{"id":39129,"date":"2020-04-04T02:30:32","date_gmt":"2020-04-04T00:30:32","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=39129"},"modified":"2020-04-04T02:30:32","modified_gmt":"2020-04-04T00:30:32","slug":"39129","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=39129","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEfectos de la quercetina sobre las reacciones redox dependientes de hemoglobina: relaci\u00f3n con la lesi\u00f3n hep\u00e1tica de rata por sobrecarga de hierro\u00bb"},"content":{"rendered":"

<\/a>Lu, N. H., Chen, C., He, Y. J., Tian, R., Xiao, Q., & Peng, Y. Y. (2013).\u00a0Effects of quercetin on hemoglobin-dependent redox reactions: relationship to iron-overload rat liver injury<\/a>.\u00a0Journal of Asian natural products research,<\/i>\u00a015(12), 1265-1276.<\/p>\n

Se ha informado ampliamente que los flavonoides protegen el da\u00f1o hep\u00e1tico en las enfermedades por sobrecarga de hierro, donde el mecanismo de esta acci\u00f3n terap\u00e9utica depende de sus efectos antioxidantes, incluidos la eliminaci\u00f3n de radicales libres y la quelaci\u00f3n de metales.\u00a0<\/p>\n

En este estudio, en contraste con la disminuci\u00f3n significativa en el contenido de hierro, la quercetina (Qu) de una dieta m\u00e1s baja (0.3%, p \/ p) mostr\u00f3 una capacidad prooxidante en la formaci\u00f3n de prote\u00ednas carbonilo y exhibi\u00f3 un efecto no obvio en la lesi\u00f3n hep\u00e1tica de ratas con sobrecarga de hierro.\u00a0<\/p>\n

Adem\u00e1s, se investigaron las actividades antioxidantes y prooxidantes de Qu en las reacciones redox dependientes de la hemoglobina (Hb) (es decir, la estabilidad oxidativa de la Hb y su oxidaci\u00f3n proteica inducida por Hb intermediaria citot\u00f3xica), para ilustrar la oxidaci\u00f3n proteica elevada en niveles m\u00e1s bajos Rata de sobrecarga de hierro tratada con Qu. Se encontr\u00f3 que se gener\u00f3 super\u00f3xido (O\u2082 \u00b7 \u207b) y per\u00f3xido de hidr\u00f3geno (H\u2082O\u2082) durante la reacci\u00f3n entre Qu y Hb. Qu, sin embargo, redujo efectivamente el intermedio de ferryl de nuevo a Hb f\u00e9rrica en una reacci\u00f3n cin\u00e9tica bif\u00e1sica.\u00a0<\/p>\n

Adem\u00e1s, Qu podr\u00eda agravar significativamente la oxidaci\u00f3n de prote\u00ednas inducida por Hb-H\u2082O\u2082 a bajas concentraciones y exhibir efectos protectores a altas concentraciones. A diferencia de los mecanismos antioxidantes cl\u00e1sicos de Qu, los efectos duales sobre las reacciones redox de Hb in vitro, por lo tanto, pueden proporcionar nuevas ideas sobre las implicaciones fisiol\u00f3gicas y farmacol\u00f3gicas de Qu con la enfermedad por sobrecarga de hierro.\u00a0<\/p>\n

Qu podr\u00eda agravar significativamente la oxidaci\u00f3n de prote\u00ednas inducida por Hb-H\u2082O\u2082 a bajas concentraciones y exhibir efectos protectores a altas concentraciones.<\/p>\n","protected":false},"excerpt":{"rendered":"

Lu, N. H., Chen, C., He, Y. J., Tian, R., Xiao, Q., & Peng, Y. Y. (2013).\u00a0Effects of quercetin on hemoglobin-dependent redox reactions: relationship to iron-overload rat liver injury.\u00a0Journal of Asian natural products research,\u00a015(12), 1265-1276. Se ha informado ampliamente que los flavonoides protegen el da\u00f1o hep\u00e1tico en las enfermedades por sobrecarga de hierro, donde el […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-39129","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"\n\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: "Efectos de la quercetina sobre las reacciones redox dependientes de hemoglobina: relaci\u00f3n con la lesi\u00f3n hep\u00e1tica de rata por sobrecarga de hierro" -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=39129\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: "Efectos de la quercetina sobre las reacciones redox dependientes de hemoglobina: relaci\u00f3n con la lesi\u00f3n hep\u00e1tica de rata por sobrecarga de hierro" -\" \/>\n<meta property=\"og:description\" content=\"Lu, N. H., Chen, C., He, Y. J., Tian, R., Xiao, Q., & Peng, Y. Y. (2013).\u00a0Effects of quercetin on hemoglobin-dependent redox reactions: relationship to iron-overload rat liver injury.\u00a0Journal of Asian natural products research,\u00a015(12), 1265-1276. Se ha informado ampliamente que los flavonoides protegen el da\u00f1o hep\u00e1tico en las enfermedades por sobrecarga de hierro, donde el […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=39129\" \/>\n<meta property=\"article:published_time\" content=\"2020-04-04T00:30:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-dmvskyd9NRs\/Xojf-Qk4DGI\/AAAAAAAAb5Q\/VAiVC2xFHE0jYPWkWG8bXcVLXQ050aDegCLcBGAsYHQ\/s320\/Journal_Asian%2BNatural%2BProducts%2BResearch.JPG\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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