{"id":40794,"date":"2020-05-13T04:30:08","date_gmt":"2020-05-13T02:30:08","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=40794"},"modified":"2020-05-13T04:30:08","modified_gmt":"2020-05-13T02:30:08","slug":"40794","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=40794","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abLa prote\u00edna de liberaci\u00f3n de endotoxinas HMGB1 media la letalidad dependiente de caspasa-11 en la sepsis\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-_OgvWkUYxt0\/Xrv8EA2Su-I\/AAAAAAAAczY\/OeoibhM43EIljf6tAZXzew3FSKpAKfDrACLcBGAsYHQ\/s1600\/Immunity.gif\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-_OgvWkUYxt0\/Xrv8EA2Su-I\/AAAAAAAAczY\/OeoibhM43EIljf6tAZXzew3FSKpAKfDrACLcBGAsYHQ\/s1600\/Immunity.gif\" border=\"0\" data-original-width=\"116\" data-original-height=\"150\" \/><\/a>Deng, M., Tang, Y., Li, W., Wang, X., Zhang, R., Zhang, X., &#8230; &amp; Huang, Y. (2018).\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1074761318303790\">The endotoxin delivery protein HMGB1 mediates caspase-11-dependent lethality in sepsis<\/a>.\u00a0<i>Immunity,<\/i>\u00a049(4), 740-753.<\/p>\n<div>La caspasa-11 , un receptor de endotoxina citos\u00f3lica (lipopolisac\u00e1rido: LPS) , media la piroptosis , una forma l\u00edtica de muerte celular. La piroptosis dependiente de caspasa-11 media la letalidad en la endotoxemia , pero no est\u00e1 claro c\u00f3mo se administra LPS al citosol para la activaci\u00f3n de caspasa-11.<\/div>\n<div>\u00a0<\/div>\n<div>Aqu\u00ed descubrimos que la caja 1 del grupo de alta movilidad liberada por hepatocitos (HMGB1) era necesaria para la piroptosis dependiente de caspasa-11 y la letalidad en endotoxemia y sepsis bacteriana.<\/div>\n<div>\u00a0<\/div>\n<div>Mec\u00e1nicamente, el HMGB1 liberado por hepatocitos se uni\u00f3 a LPS y apunt\u00f3 a su internalizaci\u00f3n en los lisosomas de los macr\u00f3fagos y las c\u00e9lulas endoteliales.a trav\u00e9s del receptor para productos finales de glicaci\u00f3n avanzada (RAGE). Posteriormente, HMGB1 permeabiliz\u00f3 la bicapa de fosfol\u00edpidos en el ambiente \u00e1cido de los lisosomas. Esto dio como resultado una fuga de LPS en el citosol y la activaci\u00f3n de caspasa-11.<\/div>\n<div>\u00a0<\/div>\n<div>El agotamiento del hepatocito HMGB1, la inhibici\u00f3n de la liberaci\u00f3n de hepatocito HMGB1, la neutralizaci\u00f3n de HMGB1 extracelular neutralizante o la deficiencia de RAGE impidieron la piroptosis dependiente de caspasa-11 y la muerte en endotoxemia y sepsis bacteriana.<\/div>\n<div>\u00a0<\/div>\n<div>Estos hallazgos indican que HMGB1 interact\u00faa con LPS para mediar la piroptosis dependiente de caspasa-11 en la sepsis letal.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Deng, M., Tang, Y., Li, W., Wang, X., Zhang, R., Zhang, X., &#8230; &amp; Huang, Y. (2018).\u00a0The endotoxin delivery protein HMGB1 mediates caspase-11-dependent lethality in sepsis.\u00a0Immunity,\u00a049(4), 740-753. La caspasa-11 , un receptor de endotoxina citos\u00f3lica (lipopolisac\u00e1rido: LPS) , media la piroptosis , una forma l\u00edtica de muerte celular. La piroptosis dependiente de caspasa-11 media la [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-40794","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;La prote\u00edna de liberaci\u00f3n de endotoxinas HMGB1 media la letalidad dependiente de caspasa-11 en la sepsis&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=40794\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;La prote\u00edna de liberaci\u00f3n de endotoxinas HMGB1 media la letalidad dependiente de caspasa-11 en la sepsis&quot; -\" \/>\n<meta property=\"og:description\" content=\"Deng, M., Tang, Y., Li, W., Wang, X., Zhang, R., Zhang, X., &#8230; &amp; Huang, Y. (2018).\u00a0The endotoxin delivery protein HMGB1 mediates caspase-11-dependent lethality in sepsis.\u00a0Immunity,\u00a049(4), 740-753. La caspasa-11 , un receptor de endotoxina citos\u00f3lica (lipopolisac\u00e1rido: LPS) , media la piroptosis , una forma l\u00edtica de muerte celular. 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