{"id":38331,"date":"2020-03-16T03:30:10","date_gmt":"2020-03-16T02:30:10","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=38331"},"modified":"2020-03-16T03:30:10","modified_gmt":"2020-03-16T02:30:10","slug":"38331","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=38331","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abClases celulares en el cerebro humano reveladas in vivo por modulaci\u00f3n relacionada con los latidos del coraz\u00f3n de la forma de onda potencial de acci\u00f3n extracelular\u00bb"},"content":{"rendered":"

<\/a>Mosher, C. P., Wei, Y., Kami\u0144ski, J., Nandi, A., Mamelak, A. N., Anastassiou, C. A., & Rutishauser, U. (2020).\u00a0Cellular Classes in the Human Brain Revealed In Vivo by Heartbeat-Related Modulation of the Extracellular Action Potential Waveform<\/a>.\u00a0Cell Reports<\/i>, 30(10), 3536-3551.<\/p>\n

Determinar los tipos de c\u00e9lulas es fundamental para comprender los circuitos neuronales, pero sigue siendo dif\u00edcil de alcanzar en el cerebro humano vivo. Los enfoques actuales discriminan unidades en clases de c\u00e9lulas putativas utilizando caracter\u00edsticas del potencial de acci\u00f3n extracelular (EAP); en ausencia de datos de verdad b\u00e1sica, este sigue siendo un procedimiento problem\u00e1tico.\u00a0<\/p>\n

Encontramos que los EAP en estructuras profundas del cerebro exhiben una variabilidad robusta y sistem\u00e1tica durante el ciclo card\u00edaco. Estas caracter\u00edsticas relacionadas con el coraz\u00f3n refinan la clasificaci\u00f3n neural.\u00a0<\/p>\n

Utilizamos estas caracter\u00edsticas para vincular modelos biorealistas generados a partir de registros in vitro de c\u00e9lulas enteras humanas de neuronas clasificadas morfol\u00f3gicamente a in vivograbaciones Diferenciamos las neuronas hipocampales humanas inhibidoras de la aspina y las excitadoras espinosas y, en una segunda etapa, demostramos que las caracter\u00edsticas del movimiento card\u00edaco revelan dos tipos de neuronas espinosas con propiedades electrofisiol\u00f3gicas intr\u00ednsecas distintas y caracter\u00edsticas de bloqueo de fase a las oscilaciones end\u00f3genas.\u00a0<\/p>\n

Este enfoque multimodal mejora notablemente la clasificaci\u00f3n celular en humanos, ofrece clases celulares interpretables y es aplicable a otras \u00e1reas y especies del cerebro.<\/p>\n","protected":false},"excerpt":{"rendered":"

Mosher, C. P., Wei, Y., Kami\u0144ski, J., Nandi, A., Mamelak, A. N., Anastassiou, C. A., & Rutishauser, U. (2020).\u00a0Cellular Classes in the Human Brain Revealed In Vivo by Heartbeat-Related Modulation of the Extracellular Action Potential Waveform.\u00a0Cell Reports, 30(10), 3536-3551. Determinar los tipos de c\u00e9lulas es fundamental para comprender los circuitos neuronales, pero sigue siendo dif\u00edcil […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-38331","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"\n\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: "Clases celulares en el cerebro humano reveladas in vivo por modulaci\u00f3n relacionada con los latidos del coraz\u00f3n de la forma de onda potencial de acci\u00f3n extracelular" -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=38331\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: "Clases celulares en el cerebro humano reveladas in vivo por modulaci\u00f3n relacionada con los latidos del coraz\u00f3n de la forma de onda potencial de acci\u00f3n extracelular" -\" \/>\n<meta property=\"og:description\" content=\"Mosher, C. P., Wei, Y., Kami\u0144ski, J., Nandi, A., Mamelak, A. N., Anastassiou, C. A., & Rutishauser, U. (2020).\u00a0Cellular Classes in the Human Brain Revealed In Vivo by Heartbeat-Related Modulation of the Extracellular Action Potential Waveform.\u00a0Cell Reports, 30(10), 3536-3551. Determinar los tipos de c\u00e9lulas es fundamental para comprender los circuitos neuronales, pero sigue siendo dif\u00edcil […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=38331\" \/>\n<meta property=\"article:published_time\" content=\"2020-03-16T02:30:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-S9E5ERmei0M\/Xm6R4aGLRNI\/AAAAAAAAbZk\/AEaFMIss_joMghy1EQcshMo85ZYv8uW3wCLcBGAsYHQ\/s320\/Cell_Reports.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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