{"id":39501,"date":"2020-04-13T03:30:04","date_gmt":"2020-04-13T01:30:04","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=39501"},"modified":"2020-04-13T03:30:04","modified_gmt":"2020-04-13T01:30:04","slug":"39501","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=39501","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEfecto del inhibidor de la tirosina quinasa, la geniste\u00edna, sobre la producci\u00f3n de PGE 2 estimulada por interleucina-1 en c\u00e9lulas mesangiales\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-3OJX33ZQ5Sg\/XpTVWXah1TI\/AAAAAAAAcFQ\/T6lLeN615Z0wX89HdZUeyIW4Ehv2Fbk2wCLcBGAsYHQ\/s1600\/Biochemical_Biophysical_Research_Comunication.gif\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-3OJX33ZQ5Sg\/XpTVWXah1TI\/AAAAAAAAcFQ\/T6lLeN615Z0wX89HdZUeyIW4Ehv2Fbk2wCLcBGAsYHQ\/s1600\/Biochemical_Biophysical_Research_Comunication.gif\" border=\"0\" data-original-width=\"220\" data-original-height=\"295\" \/><\/a>Coyne, D. W., &amp; Morrison, A. R. (1990).\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006291X05800944\">Effect of the tyrosine kinase inhibitor, genistein, on interleukin-1 stimulated PGE2 production in mesangial cells<\/a>.\u00a0<i>Biochemical and biophysical research communications<\/i>, 173(2), 718-724.\u00a0<\/p>\n<p>La producci\u00f3n de prostaglandinas y la formaci\u00f3n de AMPc son dos v\u00edas de se\u00f1alizaci\u00f3n identificadas para IL-1, aunque ninguna explica adecuadamente la multitud de efectos de IL-1.\u00a0<\/p>\n<p>Para investigar el papel de la fosforilaci\u00f3n de la tirosina en la se\u00f1alizaci\u00f3n de IL-1, utilizamos el inhibidor de la tirosina quinasa, la geniste\u00edna. A 10-30 \u03bcg \/ ml, la geniste\u00edna bloque\u00f3 la producci\u00f3n de prostaglandina estimulada por IL-1 y la inducci\u00f3n de la prostaglandina endoper\u00f3xido sintasa (PES) en c\u00e9lulas mesangiales glomerulares mantenidas en suero al 10%. La adici\u00f3n de horas de geniste\u00edna despu\u00e9s de IL-1 adem\u00e1s tambi\u00e9n se detuvo m\u00e1s PGE 2 s\u00edntesis. La geniste\u00edna no pudo bloquear la actividad de PES in vitro, lo que indica que no estaba actuando como un inhibidor de PES.\u00a0<\/p>\n<p>En general, estos datos sugieren que la fosforilaci\u00f3n de tirosina puede ser un evento requerido para la estimulaci\u00f3n de IL-1 de PGE 2 y actividad de PSA, ya sea directamente como parte de la se\u00f1alizaci\u00f3n de IL-1, o indirectamente como parte de un efecto de competencia suero \/ PDGF en c\u00e9lulas mesangiales.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Coyne, D. W., &amp; Morrison, A. R. (1990).\u00a0Effect of the tyrosine kinase inhibitor, genistein, on interleukin-1 stimulated PGE2 production in mesangial cells.\u00a0Biochemical and biophysical research communications, 173(2), 718-724.\u00a0 La producci\u00f3n de prostaglandinas y la formaci\u00f3n de AMPc son dos v\u00edas de se\u00f1alizaci\u00f3n identificadas para IL-1, aunque ninguna explica adecuadamente la multitud de efectos de IL-1.\u00a0 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-39501","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Efecto del inhibidor de la tirosina quinasa, la geniste\u00edna, sobre la producci\u00f3n de PGE 2 estimulada por interleucina-1 en c\u00e9lulas mesangiales&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=39501\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Efecto del inhibidor de la tirosina quinasa, la geniste\u00edna, sobre la producci\u00f3n de PGE 2 estimulada por interleucina-1 en c\u00e9lulas mesangiales&quot; -\" \/>\n<meta property=\"og:description\" content=\"Coyne, D. 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