{"id":42085,"date":"2020-06-10T04:30:02","date_gmt":"2020-06-10T02:30:02","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=42085"},"modified":"2020-06-10T04:30:02","modified_gmt":"2020-06-10T02:30:02","slug":"42085","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=42085","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl resveratrol induce una extensa apoptosis despolarizando las membranas mitocondriales y activando la caspasa-9 en las c\u00e9lulas de leucemia linfobl\u00e1stica aguda\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-DjyD9aX-Rfo\/XuEwimCNrSI\/AAAAAAAAdeU\/SDJhahw6dHA46L7-TyGK5dc-A04rpczawCLcBGAsYHQ\/s1600\/Cancer_Research.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-DjyD9aX-Rfo\/XuEwimCNrSI\/AAAAAAAAdeU\/SDJhahw6dHA46L7-TyGK5dc-A04rpczawCLcBGAsYHQ\/s1600\/Cancer_Research.jpg\" border=\"0\" data-original-width=\"240\" data-original-height=\"310\" \/><\/a>D\u00f6rrie, J., Gerauer, H., Wachter, Y., &amp; Zunino, S. J. (2001).\u00a0<a href=\"https:\/\/cancerres.aacrjournals.org\/content\/canres\/61\/12\/4731.full.pdf\">Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells<\/a>.\u00a0<i>Cancer research,<\/i>\u00a061(12), 4731-4739.\u00a0<\/p>\n<p>Se ha descubierto que el resveratrol, un antibi\u00f3tico vegetal, tiene actividad anticancer\u00edgena y recientemente se inform\u00f3 que induce apoptosis en la l\u00ednea de leucemia mieloide HL60 por la v\u00eda del ligando CD95-CD95. Sin embargo, muchas leucemias linfobl\u00e1sticas agudas (LLA), particularmente de linaje B, son resistentes a la apoptosis mediada por CD95.\u00a0<\/p>\n<p>Usando l\u00edneas de leucemia derivadas de pacientes con LLA pro-B t (4; 11), pre-B y de c\u00e9lulas T, mostramos en este informe que el resveratrol induce la muerte celular apopt\u00f3tica extensa no solo en las l\u00edneas de leucemia sensibles a CD95, sino tambi\u00e9n en c\u00e9lulas leuc\u00e9micas de linaje B que son resistentes a la se\u00f1alizaci\u00f3n de CD95.\u00a0<\/p>\n<p>Los tratamientos de dosis m\u00faltiples de las c\u00e9lulas leuc\u00e9micas con resveratrol 50 microM resultaron en&gt; \/ = 80% de muerte celular sin citotoxicidad estad\u00edsticamente significativa contra c\u00e9lulas mononucleares de sangre perif\u00e9rica normales en condiciones id\u00e9nticas. El tratamiento con resveratrol no aument\u00f3 la expresi\u00f3n de CD95 ni dispar\u00f3 la sensibilidad a la apoptosis mediada por CD95 en las l\u00edneas ALL. La inhibici\u00f3n de la se\u00f1alizaci\u00f3n de CD95 con un anticuerpo antagonista espec\u00edfico de CD95 indic\u00f3 que las interacciones de ligando CD95-CD95 no estaban involucradas en el inicio de la apoptosis inducida por resveratrol. Sin embargo, en cada l\u00ednea de ALL, el resveratrol indujo la p\u00e9rdida progresiva del potencial de membrana mitocondrial medido por el patr\u00f3n de emisi\u00f3n dual del colorante selectivo de mitocondrias JC-1.\u00a0<\/p>\n<p>El inhibidor de la caspasa de amplio espectro benciloxicarbonil-Val-Ala-Asp-fluorometilcetona no pudo bloquear la despolarizaci\u00f3n de las membranas mitocondriales inducidas por el resveratrol, lo que indica que la acci\u00f3n del resveratrol fue independiente de la activaci\u00f3n de la caspasa-8 aguas arriba a trav\u00e9s de la ligadura del receptor. Sin embargo, Los aumentos en la actividad de la caspasa-9 oscilaron entre 4 y 9 veces en las ocho l\u00edneas celulares despu\u00e9s del tratamiento con resveratrol.\u00a0<\/p>\n<p>Tomados en conjunto, estos resultados apuntan a un mecanismo general de inducci\u00f3n de apoptosis por resveratrol en todas las c\u00e9lulas que involucra una v\u00eda espec\u00edfica de mitocondrias \/ caspasa-9 para la activaci\u00f3n de la cascada de caspasa y es independiente de la se\u00f1alizaci\u00f3n de CD95.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>D\u00f6rrie, J., Gerauer, H., Wachter, Y., &amp; Zunino, S. J. (2001).\u00a0Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells.\u00a0Cancer research,\u00a061(12), 4731-4739.\u00a0 Se ha descubierto que el resveratrol, un antibi\u00f3tico vegetal, tiene actividad anticancer\u00edgena y recientemente se inform\u00f3 que induce apoptosis en la l\u00ednea de leucemia mieloide HL60 por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-42085","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El resveratrol induce una extensa apoptosis despolarizando las membranas mitocondriales y activando la caspasa-9 en las c\u00e9lulas de leucemia linfobl\u00e1stica aguda&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=42085\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El resveratrol induce una extensa apoptosis despolarizando las membranas mitocondriales y activando la caspasa-9 en las c\u00e9lulas de leucemia linfobl\u00e1stica aguda&quot; -\" \/>\n<meta property=\"og:description\" content=\"D\u00f6rrie, J., Gerauer, H., Wachter, Y., &amp; Zunino, S. J. (2001).\u00a0Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells.\u00a0Cancer research,\u00a061(12), 4731-4739.\u00a0 Se ha descubierto que el resveratrol, un antibi\u00f3tico vegetal, tiene actividad anticancer\u00edgena y recientemente se inform\u00f3 que induce apoptosis en la l\u00ednea de leucemia mieloide HL60 por [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=42085\" \/>\n<meta property=\"article:published_time\" content=\"2020-06-10T02:30:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-DjyD9aX-Rfo\/XuEwimCNrSI\/AAAAAAAAdeU\/SDJhahw6dHA46L7-TyGK5dc-A04rpczawCLcBGAsYHQ\/s1600\/Cancer_Research.