{"id":38674,"date":"2020-03-23T01:30:12","date_gmt":"2020-03-23T00:30:12","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=38674"},"modified":"2020-03-23T01:30:12","modified_gmt":"2020-03-23T00:30:12","slug":"38674","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=38674","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abS\u00edntesis y potencial reductor del colesterol del derivado de fitosterol soluble en agua\u00bb"},"content":{"rendered":"

<\/a>He, W. S., Li, L., Wang, H., Rui, J., & Cui, D. (2019).\u00a0Synthesis and cholesterol-reducing potential of water-soluble phytosterol derivative<\/a>.\u00a0Journal of Functional Foods<\/i>, 60, 103428.<\/p>\n

CONTEXTO: Los fitoesteroles han recibido recientemente una atenci\u00f3n considerable. Sin embargo, las aplicaciones de estos l\u00edpidos derivados de plantas est\u00e1n muy limitadas por la insolubilidad en agua y la escasa solubilidad en aceite. La mayor\u00eda de los estudios anteriores se han centrado principalmente en mejorar la solubilidad en aceite de los fitosteroles.<\/p>\n

\n

OBJETIVO \/ M\u00c9TODO: El presente estudio estableci\u00f3 un m\u00e9todo eficiente para sintetizar un derivado de fitosterol soluble en agua (PPGS-1000), empleando [BSO 3HMim] OTf como catalizador. Aqu\u00ed, la conversi\u00f3n de PPGS-1000 super\u00f3 el 94% en un per\u00edodo corto (60 min). La actividad reductora del colesterol de PPGS-1000 se examin\u00f3 m\u00e1s a fondo en ratas Sprague-Dawley alimentadas con una dieta alta en colesterol. Adem\u00e1s, se explor\u00f3 el efecto de PPGS-1000 sobre la expresi\u00f3n de ARNm de genes hep\u00e1ticos implicados en el metabolismo del colesterol.<\/p>\n

RESULTADOS: En ratas, PPGS-1000 redujo significativamente los niveles de colesterol total en suero y de lipoprote\u00edna de baja densidad (LDL-C), LDL-C en suero \/ relaci\u00f3n de colesterol de lipoprote\u00edna de alta densidad y nivel de colesterol en el h\u00edgado en un 10,3%, 33,7%, 35,9% y 25,9%, respectivamente. PPGS-1000 promovi\u00f3 notablemente la excreci\u00f3n de colesterol fecal. Y la expresi\u00f3n de ARNm de HMG-CoR, LDL-R y SREBP-2 en el h\u00edgado se regul\u00f3 despu\u00e9s del tratamiento con PPGS-1000.<\/p>\n

CONCLUSI\u00d3N: En conclusi\u00f3n, PPGS-1000 pose\u00eda un potencial reductor del colesterol.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

He, W. S., Li, L., Wang, H., Rui, J., & Cui, D. (2019).\u00a0Synthesis and cholesterol-reducing potential of water-soluble phytosterol derivative.\u00a0Journal of Functional Foods, 60, 103428. CONTEXTO: Los fitoesteroles han recibido recientemente una atenci\u00f3n considerable. Sin embargo, las aplicaciones de estos l\u00edpidos derivados de plantas est\u00e1n muy limitadas por la insolubilidad en agua y la escasa […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-38674","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"\n\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: "S\u00edntesis y potencial reductor del colesterol del derivado de fitosterol soluble en agua" -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=38674\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: "S\u00edntesis y potencial reductor del colesterol del derivado de fitosterol soluble en agua" -\" \/>\n<meta property=\"og:description\" content=\"He, W. S., Li, L., Wang, H., Rui, J., & Cui, D. (2019).\u00a0Synthesis and cholesterol-reducing potential of water-soluble phytosterol derivative.\u00a0Journal of Functional Foods, 60, 103428. CONTEXTO: Los fitoesteroles han recibido recientemente una atenci\u00f3n considerable. Sin embargo, las aplicaciones de estos l\u00edpidos derivados de plantas est\u00e1n muy limitadas por la insolubilidad en agua y la escasa […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=38674\" \/>\n<meta property=\"article:published_time\" content=\"2020-03-23T00:30:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-XRuIL27uduo\/Xne8yX656YI\/AAAAAAAAbkU\/_Jg4HiWpggkCrjPelCKO_o1IIE9EFf5xgCLcBGAsYHQ\/s1600\/Journal_Functional%2BFoods4.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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del derivado de fitosterol soluble en agua\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=38674","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"S\u00edntesis y potencial reductor del colesterol del derivado de fitosterol soluble en agua\" -","og_description":"He, W. 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