{"id":42076,"date":"2020-06-10T01:30:54","date_gmt":"2020-06-09T23:30:54","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=42076"},"modified":"2020-06-10T01:30:54","modified_gmt":"2020-06-09T23:30:54","slug":"42076","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=42076","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl resveratrol causa la detenci\u00f3n de la fase G del ciclo celular mediada por WAF \u2010 1 \/ p21 y la inducci\u00f3n de apoptosis en c\u00e9lulas de carcinoma epidermoide humano A431\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-nmS6tYCy9C8\/XuEqNVKwqdI\/AAAAAAAAdd8\/QrgXH0SvsC0o7iMPZ5IMynNhygj81hFZwCLcBGAsYHQ\/s1600\/Clinical_Cancer_Research.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-nmS6tYCy9C8\/XuEqNVKwqdI\/AAAAAAAAdd8\/QrgXH0SvsC0o7iMPZ5IMynNhygj81hFZwCLcBGAsYHQ\/s320\/Clinical_Cancer_Research.jpg\" width=\"240\" height=\"320\" border=\"0\" data-original-width=\"838\" data-original-height=\"1113\" \/><\/a>Ahmad, N., Adhami, V. M., Afaq, F., Feyes, D. K., &amp; Mukhtar, H. (2001).\u00a0<a href=\"http:\/\/clincancerres.aacrjournals.org\/content\/7\/5\/1466.full\">Resveratrol causes WAF-1\/p21-mediated G1-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells<\/a>.\u00a0<i>Clinical Cancer Research<\/i>, 7(5), 1466-1473.\u00a0<\/p>\n<p>El resveratrol (trans -3,4 &#8216;, 5, -trihydroxystilbene), una fitoalexina que se encuentra en las uvas, nueces, frutas y vino tinto, es un potente antioxidante con propiedades preventivas del c\u00e1ncer. El mecanismo por el cual el resveratrol imparte efectos quimiopreventivos contra el c\u00e1ncer no est\u00e1 claramente definido.\u00a0<\/p>\n<p>Aqu\u00ed, se demuestra que el resveratrol, a trav\u00e9s de modulaciones en quinasa dependiente de ciclina (cdk) maquinaria inhibidor-ciclina-CDK, los resultados en un G 1 -Fase detenci\u00f3n del ciclo celular seguido de la apoptosis de c\u00e9lulas de carcinoma epidermoide humano (A431).\u00a0<\/p>\n<p>El tratamiento con resveratrol (1-50 \u03bc m durante 24 h) de c\u00e9lulas A431 dio como resultado una inhibici\u00f3n dependiente de la dosis ( a ) del crecimiento celular como se muestra por 3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium ensayo de bromuro, ( b ) G 1-fase de detenci\u00f3n del ciclo celular como se muestra por el an\u00e1lisis del ciclo celular del ADN, y ( c ) la inducci\u00f3n de la apoptosis evaluada por ELISA. El an\u00e1lisis de inmunotransferencia revel\u00f3 que el tratamiento con resveratrol causa una inducci\u00f3n dependiente de la dosis y del tiempo ( a ) de WAF1 \/ p21; ( b ) disminuci\u00f3n en las expresiones proteicas de ciclina D1, ciclina D2 y ciclina E; y ( c) disminuci\u00f3n en las expresiones de prote\u00ednas de cdk2, cdk4 y cdk6.\u00a0<\/p>\n<p>Tambi\u00e9n se encontr\u00f3 que el tratamiento con resveratrol da como resultado una disminuci\u00f3n dependiente de la dosis y del tiempo en las actividades de cinasa asociadas con todas las cdks examinadas. Tomados en conjunto, nuestro estudio sugiere que el tratamiento con resveratrol de las c\u00e9lulas provoca una inducci\u00f3n de WAF1 \/ p21 que inhibe los complejos de ciclina D1 \/ D2-cdk6, ciclina D1 \/ D2-cdk4 y ciclina E-cdk2, imponiendo un punto de control artificial en la G 1 \u2192 S transici\u00f3n del ciclo celular.\u00a0<\/p>\n<p>Esta serie de eventos da como resultado una G 1-Fase de detenci\u00f3n del ciclo celular, que es un proceso irreversible que finalmente resulta en la muerte apopt\u00f3tica de las c\u00e9lulas cancerosas.\u00a0<\/p>\n<p>Hasta donde sabemos, este es el primer estudio sistem\u00e1tico que muestra la participaci\u00f3n de cada componente de la maquinaria cdk inhibidor-ciclina-cdk durante la detenci\u00f3n del ciclo celular y la apoptosis de las c\u00e9lulas cancerosas por el resveratrol.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ahmad, N., Adhami, V. M., Afaq, F., Feyes, D. K., &amp; Mukhtar, H. (2001).\u00a0Resveratrol causes WAF-1\/p21-mediated G1-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells.\u00a0Clinical Cancer Research, 7(5), 1466-1473.\u00a0 El resveratrol (trans -3,4 &#8216;, 5, -trihydroxystilbene), una fitoalexina que se encuentra en las uvas, nueces, frutas y vino tinto, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-42076","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El resveratrol causa la detenci\u00f3n de la fase G del ciclo celular mediada por WAF \u2010 1 \/ p21 y la inducci\u00f3n de apoptosis en c\u00e9lulas de carcinoma epidermoide humano A431&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=42076\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El resveratrol causa la detenci\u00f3n de la fase G del ciclo celular mediada por WAF \u2010 1 \/ p21 y la inducci\u00f3n de apoptosis en c\u00e9lulas de carcinoma epidermoide humano A431&quot; -\" \/>\n<meta property=\"og:description\" content=\"Ahmad, N., Adhami, V. 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