{"id":39725,"date":"2020-04-18T01:30:10","date_gmt":"2020-04-17T23:30:10","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=39725"},"modified":"2020-04-18T01:30:10","modified_gmt":"2020-04-17T23:30:10","slug":"39725","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=39725","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa inhibici\u00f3n de la dipeptidil peptidasa IV (DPP IV) es uno de los mecanismos que explican el efecto hipogluc\u00e9mico de la berberina\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-RWub_gX5tGM\/Xps2A6EsM4I\/AAAAAAAAcRI\/WBjN5wui5hkIg5-6zJOjQ8mpUbAMmHUrQCLcBGAsYHQ\/s1600\/Journal_Enzyme%2BInhibition%2Band%2BMedicinal%2BChemistry.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-RWub_gX5tGM\/Xps2A6EsM4I\/AAAAAAAAcRI\/WBjN5wui5hkIg5-6zJOjQ8mpUbAMmHUrQCLcBGAsYHQ\/s320\/Journal_Enzyme%2BInhibition%2Band%2BMedicinal%2BChemistry.jpg\" width=\"246\" height=\"320\" border=\"0\" data-original-width=\"277\" data-original-height=\"360\" \/><\/a>Al-masri, I. M., Mohammad, M. K., &amp; Tahaa, M. O. (2009). Inhibition of dipeptidyl peptidase IV (DPP IV)\u00a0<a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14756360802610761\">is one of the mechanisms explaining the hypoglycemic effect of berberine<\/a>.\u00a0<i>Journal of enzyme inhibition and medicinal chemistry<\/i>, 24(5), 1061-1066.Baek,<\/p>\n<p>La berberina se investig\u00f3 como un inhibidor de la dipeptidil peptidasa IV humana (DPP IV) en un intento de explicar sus actividades anti-hipergluc\u00e9micas.\u00a0<\/p>\n<p>La investigaci\u00f3n incluy\u00f3 experimentos de acoplamiento simulados para ajustar la berberina dentro del bolsillo de uni\u00f3n de DPP IV.\u00a0<\/p>\n<p>Se descubri\u00f3 que la berberina encaja f\u00e1cilmente dentro del bolsillo de uni\u00f3n de DPP IV en una orientaci\u00f3n de baja energ\u00eda caracterizada por interacciones electrost\u00e1ticas atractivas \u00f3ptimas que unen el \u00e1tomo de nitr\u00f3geno con carga positiva de isoquinolinio (berberina) y el residuo \u00e1cido cargado negativamente de \u00e1cido glut\u00e1mico-205 (GLU205) de DPP IV.\u00a0<\/p>\n<p>Experimentalmente, se descubri\u00f3 que la berberina inhibe la DPP IV recombinante humana in vitro con IC 50= 13,3 \u03bcM. Nuestros hallazgos sugieren que la inhibici\u00f3n de DPP IV es, al menos, uno de los mecanismos que explican la actividad anti-hipergluc\u00e9mica de la berberina.\u00a0<\/p>\n<p>El hecho de que recientemente se inform\u00f3 que la berberina inhibe de manera potente la prote\u00edna diana pro-diab\u00e9tica humana tirosina fosfatasa 1B (h-PTP 1B) revela un nuevo inhibidor dual dual h-PTP 1B \/ DPP IV.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Al-masri, I. M., Mohammad, M. K., &amp; Tahaa, M. O. (2009). Inhibition of dipeptidyl peptidase IV (DPP IV)\u00a0is one of the mechanisms explaining the hypoglycemic effect of berberine.\u00a0Journal of enzyme inhibition and medicinal chemistry, 24(5), 1061-1066.Baek, La berberina se investig\u00f3 como un inhibidor de la dipeptidil peptidasa IV humana (DPP IV) en un intento de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-39725","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La inhibici\u00f3n de la dipeptidil peptidasa IV (DPP IV) es uno de los mecanismos que explican el efecto hipogluc\u00e9mico de la berberina&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=39725\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La inhibici\u00f3n de la dipeptidil peptidasa IV (DPP IV) es uno de los mecanismos que explican el efecto hipogluc\u00e9mico de la berberina&quot; -\" \/>\n<meta property=\"og:description\" content=\"Al-masri, I. M., Mohammad, M. K., &amp; Tahaa, M. O. (2009). Inhibition of dipeptidyl peptidase IV (DPP IV)\u00a0is one of the mechanisms explaining the hypoglycemic effect of berberine.\u00a0Journal of enzyme inhibition and medicinal chemistry, 24(5), 1061-1066.Baek, La berberina se investig\u00f3 como un inhibidor de la dipeptidil peptidasa IV humana (DPP IV) en un intento de [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=39725\" \/>\n<meta property=\"article:published_time\" content=\"2020-04-17T23:30:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-RWub_gX5tGM\/Xps2A6EsM4I\/AAAAAAAAcRI\/WBjN5wui5hkIg5-6zJOjQ8mpUbAMmHUrQCLcBGAsYHQ\/s320\/Journal_Enzyme%2BInhibition%2Band%2BMedicinal%2BChemistry.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=39725#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=39725\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa inhibici\u00f3n de la dipeptidil peptidasa IV (DPP IV) es uno de los mecanismos que explican el efecto hipogluc\u00e9mico de la berberina\u00bb\",\"datePublished\":\"2020-04-17T23:30:10+00:00\",\"dateModified\":\"2020-04-17T23:30:10+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=39725\"},\"wordCount\":252,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"articleSection\":[\"Sustancias Bioactivas\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=39725#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=39725\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?p=39725\",\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \\\"La inhibici\u00f3n de la dipeptidil peptidasa IV (DPP IV) es uno de los mecanismos que explican el efecto hipogluc\u00e9mico de la berberina\\\" -\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\"},\"datePublished\":\"2020-04-17T23:30:10+00:00\",\"dateModified\":\"2020-04-17T23:30:10+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=39725#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=39725\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=39725#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/rina.naturopatiadigital.