidemia y la resistencia a la insulina, y mejor\u00f3 el gasto de energ\u00eda en Ampk\u03b21 &#8211; \/ &#8211; , AccDKI e i\u03b21\u03b22AKOratones en la misma medida que en los controles WT.\u00a0<\/p>\n<p>CONCLUSI\u00d3N: Por lo tanto, los efectos metab\u00f3licos beneficiosos de la nobiletina in vivo se confieren independientemente de la activaci\u00f3n de la AMPK hep\u00e1tica o adipocitaria. Estos estudios subrayan a\u00fan m\u00e1s el potencial terap\u00e9utico de la nobiletina y comienzan a aclarar los posibles mecanismos.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Morrow, N. M., Burke, A. C., Samsoondar, J. P., Seigel, K. E., Wang, A., Telford, D. E., &#8230; &amp; Huff, M. W. (2020).\u00a0The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK.\u00a0Journal of Lipid Research, 61(3), 387-402. CONTEXTO: La obesidad, la dislipidemia y la resistencia a la insulina, el s\u00edndrome [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-37992","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La nobiletina de flavonoides c\u00edtricos confiere protecci\u00f3n contra la desregulaci\u00f3n metab\u00f3lica en ratones alimentados con alto contenido de grasa independientemente de AMPK&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=37992\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La nobiletina de flavonoides c\u00edtricos confiere protecci\u00f3n contra la desregulaci\u00f3n metab\u00f3lica en ratones alimentados con alto contenido de grasa independientemente de AMPK&quot; -\" \/>\n<meta property=\"og:description\" content=\"Morrow, N. M., Burke, A. C., Samsoondar, J. P., Seigel, K. E., Wang, A., Telford, D. E., &#8230; &amp; Huff, M. W. (2020).\u00a0The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK.\u00a0Journal of Lipid Research, 61(3), 387-402. CONTEXTO: La obesidad, la dislipidemia y la resistencia a la insulina, el s\u00edndrome [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=37992\" \/>\n<meta property=\"article:published_time\" content=\"2020-03-06T23:30:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-l0LlCI1Wdjg\/XmNe_EiKA9I\/AAAAAAAAbNw\/yLIsVFql9WwENdlfHcjJT0WEIVo4kJqVACLcBGAsYHQ\/s1600\/Journal_Lipid%2BResearch.gif\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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