{"id":38002,"date":"2020-03-07T03:30:03","date_gmt":"2020-03-07T02:30:03","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=38002"},"modified":"2020-03-07T03:30:03","modified_gmt":"2020-03-07T02:30:03","slug":"38002","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=38002","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abDirigirse a m\u00faltiples mecanismos patog\u00e9nicos con polifenoles para el tratamiento del enfoque experimental de la enfermedad de Alzheimer y las implicaciones terap\u00e9uticas\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-F7Y7qRhFshg\/XmNnf_rKF6I\/AAAAAAAAbOI\/dH7q9V-yUYw8JEclpLxHRu7hv2WwCtfswCLcBGAsYHQ\/s1600\/Frontiers_Aging_Neuroscience.png\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-F7Y7qRhFshg\/XmNnf_rKF6I\/AAAAAAAAbOI\/dH7q9V-yUYw8JEclpLxHRu7hv2WwCtfswCLcBGAsYHQ\/s1600\/Frontiers_Aging_Neuroscience.png\" border=\"0\" data-original-width=\"200\" data-original-height=\"200\" \/><\/a>Wang, J., Bi, W., Cheng, A., Freire, D., Vempati, P., Zhao, W., &#8230; &amp; Schmeidler, J. (2014).\u00a0<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2014.00042\/full\">Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer&#8217;s disease-experimental approach and therapeutic implications<\/a>.\u00a0<i>Frontiers in aging neuroscience<\/i>, 6, 42.<\/p>\n<p>FONDO: La enfermedad de Alzheimer (EA) es la enfermedad neurodegenerativa m\u00e1s frecuente del envejecimiento y actualmente no tiene cura. Su inicio y progresi\u00f3n est\u00e1n influenciados por m\u00faltiples factores. Existe un consenso cada vez mayor de que el tratamiento exitoso depender\u00e1 de la identificaci\u00f3n simult\u00e1nea de m\u00faltiples caracter\u00edsticas patol\u00f3gicas de la EA. Los compuestos de polifenoles tienen muchos beneficios comprobados para la salud.\u00a0<\/p>\n<p>OBJETIVO \/ M\u00c9TODO: En este estudio, probamos la hip\u00f3tesis de que combinar tres preparaciones polifen\u00f3licas (extracto de semilla de uva, resveratrol y extracto de jugo de uva Concord), con diferentes composiciones polifen\u00f3licas y bioactividades parcialmente redundantes, puede mitigar simult\u00e1neamente y sin\u00e9rgicamente la neuropatolog\u00eda mediada por amiloide-\u03b2 (A\u03b2) y deficiencias cognitivas en un modelo de rat\u00f3n con EA.\u00a0<\/p>\n<p>RESULTADOS: Encontramos que la administraci\u00f3n de los polifenoles en combinaci\u00f3n no alter\u00f3 el perfil de los metabolitos de polifenoles bioactivos en el cerebro. Tambi\u00e9n descubrimos que el tratamiento combinado result\u00f3 en una mejor protecci\u00f3n contra el deterioro cognitivo en comparaci\u00f3n con los tratamientos individuales, en ratones J20 AD. El examen electrofisiol\u00f3gico mostr\u00f3 que el tratamiento agudo con metabolitos seleccionados de polifenoles penetrantes en el cerebro, derivados de estos polifenoles, mejoraba los d\u00e9ficits de potenciaci\u00f3n a largo plazo (LTP) inducidos por A\u03b2 (oA\u03b2) oligom\u00e9ricos en cortes del hipocampo. Adem\u00e1s, encontramos un contenido de amiloide total muy reducido en el cerebro despu\u00e9s del tratamiento combinado.\u00a0<\/p>\n<p>CONCLUSI\u00d3N: Nuestros estudios proporcionaron evidencia experimental de que la aplicaci\u00f3n de polifenoles dirigidos a m\u00faltiples mecanismos de la enfermedad puede producir una mayor probabilidad de eficacia terap\u00e9utica.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wang, J., Bi, W., Cheng, A., Freire, D., Vempati, P., Zhao, W., &#8230; &amp; Schmeidler, J. (2014).\u00a0Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer&#8217;s disease-experimental approach and therapeutic implications.\u00a0Frontiers in aging neuroscience, 6, 42. FONDO: La enfermedad de Alzheimer (EA) es la enfermedad neurodegenerativa m\u00e1s frecuente del envejecimiento y actualmente no tiene [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-38002","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Dirigirse a m\u00faltiples mecanismos patog\u00e9nicos con polifenoles para el tratamiento del enfoque experimental de la enfermedad de Alzheimer y las implicaciones terap\u00e9uticas&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=38002\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Dirigirse a m\u00faltiples mecanismos patog\u00e9nicos con polifenoles para el tratamiento del enfoque experimental de la enfermedad de Alzheimer y las implicaciones terap\u00e9uticas&quot; -\" \/>\n<meta property=\"og:description\" content=\"Wang, J., Bi, W., Cheng, A., Freire, D., Vempati, P., Zhao, W., &#8230; &amp; Schmeidler, J. 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