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa inhibici\u00f3n de la dipeptidil peptidasa IV (DPP IV) es uno de los mecanismos que explican el efecto hipogluc\u00e9mico de la berberina\u00bb\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"name\":\"\",\"description\":\"Red Investigaci\u00f3n Naturop\u00e1tica\",\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\",\"name\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"contentUrl\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"width\":960,\"height\":960,\"caption\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\"},\"image\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/rina.naturopatiadigital.eu\"],\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La inhibici\u00f3n de la dipeptidil peptidasa IV (DPP IV) es uno de los mecanismos que explican el efecto hipogluc\u00e9mico de la berberina\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=39725","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La inhibici\u00f3n de la dipeptidil peptidasa IV (DPP IV) es uno de los mecanismos que explican el efecto hipogluc\u00e9mico de la berberina\" -","og_description":"Al-masri, I. M., Mohammad, M. K., &amp; Tahaa, M. O. (2009). Inhibition of dipeptidyl peptidase IV (DPP IV)\u00a0is one of the mechanisms explaining the hypoglycemic effect of berberine.\u00a0Journal of enzyme inhibition and medicinal chemistry, 24(5), 1061-1066.Baek, La berberina se investig\u00f3 como un inhibidor de la dipeptidil peptidasa IV humana (DPP IV) en un intento de [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=39725","article_published_time":"2020-04-17T23:30:10+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/-RWub_gX5tGM\/Xps2A6EsM4I\/AAAAAAAAcRI\/WBjN5wui5hkIg5-6zJOjQ8mpUbAMmHUrQCLcBGAsYHQ\/s320\/Journal_Enzyme%2BInhibition%2Band%2BMedicinal%2BChemistry.jpg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"1 minuto"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=39725#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=39725"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa inhibici\u00f3n de la dipeptidil peptidasa IV (DPP IV) es uno de los mecanismos que explican el efecto hipogluc\u00e9mico de la berberina\u00bb","datePublished":"2020-04-17T23:30:10+00:00","dateModified":"2020-04-17T23:30:10+00:00","mainEntityOfPage":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=39725"},"wordCount":252,"commentCount":0,"publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"articleSection":["Sustancias Bioactivas"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rina.naturopatiadigital.eu\/?p=39725#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=39725","url":"https:\/\/rina.naturopatiadigital.eu\/?p=39725","name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La inhibici\u00f3n de la dipeptidil peptidasa IV (DPP IV) es uno de los mecanismos que explican el efecto hipogluc\u00e9mico de la berberina\" -","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#website"},"datePublished":"2020-04-17T23:30:10+00:00","dateModified":"2020-04-17T23:30:10+00:00","breadcrumb":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=39725#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rina.naturopatiadigital.eu\/?p=39725"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=39725#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/rina.naturopatiadigital.eu\/"},{"@type":"ListItem","position":2,"name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa inhibici\u00f3n de la dipeptidil peptidasa IV (DPP IV) es uno de los mecanismos que explican el efecto hipogluc\u00e9mico de la berberina\u00bb"}]},{"@type":"WebSite","@id":"https:\/\/rina.naturopatiadigital.eu\/#website","url":"https:\/\/rina.naturopatiadigital.eu\/","name":"","description":"Red Investigaci\u00f3n Naturop\u00e1tica","publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/rina.naturopatiadigital.eu\/#organization","name":"Organizaci\u00f3n Colegial Naturop\u00e1tica","url":"https:\/\/rina.naturopatiadigital.eu\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/","url":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","contentUrl":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","width":960,"height":960,"caption":"Organizaci\u00f3n Colegial Naturop\u00e1tica"},"image":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7","name":"admin","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/rina.naturopatiadigital.eu"],"url":"https:\/\/rina.naturopatiadigital.eu\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/39725","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=39725"}],"version-history":[{"count":0,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/39725\/revisions"}],"wp:attachment":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=39725"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=39725"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=39725"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}