{"id":37995,"date":"2020-03-07T01:30:53","date_gmt":"2020-03-07T00:30:53","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=37995"},"modified":"2020-03-07T01:30:53","modified_gmt":"2020-03-07T00:30:53","slug":"37995","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=37995","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abIntervenci\u00f3n con c\u00edtricos flavonoides reveses obesidad y mejora el s\u00edndrome metab\u00f3lico y la aterosclerosis en los obesos LDLR &#8211; \/ &#8211; ratones\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-pMsDLtQOhJ0\/XmNgtaCIwfI\/AAAAAAAAbN4\/tRLJUqFDBMszcFKlGmjOJD-M8yhUrlVagCLcBGAsYHQ\/s1600\/Journal_lipid%2Bresearch2.gif\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-pMsDLtQOhJ0\/XmNgtaCIwfI\/AAAAAAAAbN4\/tRLJUqFDBMszcFKlGmjOJD-M8yhUrlVagCLcBGAsYHQ\/s1600\/Journal_lipid%2Bresearch2.gif\" border=\"0\" data-original-width=\"185\" data-original-height=\"240\" \/><\/a>Burke, A. C., Sutherland, B. G., Telford, D. E., Morrow, M. R., Sawyez, C. G., Edwards, J. Y., &#8230; &amp; Huff, M. W. (2018).\u00a0<a href=\"https:\/\/www.jlr.org\/content\/59\/9\/1714.full.pdf\">Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr\u2212\/\u2212 mice<\/a>.\u00a0<i>Journal of lipid research<\/i>, 59(9), 1714-1728.<\/p>\n<p>CONTEXTO: La obesidad y su disfunci\u00f3n metab\u00f3lica asociada y el riesgo de enfermedad cardiovascular representan una causa principal de morbilidad en adultos en todo el mundo. Las terapias farmacol\u00f3gicas disponibles actualmente para la obesidad han tenido un \u00e9xito limitado en revertir la obesidad existente y la desregulaci\u00f3n metab\u00f3lica. Estudios previos de prevenci\u00f3n demostraron que los flavonoides c\u00edtricos, naringenina y nobiletina, protegen contra la obesidad y la disfunci\u00f3n metab\u00f3lica en ratones Ldlr &#8211; \/ &#8211; alimentados con una dieta alta en grasas que contiene colesterol (HFHC). Sin embargo, sus efectos en un modelo de intervenci\u00f3n son desconocidos.\u00a0<\/p>\n<p>RESULTADOS: En este informe, mostramos que, en Ldlr &#8211; \/ -ratones con obesidad inducida por la dieta, la suplementaci\u00f3n con flavonoides c\u00edtricos a una dieta HFHC revirti\u00f3 la obesidad y el tama\u00f1o y n\u00famero de adipocitos existentes a trav\u00e9s de un mayor gasto de energ\u00eda y una mayor oxidaci\u00f3n de \u00e1cidos grasos hep\u00e1ticos. La ingesta cal\u00f3rica no se vio afectada y no se observ\u00f3 evidencia de ennegrecimiento del tejido adiposo blanco. La reversi\u00f3n de la adiposidad estuvo acompa\u00f1ada de mejoras en la hiperlipidemia, sensibilidad a la insulina, esteatosis hep\u00e1tica y una reducci\u00f3n moderada en los monocitos sangu\u00edneos. Juntos, esto result\u00f3 en lesiones ateroscler\u00f3ticas que no cambiaron de tama\u00f1o, pero se caracterizaron por un contenido reducido de macr\u00f3fagos, consistente con un fenotipo de placa m\u00e1s estable.\u00a0<\/p>\n<p>CONCLUSI\u00d3N: Estos estudios sugieren adem\u00e1s la potencial utilidad terap\u00e9utica de los flavonoides c\u00edtricos, especialmente en el contexto de la obesidad existente, la disfunci\u00f3n metab\u00f3lica y las enfermedades cardiovasculares.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Burke, A. C., Sutherland, B. G., Telford, D. E., Morrow, M. R., Sawyez, C. G., Edwards, J. Y., &#8230; &amp; Huff, M. W. (2018).\u00a0Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr\u2212\/\u2212 mice.\u00a0Journal of lipid research, 59(9), 1714-1728. CONTEXTO: La obesidad y su disfunci\u00f3n metab\u00f3lica asociada y el riesgo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-37995","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Intervenci\u00f3n con c\u00edtricos flavonoides reveses obesidad y mejora el s\u00edndrome metab\u00f3lico y la aterosclerosis en los obesos LDLR - \/ - ratones&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=37995\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Intervenci\u00f3n con c\u00edtricos flavonoides reveses obesidad y mejora el s\u00edndrome metab\u00f3lico y la aterosclerosis en los obesos LDLR - \/ - ratones&quot; -\" \/>\n<meta property=\"og:description\" content=\"Burke, A. C., Sutherland, B. G., Telford, D. E., Morrow, M. R., Sawyez, C. G., Edwards, J. Y., &#8230; &amp; Huff, M. W. (2018).\u00a0Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr\u2212\/\u2212 mice.\u00a0Journal of lipid research, 59(9), 1714-1728. 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