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=42085#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=42085\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl resveratrol induce una extensa apoptosis despolarizando las membranas mitocondriales y activando la caspasa-9 en las c\u00e9lulas de leucemia linfobl\u00e1stica aguda\u00bb\",\"datePublished\":\"2020-06-10T02:30:02+00:00\",\"dateModified\":\"2020-06-10T02:30:02+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=42085\"},\"wordCount\":448,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"articleSection\":[\"Sustancias Bioactivas\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=42085#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=42085\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?p=42085\",\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \\\"El resveratrol induce una extensa apoptosis despolarizando las membranas mitocondriales y activando la caspasa-9 en las c\u00e9lulas de leucemia linfobl\u00e1stica aguda\\\" -\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\"},\"datePublished\":\"2020-06-10T02:30:02+00:00\",\"dateModified\":\"2020-06-10T02:30:02+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=42085#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=42085\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=42085#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/rina.naturopatiadigital.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl resveratrol induce una extensa apoptosis despolarizando las membranas mitocondriales y activando la caspasa-9 en las c\u00e9lulas de leucemia linfobl\u00e1stica aguda\u00bb\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"name\":\"\",\"description\":\"Red Investigaci\u00f3n Naturop\u00e1tica\",\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\",\"name\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"contentUrl\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"width\":960,\"height\":960,\"caption\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\"},\"image\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/rina.naturopatiadigital.eu\"],\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"El resveratrol induce una extensa apoptosis despolarizando las membranas mitocondriales y activando la caspasa-9 en las c\u00e9lulas de leucemia linfobl\u00e1stica aguda\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=42085","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"El resveratrol induce una extensa apoptosis despolarizando las membranas mitocondriales y activando la caspasa-9 en las c\u00e9lulas de leucemia linfobl\u00e1stica aguda\" -","og_description":"D\u00f6rrie, J., Gerauer, H., Wachter, Y., &amp; Zunino, S. J. (2001).\u00a0Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells.\u00a0Cancer research,\u00a061(12), 4731-4739.\u00a0 Se ha descubierto que el resveratrol, un antibi\u00f3tico vegetal, tiene actividad anticancer\u00edgena y recientemente se inform\u00f3 que induce apoptosis en la l\u00ednea de leucemia mieloide HL60 por [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=42085","article_published_time":"2020-06-10T02:30:02+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/-DjyD9aX-Rfo\/XuEwimCNrSI\/AAAAAAAAdeU\/SDJhahw6dHA46L7-TyGK5dc-A04rpczawCLcBGAsYHQ\/s1600\/Cancer_Research.jpg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=42085#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=42085"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl resveratrol induce una extensa apoptosis despolarizando las membranas mitocondriales y activando la caspasa-9 en las c\u00e9lulas de leucemia linfobl\u00e1stica aguda\u00bb","datePublished":"2020-06-10T02:30:02+00:00","dateModified":"2020-06-10T02:30:02+00:00","mainEntityOfPage":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=42085"},"wordCount":448,"commentCount":0,"publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"articleSection":["Sustancias Bioactivas"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rina.naturopatiadigital.eu\/?p=42085#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=42085","url":"https:\/\/rina.naturopatiadigital.eu\/?p=42085","name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"El resveratrol induce una extensa apoptosis despolarizando las membranas mitocondriales y activando la caspasa-9 en las c\u00e9lulas de leucemia linfobl\u00e1stica aguda\" -","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#website"},"datePublished":"2020-06-10T02:30:02+00:00","dateModified":"2020-06-10T02:30:02+00:00","breadcrumb":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=42085#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rina.naturopatiadigital.eu\/?p=42085"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=42085#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/rina.naturopatiadigital.eu\/"},{"@type":"ListItem","position":2,"name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl resveratrol induce una extensa apoptosis despolarizando las membranas mitocondriales y activando la caspasa-9 en las c\u00e9lulas de leucemia linfobl\u00e1stica aguda\u00bb"}]},{"@type":"WebSite","@id":"https:\/\/rina.naturopatiadigital.eu\/#website","url":"https:\/\/rina.naturopatiadigital.eu\/","name":"","description":"Red Investigaci\u00f3n Naturop\u00e1tica","publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/rina.naturopatiadigital.eu\/#organization","name":"Organizaci\u00f3n Colegial Naturop\u00e1tica","url":"https:\/\/rina.naturopatiadigital.eu\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/","url":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","contentUrl":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","width":960,"height":960,"caption":"Organizaci\u00f3n Colegial Naturop\u00e1tica"},"image":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7","name":"admin","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/rina.naturopatiadigital.eu"],"url":"https:\/\/rina.naturopatiadigital.eu\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/42085","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=42085"}],"version-history":[{"count":0,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/42085\/revisions"}],"wp:attachment":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=42085"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=42085"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=42085"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}