{"id":39141,"date":"2020-04-04T06:30:50","date_gmt":"2020-04-04T04:30:50","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=39141"},"modified":"2020-04-04T06:30:50","modified_gmt":"2020-04-04T04:30:50","slug":"39141","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=39141","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa lute\u00edna carotenoide en la dieta protege contra el da\u00f1o del ADN y las alteraciones del estado redox inducido por cisplatino en c\u00e9lulas HepG2 derivadas de humanos\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-UsS2uJY4gE8\/XojzGdxgyRI\/AAAAAAAAb5w\/QR031HgayRUjzO8ajJ85743n9jnUsXv9gCLcBGAsYHQ\/s1600\/Toxicology_Vitro.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-UsS2uJY4gE8\/XojzGdxgyRI\/AAAAAAAAb5w\/QR031HgayRUjzO8ajJ85743n9jnUsXv9gCLcBGAsYHQ\/s1600\/Toxicology_Vitro.jpg\" border=\"0\" data-original-width=\"198\" data-original-height=\"264\" \/><\/a>Serpeloni, J. M., Barcelos, G. R. M., Angeli, J. P. F., Mercadante, A. Z., Bianchi, M. L. P., &amp; Antunes, L. M. G. (2012).\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0887233311003110\">Dietary carotenoid lutein protects against DNA damage and alterations of the redox status induced by cisplatin in human derived HepG2 cells<\/a>.\u00a0<i>Toxicology in Vitro<\/i>, 26(2), 288-294.<\/p>\n<p>FONDO: Varios estudios epidemiol\u00f3gicos y experimentales han informado que la lute\u00edna (LT) presenta propiedades antioxidantes.\u00a0<\/p>\n<p>OBJETIVO: El objetivo del presente estudio fue investigar los efectos protectores de la LT contra el estr\u00e9s oxidativo y el da\u00f1o al ADN inducido por cisplatino (cDDP) en una l\u00ednea celular de h\u00edgado derivado de humanos (HepG2).\u00a0<\/p>\n<p>M\u00c9TODO: La viabilidad celular y el da\u00f1o en el ADN se controlaron mediante ensayos MTT y cometas. Adem\u00e1s, tambi\u00e9n se evaluaron diferentes par\u00e1metros bioqu\u00edmicos relacionados con el estado redox (glutati\u00f3n, citocromo-c y ROS intracelular).\u00a0<\/p>\n<p>RESULTADOS: Se observ\u00f3 un claro da\u00f1o en el ADN con el tratamiento con cDDP (1,0 \u03bcM). En combinaci\u00f3n con el carotenoide, se observ\u00f3 una reducci\u00f3n del da\u00f1o en el ADN despu\u00e9s del tratamiento previo y simult\u00e1neo de las c\u00e9lulas, pero no cuando se a\u00f1adi\u00f3 el carotenoide a las c\u00e9lulas despu\u00e9s de la exposici\u00f3n al cDDP. La exposici\u00f3n de las c\u00e9lulas a cDDP tambi\u00e9n caus\u00f3 cambios significativos de todos los par\u00e1metros bioqu\u00edmicos y en el tratamiento conjunto de las c\u00e9lulas con LT, el carotenoide revirti\u00f3 estas alteraciones.\u00a0<\/p>\n<p>CONCLUSI\u00d3N: Los resultados indican que el cDDP induce un estr\u00e9s oxidativo pronunciado en las c\u00e9lulas HepG2 que est\u00e1 relacionado con el da\u00f1o del ADN y que la suplementaci\u00f3n con el antioxidante LT puede proteger estos efectos adversos causados \u200b\u200bpor la exposici\u00f3n de las c\u00e9lulas al compuesto de platino, que puede ser un buen pron\u00f3stico para la quimioprevenci\u00f3n.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Serpeloni, J. M., Barcelos, G. R. M., Angeli, J. P. F., Mercadante, A. Z., Bianchi, M. L. P., &amp; Antunes, L. M. G. (2012).\u00a0Dietary carotenoid lutein protects against DNA damage and alterations of the redox status induced by cisplatin in human derived HepG2 cells.\u00a0Toxicology in Vitro, 26(2), 288-294. FONDO: Varios estudios epidemiol\u00f3gicos y experimentales han [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-39141","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La lute\u00edna carotenoide en la dieta protege contra el da\u00f1o del ADN y las alteraciones del estado redox inducido por cisplatino en c\u00e9lulas HepG2 derivadas de humanos&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=39141\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La lute\u00edna carotenoide en la dieta protege contra el da\u00f1o del ADN y las alteraciones del estado redox inducido por cisplatino en c\u00e9lulas HepG2 derivadas de humanos&quot; -\" \/>\n<meta property=\"og:description\" content=\"Serpeloni, J. M., Barcelos, G. R. M., Angeli, J. P. F., Mercadante, A. Z., Bianchi, M. L. P., &amp; Antunes, L. M. G. (2012).\u00a0Dietary carotenoid lutein protects against DNA damage and alterations of the redox status induced by cisplatin in human derived HepG2 cells.\u00a0Toxicology in Vitro, 26(2), 288-294. 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