{"id":39138,"date":"2020-04-04T05:30:01","date_gmt":"2020-04-04T03:30:01","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=39138"},"modified":"2020-04-04T05:30:01","modified_gmt":"2020-04-04T03:30:01","slug":"39138","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=39138","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa lute\u00edna mejora la defensa antioxidante in vivo y protege contra el da\u00f1o del ADN y la inestabilidad cromos\u00f3mica inducida por el cisplatino\u00bb"},"content":{"rendered":"

<\/a>Serpeloni, J. M., Grotto, D., Mercadante, A. Z., Bianchi, M. D. L. P., & Antunes, L. M. G. (2010).\u00a0Lutein improves antioxidant defense in vivo and protects against DNAdamage and chromosome instability induced by cisplatin<\/a>.\u00a0Archives of toxicology<\/i>, 84(10), 811-822.<\/p>\n

La lute\u00edna (LT) es el segundo carotenoide m\u00e1s prevalente en el suero humano, y est\u00e1 abundantemente presente en los vegetales de hojas verdes oscuras.\u00a0<\/p>\n

OBJETIVOS: Los objetivos de este estudio fueron evaluar la genotoxicidad y mutagenicidad de la LT, y sus efectos protectores in vivo contra el da\u00f1o del ADN y la inestabilidad cromos\u00f3mica inducida por el cisplatino (cDDP).\u00a0<\/p>\n

METODO: Para ello se utiliz\u00f3 el ensayo del cometa y la prueba de micron\u00facleos (MN), y se evaluaron los efectos antioxidantes de la LT mediante la determinaci\u00f3n de la actividad enzim\u00e1tica (catalasa-CAT) y no enzim\u00e1tica (glutati\u00f3n-GSH reducido). Los ratones se dividieron en seis grupos: cDDP, aceite mineral (OM), grupos de LT y grupos de LT + cDDP. Para realizar la prueba de MN en las c\u00e9lulas de sangre perif\u00e9rica (PB), se recogieron muestras de sangre antes del primer tratamiento (T0), y 36 h (T1) y 14 d\u00edas (T2) despu\u00e9s del primer tratamiento. Para realizar el ensayo cometa, se recogieron muestras de sangre 4 h despu\u00e9s del primer y \u00faltimo tratamiento. Se analiz\u00f3 la capacidad oxidativa en la sangre total que se recogi\u00f3 24 h despu\u00e9s del \u00faltimo tratamiento, cuando tambi\u00e9n se recogi\u00f3 una muestra de m\u00e9dula \u00f3sea (BM) para la prueba de MN.\u00a0<\/p>\n

RESULTADOS: No se observaron efectos genot\u00f3xicos o mutag\u00e9nicos de la LT en las dosis evaluadas. Encontramos que este carotenoide fue capaz de reducir la formaci\u00f3n de enlaces cruzados y la inestabilidad cromos\u00f3mica inducida por el cDDP. No se observaron diferencias en los niveles de CAT, y el tratamiento de LT aument\u00f3 los niveles de GSH en comparaci\u00f3n con un grupo de control negativo, reforzando el papel de este carotenoide como antioxidante.<\/p>\n","protected":false},"excerpt":{"rendered":"

Serpeloni, J. M., Grotto, D., Mercadante, A. Z., Bianchi, M. D. L. P., & Antunes, L. M. G. (2010).\u00a0Lutein improves antioxidant defense in vivo and protects against DNAdamage and chromosome instability induced by cisplatin.\u00a0Archives of toxicology, 84(10), 811-822. La lute\u00edna (LT) es el segundo carotenoide m\u00e1s prevalente en el suero humano, y est\u00e1 abundantemente presente […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-39138","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"\n\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: "La lute\u00edna mejora la defensa antioxidante in vivo y protege contra el da\u00f1o del ADN y la inestabilidad cromos\u00f3mica inducida por el cisplatino" -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=39138\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: "La lute\u00edna mejora la defensa antioxidante in vivo y protege contra el da\u00f1o del ADN y la inestabilidad cromos\u00f3mica inducida por el cisplatino" -\" \/>\n<meta property=\"og:description\" content=\"Serpeloni, J. M., Grotto, D., Mercadante, A. Z., Bianchi, M. D. L. P., & Antunes, L. M. G. (2010).\u00a0Lutein improves antioxidant defense in vivo and protects against DNAdamage and chromosome instability induced by cisplatin.\u00a0Archives of toxicology, 84(10), 811-822. 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