{"id":41357,"date":"2020-05-25T03:30:24","date_gmt":"2020-05-25T01:30:24","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=41357"},"modified":"2020-05-25T03:30:24","modified_gmt":"2020-05-25T01:30:24","slug":"41357","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=41357","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abViroma de ADN de doble cadena de la piel humana: diversidad topogr\u00e1fica y temporal, enriquecimiento gen\u00e9tico y asociaciones din\u00e1micas con el microbioma del hu\u00e9sped\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-YDFj6h8Hqg4\/XsrS8X7LsrI\/AAAAAAAAdFc\/j82rEujQ_0IqhywjhiULEudD1r14hFDjwCLcBGAsYHQ\/s1600\/Mbio.png\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-YDFj6h8Hqg4\/XsrS8X7LsrI\/AAAAAAAAdFc\/j82rEujQ_0IqhywjhiULEudD1r14hFDjwCLcBGAsYHQ\/s1600\/Mbio.png\" border=\"0\" data-original-width=\"234\" data-original-height=\"215\" \/><\/a>Hannigan, G. D., Meisel, J. S., Tyldsley, A. S., Zheng, Q., Hodkinson, B. P., SanMiguel, A. J., &#8230; &amp; Grice, E. A. (2015).\u00a0<a href=\"https:\/\/mbio.asm.org\/content\/mbio\/6\/5\/e01578-15.full.pdf\">The human skin double-stranded DNA virome: topographical and temporal diversity, genetic enrichment, and dynamic associations with the host microbiome<\/a>.\u00a0<i>MBio<\/i>, 6(5), e01578-15.<\/p>\n<p>Los virus constituyen un componente importante de la microbiota humana, pero son poco conocidos en la piel, nuestra principal barrera para el medio ambiente externo. Las comunidades virales tienen el potencial de modular estados de salud y enfermedad cut\u00e1neas. Se sabe que los bacteri\u00f3fagos influyen en la estructura y funci\u00f3n de las comunidades microbianas a trav\u00e9s de la depredaci\u00f3n y el intercambio gen\u00e9tico. Los virus humanos est\u00e1n asociados con c\u00e1nceres de piel y una multitud de manifestaciones cut\u00e1neas.\u00a0<\/p>\n<p>A pesar de estos importantes roles, se sabe poco sobre el viroma de la piel humana y sus interacciones con el microbioma del hu\u00e9sped. Aqu\u00ed evaluamos el viroma de ADN bicatenario cut\u00e1neo humano mediante secuenciaci\u00f3n metagen\u00f3mica de ADN a partir de part\u00edculas similares a virus purificadas (VLP).<\/p>\n<p>En paralelo, rmpleamos la secuencia metagen\u00f3mica del microbioma total de la piel para evaluar la covarianza e inferir las interacciones con el viroma. Se recogieron muestras de 16 sujetos en ocho sitios del cuerpo durante 1 mes. Adem\u00e1s del microambiente, que se sabe que reparte la microbiota bacteriana y f\u00fangica, la oclusi\u00f3n natural de la piel estaba fuertemente asociada con la composici\u00f3n de la comunidad del viroma de la piel.\u00a0<\/p>\n<p>Los contigs virales se enriquecieron con genes indicativos de un estilo de replicaci\u00f3n de fagos templados y tambi\u00e9n mantuvieron genes que codifican posibles factores de resistencia a los antibi\u00f3ticos y de virulencia. Los separadores CRISPR identificados en las secuencias de ADN bacteriano proporcionaron un registro de la depredaci\u00f3n de fagos y sugieren un mecanismo para explicar la divisi\u00f3n espacial de las comunidades de fagos de la piel. Finalmente, modelamos la estructura de comunidades bacterianas y de fagos juntas para revelar un entorno microbiano complejo con un centro Corynebacterium. Estos resultados revelan la diversidad previamente infravalorada, las funciones codificadas y la din\u00e1mica viral-microbiana exclusiva del viroma de la piel humana.<\/p>\n<p>IMPORTANCIA: Hasta la fecha, la mayor\u00eda de los estudios de microbiomas cut\u00e1neos se han centrado en comunidades bacterianas y f\u00fangicas. Las comunidades virales de la piel y sus relaciones con sus anfitriones siguen siendo poco conocidas a pesar de su potencial para modular estados de salud y enfermedad cut\u00e1neas. Estudios previos que emplearon la secuenciaci\u00f3n de metagenomas completos sin purificaci\u00f3n para part\u00edculas similares a virus (VLP) han proporcionado una idea del componente viral del microbioma de la piel, pero no han caracterizado completamente estas comunidades o analizado las interacciones con el microbioma del hu\u00e9sped. Aqu\u00ed presentamos una t\u00e9cnica optimizada de purificaci\u00f3n de virus y las herramientas de an\u00e1lisis correspondientes para obtener nuevos conocimientos sobre el viroma de la piel, incluida la \u00abmateria oscura\u00bb viral, y sus posibles interacciones con el microbioma del hu\u00e9sped.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hannigan, G. D., Meisel, J. S., Tyldsley, A. S., Zheng, Q., Hodkinson, B. P., SanMiguel, A. J., &#8230; &amp; Grice, E. A. (2015).\u00a0The human skin double-stranded DNA virome: topographical and temporal diversity, genetic enrichment, and dynamic associations with the host microbiome.\u00a0MBio, 6(5), e01578-15. Los virus constituyen un componente importante de la microbiota humana, pero son [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-41357","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;Viroma de ADN de doble cadena de la piel humana: diversidad topogr\u00e1fica y temporal, enriquecimiento gen\u00e9tico y asociaciones din\u00e1micas con el microbioma del hu\u00e9sped&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=41357\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;Viroma de ADN de doble cadena de la piel humana: diversidad topogr\u00e1fica y temporal, enriquecimiento gen\u00e9tico y asociaciones din\u00e1micas con el microbioma del hu\u00e9sped&quot; -\" \/>\n<meta property=\"og:description\" content=\"Hannigan, G. D., Meisel, J. S., Tyldsley, A. S., Zheng, Q., Hodkinson, B. P., SanMiguel, A. J., &#8230; &amp; Grice, E. A. (2015).\u00a0The human skin double-stranded DNA virome: topographical and temporal diversity, genetic enrichment, and dynamic associations with the host microbiome.\u00a0MBio, 6(5), e01578-15. 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