{"id":39793,"date":"2020-04-20T06:30:39","date_gmt":"2020-04-20T04:30:39","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=39793"},"modified":"2020-04-20T06:30:39","modified_gmt":"2020-04-20T04:30:39","slug":"39793","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=39793","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abEl metabolismo de los l\u00edpidos aberrantes interrumpe la homeostasis del calcio causando estr\u00e9s del ret\u00edculo endopl\u00e1smico hep\u00e1tico en la obesidad\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-4z8GRzBDV-Q\/Xpy79dIw6zI\/AAAAAAAAcTU\/y82rLV9VP1QO_6dOAbE9JCXWGdJ5LLQNQCLcBGAsYHQ\/s1600\/Nature.jpg\" data-blogger-escaped-style=\"clear: left; float: left; margin-bottom: 1em; margin-right: 1em;\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-4z8GRzBDV-Q\/Xpy79dIw6zI\/AAAAAAAAcTU\/y82rLV9VP1QO_6dOAbE9JCXWGdJ5LLQNQCLcBGAsYHQ\/s320\/Nature.jpg\" width=\"241\" height=\"320\" border=\"0\" data-blogger-escaped-data-original-height=\"451\" data-blogger-escaped-data-original-width=\"340\" \/><\/a>Fu, S., Yang, L., Li, P., Hofmann, O., Dicker, L., Hide, W., &#8230; &amp; Hotamisligil, G. S. (2011). A<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3102791\/\">berrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity<\/a>.\u00a0<i>Nature<\/i>, 473(7348), 528-531.<\/p>\n<p>El ret\u00edculo endopl\u00e1smico (ER) es el sitio principal de s\u00edntesis de prote\u00ednas y l\u00edpidos, biog\u00e9nesis de membrana, desintoxicaci\u00f3n xenobi\u00f3tica y almacenamiento de calcio celular, y la perturbaci\u00f3n de la homeostasis de ER provoca estr\u00e9s y la activaci\u00f3n de la respuesta de prote\u00edna desplegada.<\/p>\n<p>Se ha demostrado que la activaci\u00f3n cr\u00f3nica del estr\u00e9s ER tiene un papel importante en el desarrollo de resistencia a la insulina y diabetes en la obesidad. Sin embargo, no se entienden los mecanismos que conducen al estr\u00e9s cr\u00f3nico de ER en un contexto metab\u00f3lico en general, y en la obesidad en particular.<\/p>\n<p>Aqu\u00ed examinamos comparativamente el paisaje prote\u00f3mico y lipid\u00f3mico de la ER hep\u00e1tica purificada de ratones delgados y obesos para explorar los mecanismos del estr\u00e9s cr\u00f3nico de ER en la obesidad. Encontramos supresi\u00f3n de prote\u00ednas pero estimulaci\u00f3n de la s\u00edntesis de l\u00edpidos en el ER obeso sin alteraciones significativas en el contenido de chaperonas.<\/p>\n<p>Las alteraciones en la composici\u00f3n de \u00e1cidos grasos y l\u00edpidos ER provocan la inhibici\u00f3n de la actividad de la ATPasa de calcio del ret\u00edculo sarco \/ endopl\u00e1smico (SERCA) y el estr\u00e9s ER. Correcci\u00f3n de la alteraci\u00f3n inducida por la obesidad de la composici\u00f3n de fosfol\u00edpidos ER o la sobreexpresi\u00f3n hep\u00e1tica de Serca in vivoambos redujeron el estr\u00e9s cr\u00f3nico por ER y mejoraron la homeostasis de la glucosa.<\/p>\n<p>Por lo tanto, establecimos que el metabolismo anormal de los l\u00edpidos y el calcio son importantes contribuyentes al estr\u00e9s hep\u00e1tico ER en la obesidad.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fu, S., Yang, L., Li, P., Hofmann, O., Dicker, L., Hide, W., &#8230; &amp; Hotamisligil, G. S. (2011). Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity.\u00a0Nature, 473(7348), 528-531. El ret\u00edculo endopl\u00e1smico (ER) es el sitio principal de s\u00edntesis de prote\u00ednas y l\u00edpidos, biog\u00e9nesis de membrana, desintoxicaci\u00f3n xenobi\u00f3tica y almacenamiento de [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-39793","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;El metabolismo de los l\u00edpidos aberrantes interrumpe la homeostasis del calcio causando estr\u00e9s del ret\u00edculo endopl\u00e1smico hep\u00e1tico en la obesidad&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=39793\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;El metabolismo de los l\u00edpidos aberrantes interrumpe la homeostasis del calcio causando estr\u00e9s del ret\u00edculo endopl\u00e1smico hep\u00e1tico en la obesidad&quot; -\" \/>\n<meta property=\"og:description\" content=\"Fu, S., Yang, L., Li, P., Hofmann, O., Dicker, L., Hide, W., &#8230; &amp; Hotamisligil, G. 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El ret\u00edculo endopl\u00e1smico (ER) es el sitio principal de s\u00edntesis de prote\u00ednas y l\u00edpidos, biog\u00e9nesis de membrana, desintoxicaci\u00f3n xenobi\u00f3tica y almacenamiento de [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=39793\" \/>\n<meta property=\"article:published_time\" content=\"2020-04-20T04:30:39+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-4z8GRzBDV-Q\/Xpy79dIw6zI\/AAAAAAAAcTU\/y82rLV9VP1QO_6dOAbE9JCXWGdJ5LLQNQCLcBGAsYHQ\/s320\/Nature.jpg\" \/>\n<meta name=\"author\" content=\"admin2\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin2\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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