{"id":39108,"date":"2020-04-03T05:30:51","date_gmt":"2020-04-03T03:30:51","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=39108"},"modified":"2020-04-03T05:30:51","modified_gmt":"2020-04-03T03:30:51","slug":"39108","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=39108","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abSulforafano: un inhibidor mit\u00f3tico del carcinoma mamario natural que interrumpe la polimerizaci\u00f3n de la tubulina\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-Ebd-g1cl3TE\/XoeiX4g4a8I\/AAAAAAAAb4Q\/EAmqLJJ_B70JzdzZyZtTQvowtM1Qua1JgCLcBGAsYHQ\/s1600\/Carcinogenesis.png\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-Ebd-g1cl3TE\/XoeiX4g4a8I\/AAAAAAAAb4Q\/EAmqLJJ_B70JzdzZyZtTQvowtM1Qua1JgCLcBGAsYHQ\/s320\/Carcinogenesis.png\" width=\"247\" height=\"320\" border=\"0\" data-original-width=\"520\" data-original-height=\"672\" \/><\/a>Jackson, S. J., &amp; Singletary, K. W. (2004).\u00a0<a href=\"https:\/\/academic.oup.com\/carcin\/article\/25\/2\/219\/2390576\">Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization<\/a>.\u00a0<i>Carcinogenesis<\/i>, 25(2), 219-227.<\/p>\n<p>Se ha demostrado que el sulforafano (SUL), un isotiocianato que se encuentra en el br\u00f3coli y otras verduras cruc\u00edferas, induce enzimas de desintoxicaci\u00f3n de fase II, inhibe los tumores mamarios inducidos qu\u00edmicamente en ratas y, m\u00e1s recientemente, induce la detenci\u00f3n del ciclo celular y la apoptosis en las c\u00e9lulas cancerosas del colon.\u00a0<\/p>\n<p>Aqu\u00ed, proporcionamos evidencia de que SUL tambi\u00e9n act\u00faa como un agente antiproliferativo del c\u00e1ncer de mama. La l\u00ednea celular de carcinoma mamario de rat\u00f3n BALB \/ c F3II se trat\u00f3 con SUL a concentraciones de hasta 15 \u00b5M y se examin\u00f3 para detectar marcadores de detenci\u00f3n del ciclo celular y apoptosis.\u00a0<\/p>\n<p>El tratamiento de las c\u00e9lulas as\u00edncronas F3II con SUL 15 \u00b5M dio como resultado la detenci\u00f3n del ciclo celular G 2 \/ M, p34 cdc2 elevado(cdc2) actividad quinasa, regulaci\u00f3n por disminuci\u00f3n de Bcl-2, evidencia de activaci\u00f3n de caspasa y agregaci\u00f3n de cromatina nuclear condensada. La posterior exposici\u00f3n de c\u00e9lulas sincronizadas a SUL 15 \u00b5M dio como resultado un n\u00famero elevado de figuras mit\u00f3ticas de profase \/ prometafase, lo que indica la progresi\u00f3n del ciclo celular m\u00e1s all\u00e1 de G 2 y el arresto temprano dentro de la mitosis.\u00a0<\/p>\n<p>Adem\u00e1s, las c\u00e9lulas tratadas con SUL 15 \u00b5M mostraron husos mit\u00f3ticos aberrantes, y dosis m\u00e1s altas de SUL inhibieron la polimerizaci\u00f3n de tubulina in vitro . Adem\u00e1s, los ratones BALB \/ c inyectaron sc con c\u00e9lulas F3II y posteriormente se inyectaron diariamente IV con SUL (15 nmol \/ d\u00eda durante 13 d\u00edas) desarrollaron tumores significativamente m\u00e1s peque\u00f1os (\u223c60% menos en masa) que los controles tratados con veh\u00edculo. El an\u00e1lisis de Western blot de prote\u00ednas tumorales demostr\u00f3 significativamente ( P&lt;0.05) PCNA reducido y fragmentaci\u00f3n de PARP elevada en muestras de animales dosificados con SUL.\u00a0<\/p>\n<p>Tomados en conjunto, estos resultados indican que SUL tiene acciones supresoras del c\u00e1ncer de mama tanto en cultivo celular como en todo el animal. La inhibici\u00f3n de la carcinog\u00e9nesis mamaria parece en parte implicar la perturbaci\u00f3n de los microt\u00fabulos mit\u00f3ticos y el bloqueo temprano de la fase M asociado con la activaci\u00f3n de la cinasa cdc2, lo que indica que las c\u00e9lulas se detienen antes de la salida de la metafase.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jackson, S. J., &amp; Singletary, K. W. (2004).\u00a0Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization.\u00a0Carcinogenesis, 25(2), 219-227. Se ha demostrado que el sulforafano (SUL), un isotiocianato que se encuentra en el br\u00f3coli y otras verduras cruc\u00edferas, induce enzimas de desintoxicaci\u00f3n de fase II, inhibe los tumores mamarios inducidos qu\u00edmicamente en ratas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-39108","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Sulforafano: un inhibidor mit\u00f3tico del carcinoma mamario natural que interrumpe la polimerizaci\u00f3n de la tubulina&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=39108\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Sulforafano: un inhibidor mit\u00f3tico del carcinoma mamario natural que interrumpe la polimerizaci\u00f3n de la tubulina&quot; -\" \/>\n<meta property=\"og:description\" content=\"Jackson, S. 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Se ha demostrado que el sulforafano (SUL), un isotiocianato que se encuentra en el br\u00f3coli y otras verduras cruc\u00edferas, induce enzimas de desintoxicaci\u00f3n de fase II, inhibe los tumores mamarios inducidos qu\u00edmicamente en ratas [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=39108\" \/>\n<meta property=\"article:published_time\" content=\"2020-04-03T03:30:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-Ebd-g1cl3TE\/XoeiX4g4a8I\/AAAAAAAAb4Q\/EAmqLJJ_B70JzdzZyZtTQvowtM1Qua1JgCLcBGAsYHQ\/s320\/Carcinogenesis.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script 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