{"id":40876,"date":"2020-05-14T05:30:36","date_gmt":"2020-05-14T03:30:36","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=40876"},"modified":"2020-05-14T05:30:36","modified_gmt":"2020-05-14T03:30:36","slug":"40876","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=40876","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abLa endotoxina derivada del intestino contribuye a la inflamaci\u00f3n en la lesi\u00f3n renal aguda isqu\u00e9mica grave\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-qIhxvnLDlGI\/Xr1srqi9h_I\/AAAAAAAAc2E\/RgbqmO719eoEc7_aXTWd9aRPMHd0whANACLcBGAsYHQ\/s1600\/BMC_nephrology.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-qIhxvnLDlGI\/Xr1srqi9h_I\/AAAAAAAAc2E\/RgbqmO719eoEc7_aXTWd9aRPMHd0whANACLcBGAsYHQ\/s1600\/BMC_nephrology.jpg\" border=\"0\" data-original-width=\"111\" data-original-height=\"156\" \/><\/a>Li, J., Moturi, K. R., Wang, L., Zhang, K., &amp; Yu, C. (2019).\u00a0<a href=\"https:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/s12882-018-1199-4\">Gut derived-endotoxin contributes to inflammation in severe ischemic acute kidney injury<\/a>.\u00a0<i>BMC nephrology<\/i>, 20(1), 1-9.<\/p>\n<p>ANTECEDENTES: Investigaciones recientes indican que las consecuencias intestinales de la isquemia-reperfusi\u00f3n renal (IR) predisponen a la translocaci\u00f3n de endotoxina derivada del intestino. Aqu\u00ed, dise\u00f1amos experimentos para probar la hip\u00f3tesis de que la endotoxina derivada del intestino tiene un papel potencial en la mediaci\u00f3n de los procesos inflamatorios locales en el ri\u00f1\u00f3n con lesi\u00f3n aguda.<\/p>\n<p>\nM\u00c9TODOS: Las ratas se realizaron cirug\u00eda simulada o IR renal (60 min de isquemia renal bilateral, luego 24 h de reperfusi\u00f3n) ( n \u2009= 5). Se evalu\u00f3 la permeabilidad de la mucosa y la estructura intestinal. Se midieron la endotoxina s\u00e9rica y la carga bacteriana en el h\u00edgado y los ganglios linf\u00e1ticos mesent\u00e9ricos (MLN). Se pretrataron grupos separados con norfloxacina oral 20 mg \/ kg \/ d\u00eda o soluci\u00f3n salina durante 4 semanas y se dividieron en simulado m\u00e1s soluci\u00f3n salina, simulado m\u00e1s norfloxacina, IR renal m\u00e1s soluci\u00f3n salina e IR renal m\u00e1s grupo de norfloxacina. Se determinaron la bioqu\u00edmica s\u00e9rica y la endotoxina. Se puntuaron los cambios patol\u00f3gicos renales. La prote\u00edna o la expresi\u00f3n de ARNm del receptor tipo toll 4 (TLR4) y los mediadores proinflamatorios se midieron en homogeneizado de ri\u00f1\u00f3n.<\/p>\n<p>\nRESULTADOS: La IR renal condujo a una alteraci\u00f3n marcada de la integridad intestinal y al aumento de la permeabilidad intestinal. Estos est\u00e1n acompa\u00f1ados por un bajo grado de endotoxemia, as\u00ed como un aumento de la carga bacteriana en el h\u00edgado y MLN. El grupo pretratado con norfloxacina mostr\u00f3 una atenuaci\u00f3n significativa del aumento de urea s\u00e9rica, ALAT, ASAT y endotoxina. El aumento de la prote\u00edna renal o ARNm de TLR4 y mediadores proinflamatorios (IL-6 y MCP-1) en los animales no pretratados se atenu\u00f3 significativamente en los animales pretratados con norfloxacina. Sin embargo, el pretratamiento con norfloxacina no produjo ning\u00fan efecto protector sobre la integridad tubular renal.<\/p>\n<p>CONCLUSIONES: Nuestros resultados muestran por primera vez que la endotoxina derivada del intestino, como resultado de una mayor permeabilidad intestinal despu\u00e9s de IR renal severa, amplifica posteriormente la respuesta inflamatoria intrarrenal mediante la activaci\u00f3n de la se\u00f1alizaci\u00f3n renal de TLR4. Los resultados de nuestro estudio no establecen que la administraci\u00f3n de antibi\u00f3ticos sea efectiva para mejorar el resultado renal general. Sin embargo, nuestros hallazgos pueden ser el primer paso para comprender c\u00f3mo adaptar las terapias para mitigar la inflamaci\u00f3n intrarrenal en grupos seleccionados de pacientes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Li, J., Moturi, K. R., Wang, L., Zhang, K., &amp; Yu, C. (2019).\u00a0Gut derived-endotoxin contributes to inflammation in severe ischemic acute kidney injury.\u00a0BMC nephrology, 20(1), 1-9. ANTECEDENTES: Investigaciones recientes indican que las consecuencias intestinales de la isquemia-reperfusi\u00f3n renal (IR) predisponen a la translocaci\u00f3n de endotoxina derivada del intestino. Aqu\u00ed, dise\u00f1amos experimentos para probar la hip\u00f3tesis [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-40876","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;La endotoxina derivada del intestino contribuye a la inflamaci\u00f3n en la lesi\u00f3n renal aguda isqu\u00e9mica grave&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=40876\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;La endotoxina derivada del intestino contribuye a la inflamaci\u00f3n en la lesi\u00f3n renal aguda isqu\u00e9mica grave&quot; -\" \/>\n<meta property=\"og:description\" content=\"Li, J., Moturi, K. R., Wang, L., Zhang, K., &amp; Yu, C. (2019).\u00a0Gut derived-endotoxin contributes to inflammation in severe ischemic acute kidney injury.\u00a0BMC nephrology, 20(1), 1-9. ANTECEDENTES: Investigaciones recientes indican que las consecuencias intestinales de la isquemia-reperfusi\u00f3n renal (IR) predisponen a la translocaci\u00f3n de endotoxina derivada del intestino. Aqu\u00ed, dise\u00f1amos experimentos para probar la hip\u00f3tesis [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=40876\" \/>\n<meta property=\"article:published_time\" content=\"2020-05-14T03:30:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-qIhxvnLDlGI\/Xr1srqi9h_I\/AAAAAAAAc2E\/RgbqmO719eoEc7_aXTWd9aRPMHd0whANACLcBGAsYHQ\/s1600\/BMC_nephrology.jpg\" \/>\n<meta name=\"author\" content=\"admin2\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin2\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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