{"id":38034,"date":"2020-03-09T06:30:16","date_gmt":"2020-03-09T05:30:16","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=38034"},"modified":"2020-03-09T06:30:16","modified_gmt":"2020-03-09T05:30:16","slug":"38034","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=38034","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abPotencial terap\u00e9utico de Naringina para la degeneraci\u00f3n del disco intervertebral: participaci\u00f3n de la autofagia contra la apoptosis inducida por estr\u00e9s oxidativo en las c\u00e9lulas del n\u00facleo pulposo"},"content":{"rendered":"<p><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-A-pwbv3UK9Q\/XmOgKTYDywI\/AAAAAAAAbPc\/ZPnr9BtPY-w-z6_cqqsoTttntoPRzTPVwCEwYBhgL\/s320\/American_journal_Chinese_medicine.jpg\" \/>Zhang, Z., Wang, C., Lin, J., Jin, H., Wang, K., Yan, Y., &#8230; &amp; Wang, X. (2018). <a href=\"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0192415X18500805?utm_source=TrendMD&amp;utm_medium=cpc&amp;utm_campaign=The_American_Journal_of_Chinese_Medicine_TrendMD_0\">Therapeutic potential of naringin for intervertebral disc degeneration: involvement of autophagy against oxidative stress-induced apoptosis in nucleus pulposus cells<\/a>.\u00a0<i>The American journal of Chinese medicine<\/i>, 46(07), 1561-1580.<\/p>\n<p>CONTEXTO: La degeneraci\u00f3n del disco intervertebral (IDD) es una causa importante de dolor lumbar, pero se han desarrollado pocos medicamentos eficaces para la IDD. El aumento de la apoptosis de las c\u00e9lulas del n\u00facleo pulposo es una patog\u00e9nesis dominante de IDD y se considera un objetivo terap\u00e9utico. Anteriormente, nuestro grupo demostr\u00f3 que la autofagia puede proteger las c\u00e9lulas del n\u00facleo pulposo contra la apoptosis. Como uno de los principales bioflavonoides de los c\u00edtricos, la naringina activa la autofagia.\u00a0<\/p>\n<p>OBJETIVO: Por lo tanto, planteamos la hip\u00f3tesis de que la naringina puede tener potencial terap\u00e9utico para la IDD al activar la autofagia en las c\u00e9lulas del n\u00facleo pulposo.\u00a0<\/p>\n<p>M\u00c9TODO: En este estudio, evaluamos los efectos de la naringina sobre el estr\u00e9s oxidativo inducido por TBHP en las c\u00e9lulas del n\u00facleo pulposo in vitro , as\u00ed como en el modelo de IDD de rata inducida por punci\u00f3n in vivo.\u00a0<\/p>\n<p>RESULTADOS: Nuestros resultados mostraron que la naringina podr\u00eda reducir la incidencia de apoptosis inducida por estr\u00e9s oxidativo en las c\u00e9lulas del n\u00facleo pulposo y promovi\u00f3 la expresi\u00f3n de marcadores de autofagia LC3-II \/ I y beclin-1. Mientras tanto, la inhibici\u00f3n de la autofagia por 3-MA puede revertir parcialmente el efecto antiapopt\u00f3tico de la naringina, lo que indica que la autofagia estaba involucrada en el efecto protector de la naringina en las c\u00e9lulas del n\u00facleo pulposo. Otros estudios mostraron que la regulaci\u00f3n de la autofagia de naringina puede estar relacionada con la se\u00f1alizaci\u00f3n de AMPK. Adem\u00e1s, encontramos que el tratamiento con naringina puede regular la expresi\u00f3n de col\u00e1geno II, agrecano y Mmp13 para sostener la matriz extracelular. Adem\u00e1s, nuestro in vivo estudio demostr\u00f3 que la naringina puede mejorar la IDD en el modelo de rata inducida por punci\u00f3n.\u00a0<\/p>\n<p>CONCLUSI\u00d3N: En conclusi\u00f3n, nuestro estudio sugiere que la naringina puede proteger las c\u00e9lulas del n\u00facleo pulposo contra la apoptosis y mejorar la IDD in vivo , el mecanismo puede estar relacionado con su regulaci\u00f3n de autofagia.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zhang, Z., Wang, C., Lin, J., Jin, H., Wang, K., Yan, Y., &#8230; &amp; Wang, X. (2018). Therapeutic potential of naringin for intervertebral disc degeneration: involvement of autophagy against oxidative stress-induced apoptosis in nucleus pulposus cells.\u00a0The American journal of Chinese medicine, 46(07), 1561-1580. CONTEXTO: La degeneraci\u00f3n del disco intervertebral (IDD) es una causa importante de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-38034","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Potencial terap\u00e9utico de Naringina para la degeneraci\u00f3n del disco intervertebral: participaci\u00f3n de la autofagia contra la apoptosis inducida por estr\u00e9s oxidativo en las c\u00e9lulas del n\u00facleo pulposo -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=38034\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Potencial terap\u00e9utico de Naringina para la degeneraci\u00f3n del disco intervertebral: participaci\u00f3n de la autofagia contra la apoptosis inducida por estr\u00e9s oxidativo en las c\u00e9lulas del n\u00facleo pulposo -\" \/>\n<meta property=\"og:description\" content=\"Zhang, Z., Wang, C., Lin, J., Jin, H., Wang, K., Yan, Y., &#8230; &amp; Wang, X. (2018). Therapeutic potential of naringin for intervertebral disc degeneration: involvement of autophagy against oxidative stress-induced apoptosis in nucleus pulposus cells.\u00a0The American journal of Chinese medicine, 46(07), 1561-1580. CONTEXTO: La degeneraci\u00f3n del disco intervertebral (IDD) es una causa importante de [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=38034\" \/>\n<meta property=\"article:published_time\" content=\"2020-03-09T05:30:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-A-pwbv3UK9Q\/XmOgKTYDywI\/AAAAAAAAbPc\/ZPnr9BtPY-w-z6_cqqsoTttntoPRzTPVwCEwYBhgL\/s320\/American_journal_Chinese_medicine.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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