{"id":42088,"date":"2020-06-10T05:30:52","date_gmt":"2020-06-10T03:30:52","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=42088"},"modified":"2020-06-10T05:30:52","modified_gmt":"2020-06-10T03:30:52","slug":"42088","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=42088","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abMuerte apopt\u00f3tica inducida por resveratrol en c\u00e9lulas de glioma humano U251\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-3m7EbmeLRB0\/XuEx-FXtW2I\/AAAAAAAAdec\/kSMCRF44c4YG5t4Sjx_4sfPtTcgbZem2wCLcBGAsYHQ\/s1600\/Molecular_Cancer%2BTherapeutics.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-3m7EbmeLRB0\/XuEx-FXtW2I\/AAAAAAAAdec\/kSMCRF44c4YG5t4Sjx_4sfPtTcgbZem2wCLcBGAsYHQ\/s1600\/Molecular_Cancer%2BTherapeutics.jpg\" border=\"0\" data-original-width=\"195\" data-original-height=\"259\" \/><\/a>Jiang, H., Zhang, L., Kuo, J., Kuo, K., Gautam, S. C., Groc, L., &#8230; &amp; Seidman, M. D. (2005).\u00a0<a href=\"https:\/\/mct.aacrjournals.org\/content\/molcanther\/4\/4\/554.full.pdf\">Resveratrol-induced apoptotic death in human U251 glioma cells<\/a>.\u00a0<i>Molecular cancer therapeutics<\/i>, 4(4), 554-561.<\/p>\n<p>El resveratrol (trans-3,4 &#8216;, 5-trihidroxistilbeno) es un compuesto polifen\u00f3lico natural altamente enriquecido en uvas, man\u00ed, vino tinto y una variedad de fuentes de alimentos. El resveratrol tiene propiedades antiinflamatorias y antioxidantes, y tambi\u00e9n tiene potentes propiedades anticancer\u00edgenas.\u00a0<\/p>\n<p>Las c\u00e9lulas de glioma humano U251 se usaron para comprender los mecanismos moleculares por los cuales el resveratrol act\u00faa como un agente anticancer\u00edgeno, ya que el glioma es un c\u00e1ncer particularmente dif\u00edcil de tratar y erradicar.\u00a0<\/p>\n<p>Nuestros datos muestran que el resveratrol induce la muerte dependiente de la dosis y el tiempo de las c\u00e9lulas U251, seg\u00fan lo medido por la liberaci\u00f3n de lactato deshidrogenasa y los ensayos de fragmentaci\u00f3n de ADN internucleosomal. El resveratrol induce la activaci\u00f3n de caspasa-3 y aumenta la escisi\u00f3n del sustrato de caspasa aguas abajo, la polimerasa poli (ADP-ribosa). La fragmentaci\u00f3n del ADN inducida por el resveratrol puede ser completamente bloqueada por un inhibidor general de caspasa (Z-VAD-FMK) o un inhibidor selectivo de caspasa-3 (Z-DEVD-FMK), pero no por un inhibidor selectivo de caspasa-1. El resveratrol induce la liberaci\u00f3n de citocromo c de las mitocondrias al citoplasma y la activaci\u00f3n de la caspasa-9.\u00a0<\/p>\n<p>El resveratrol tambi\u00e9n aumenta la expresi\u00f3n de Bax proapopt\u00f3tico y su translocaci\u00f3n a las mitocondrias. El resveratrol inhibe la proliferaci\u00f3n de U251, medido por el ensayo MTS [3- (4,5-dimetiltiazol-2-il) -5- (3-carboximetoxifenil) -2- (4-sulfofenil) -2H-tetrazolio, sal interna], y induce la detenci\u00f3n del crecimiento G0 \/ G1, seg\u00fan lo determinado por citometr\u00eda de flujo. El inhibidor de la quinasa dependiente de ciclina, la olomoucina, previene la progresi\u00f3n del ciclo celular y la apoptosis inducida por el resveratrol.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jiang, H., Zhang, L., Kuo, J., Kuo, K., Gautam, S. C., Groc, L., &#8230; &amp; Seidman, M. D. (2005).\u00a0Resveratrol-induced apoptotic death in human U251 glioma cells.\u00a0Molecular cancer therapeutics, 4(4), 554-561. El resveratrol (trans-3,4 &#8216;, 5-trihidroxistilbeno) es un compuesto polifen\u00f3lico natural altamente enriquecido en uvas, man\u00ed, vino tinto y una variedad de fuentes de alimentos. El [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-42088","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Muerte apopt\u00f3tica inducida por resveratrol en c\u00e9lulas de glioma humano U251&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=42088\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Muerte apopt\u00f3tica inducida por resveratrol en c\u00e9lulas de glioma humano U251&quot; -\" \/>\n<meta property=\"og:description\" content=\"Jiang, H., Zhang, L., Kuo, J., Kuo, K., Gautam, S. C., Groc, L., &#8230; &amp; Seidman, M. D. (2005).\u00a0Resveratrol-induced apoptotic death in human U251 glioma cells.\u00a0Molecular cancer therapeutics, 4(4), 554-561. El resveratrol (trans-3,4 &#8216;, 5-trihidroxistilbeno) es un compuesto polifen\u00f3lico natural altamente enriquecido en uvas, man\u00ed, vino tinto y una variedad de fuentes de alimentos. El [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=42088\" \/>\n<meta property=\"article:published_time\" content=\"2020-06-10T03:30:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-3m7EbmeLRB0\/XuEx-FXtW2I\/AAAAAAAAdec\/kSMCRF44c4YG5t4Sjx_4sfPtTcgbZem2wCLcBGAsYHQ\/s1600\/Molecular_Cancer%2BTherapeutics.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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c\u00e9lulas de glioma humano U251\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=42088","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"Muerte apopt\u00f3tica inducida por resveratrol en c\u00e9lulas de glioma humano U251\" -","og_description":"Jiang, H., Zhang, L., Kuo, J., Kuo, K., Gautam, S. C., Groc, L., &#8230; &amp; Seidman, M. D. (2005).\u00a0Resveratrol-induced apoptotic death in human U251 glioma cells.\u00a0Molecular cancer therapeutics, 4(4), 554-561. El resveratrol (trans-3,4 &#8216;, 5-trihidroxistilbeno) es un compuesto polifen\u00f3lico natural altamente enriquecido en uvas, man\u00ed, vino tinto y una variedad de fuentes de alimentos. 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