{"id":40297,"date":"2020-05-01T00:30:22","date_gmt":"2020-04-30T22:30:22","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=40297"},"modified":"2020-05-01T00:30:22","modified_gmt":"2020-04-30T22:30:22","slug":"40297","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=40297","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: Efectos inhibitorios diferenciales de varios flavonoides en las actividades de la transcriptasa inversa y las polimerasas de ADN y ARN celular\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-X6dgdDoSqLE\/Xq27Aci2azI\/AAAAAAAAcjM\/leaOpQx9-BM9XGrj4HV5lZ0J7sUA1ZFRwCLcBGAsYHQ\/s1600\/European_Journal_Biochemistry.gif\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-X6dgdDoSqLE\/Xq27Aci2azI\/AAAAAAAAcjM\/leaOpQx9-BM9XGrj4HV5lZ0J7sUA1ZFRwCLcBGAsYHQ\/s1600\/European_Journal_Biochemistry.gif\" border=\"0\" data-original-width=\"95\" data-original-height=\"125\" \/><\/a>Ono, K., Nakane, H., Fukushima, M., Chermann, J. C., &amp; Barr\u00e9\u2010Sinoussi, F. (1990).\u00a0<a href=\"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1432-1033.1990.tb15597.x\">Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases<\/a>.\u00a0<i>European Journal of Biochemistry<\/i>, 190(3), 469-476.<\/p>\n<p>Cuatro flavonoides, 5,6,7-trihidroxiflavona (baicale\u00edna), 3,3 &#8216;, 4&#8217;, 5,7-pentahidroxiflavona (quercetina), 3,3 &#8216;, 4&#8217;, 5,6,7-hexahidroxiflavona (quercetagetina) y se encontr\u00f3 que 3,3 &#8216;, 4&#8217;, 5,5 &#8216;, 7-hexahidroxiflavona (miricetina) son inhibidores potentes de las transcriptasas inversas del virus de la leucemia murina Rauscher (RLV) y el virus de la inmunodeficiencia humana (VIH).\u00a0<\/p>\n<p>En las condiciones de reacci\u00f3n empleadas, cualquiera de estos flavonoides inhibi\u00f3 casi por completo la actividad de la transcriptasa inversa RLV a una concentraci\u00f3n de 1 microgramo \/ ml. La transcriptasa inversa del VIH se inhibi\u00f3 en un 100%, 100%, 90% y 70% en presencia de 2 microgramos \/ ml de quercetina, miricetina, quercetagetina y baicale\u00edna, respectivamente.\u00a0<\/p>\n<p>El modo de inhibici\u00f3n de estos flavonoides fue competitivo (transcriptasa inversa RLV) o parcialmente competitivo (transcriptasa inversa VIH) con respecto al complejo template.primer, (rA) n. (DT), y no competitivo con respecto al sustrato trifosfato, dTTP .\u00a0<\/p>\n<p>Los valores de Ki para la transcriptasa inversa RLV fueron 0.37 microM y 0.08 microM para baicale\u00edna y quercetina, respectivamente, y los de la transcriptasa inversa para VIH fueron 2.52 microM, 0.52 microM, 0.46 microM y 0.08 microM para baicale\u00edna, quercetina, quercetagetina y miricetina, respectivamente.\u00a0<\/p>\n<p>Estudios comparativos con otros flavonoides (hidroxiflavonas, dihidroxiflavonas y polihidroxiflavonas y flavanonas) llevados a cabo para aclarar las relaciones estructura \/ actividad. revel\u00f3 que la presencia del doble enlace insaturado entre las posiciones 2 y 3 del anillo de pirona flavonoide y los tres grupos hidroxilo introducidos en las posiciones 5, 6 y 7 (es decir, baicale\u00edna) eran un requisito previo para la inhibici\u00f3n de la actividad de la transcriptasa inversa. La eliminaci\u00f3n del grupo 6-hidroxilo de baicale\u00edna requiri\u00f3 la introducci\u00f3n de tres grupos hidroxilo adicionales en las posiciones 3, 3 &#8216;y 4&#8217; (quercetina), para proporcionar un compuesto todav\u00eda capaz de inhibir la actividad de la transcriptasa inversa. La quercetagetina que contiene las estructuras de baicale\u00edna y quercetina, y la miricetina que tiene la estructura de quercetina con un grupo hidroxilo adicional en la posici\u00f3n 5 &#8216;tambi\u00e9n demostraron ser fuertes inhibidores de la actividad de la transcriptasa inversa.<\/p>\n<p>La inhibici\u00f3n por baicale\u00edna de la transcriptasa inversa es altamente espec\u00edfica, mientras que la quercetina y la quercetagetina tambi\u00e9n fueron inhibidores fuertes de la ADN polimerasa beta y la ADN polimerasa I, respectivamente. La miricetina tambi\u00e9n fue un potente inhibidor tanto de la ADN polimerasa alfa como de la ADN polimerasa I.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ono, K., Nakane, H., Fukushima, M., Chermann, J. C., &amp; Barr\u00e9\u2010Sinoussi, F. (1990).\u00a0Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases.\u00a0European Journal of Biochemistry, 190(3), 469-476. Cuatro flavonoides, 5,6,7-trihidroxiflavona (baicale\u00edna), 3,3 &#8216;, 4&#8217;, 5,7-pentahidroxiflavona (quercetina), 3,3 &#8216;, 4&#8217;, 5,6,7-hexahidroxiflavona (quercetagetina) y se encontr\u00f3 que 3,3 &#8216;, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-40297","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: Efectos inhibitorios diferenciales de varios flavonoides en las actividades de la transcriptasa inversa y las polimerasas de ADN y ARN celular&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=40297\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: Efectos inhibitorios diferenciales de varios flavonoides en las actividades de la transcriptasa inversa y las polimerasas de ADN y ARN celular&quot; -\" \/>\n<meta property=\"og:description\" content=\"Ono, K., Nakane, H., Fukushima, M., Chermann, J. 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