{"id":42091,"date":"2020-06-10T06:30:41","date_gmt":"2020-06-10T04:30:41","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=42091"},"modified":"2020-06-10T06:30:41","modified_gmt":"2020-06-10T04:30:41","slug":"42091","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=42091","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa fosforilaci\u00f3n de serina inducida por resveratrol de p53 causa apoptosis en una l\u00ednea celular mutante de c\u00e1ncer de pr\u00f3stata p53\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-cJrTbbh1pnk\/XuEzox5RhUI\/AAAAAAAAdek\/RR8AKdpFPMMyLA2LnJYdZkjhql48-dQVACLcBGAsYHQ\/s1600\/Journal_Urology.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-cJrTbbh1pnk\/XuEzox5RhUI\/AAAAAAAAdek\/RR8AKdpFPMMyLA2LnJYdZkjhql48-dQVACLcBGAsYHQ\/s320\/Journal_Urology.jpg\" width=\"239\" height=\"320\" border=\"0\" data-original-width=\"574\" data-original-height=\"768\" \/><\/a>Lin, H. Y., Shih, A. I., Davis, F. B., Tang, H. Y., Martino, L. J., Bennett, J. A., &amp; Davis, P. J. (2002).\u00a0<a href=\"https:\/\/www.auajournals.org\/doi\/abs\/10.1016\/S0022-5347%2805%2964739-8\">Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line<\/a>.\u00a0<i>The Journal of urology<\/i>, 168(2), 748-755.\u00a0<\/p>\n<p>PROP\u00d3SITO: El resveratrol (Calbiochem, La Jolla, California) es un estilbeno de origen natural que se informa que causa apoptosis en varias c\u00e9lulas cancerosas cultivadas. En el estudio actual, el efecto del resveratrol se determin\u00f3 en la l\u00ednea celular de c\u00e1ncer de pr\u00f3stata DU 145 insensible a los andr\u00f3genos. Se midieron la inducci\u00f3n de apoptosis y la activaci\u00f3n de las v\u00edas de transducci\u00f3n de se\u00f1ales relacionadas con la apoptosis.\u00a0<\/p>\n<p>MATERIALES Y M\u00c9TODOS: Las c\u00e9lulas DU 145 se trataron con resveratrol y se midi\u00f3 la apoptosis determinando el contenido de nucleosomas. La activaci\u00f3n de la prote\u00edna quinasa activada por mit\u00f3geno (MAPK) (quinasa 1\/2 regulada por se\u00f1al extracelular), el contenido de p53 y la fosforilaci\u00f3n de serina-15 de p53 se midieron por inmunotransferencia. Tambi\u00e9n se realiz\u00f3 un ensayo de cambio de movilidad electrofor\u00e9tica de la uni\u00f3n de p53 al ADN, y la medici\u00f3n de p21 y ARN mensajero de la gliceraldeh\u00eddo-3-fosfato deshidrogenasa.\u00a0<\/p>\n<p>RESULTADOS: El resveratrol indujo la apoptosis en c\u00e9lulas DU 145. El estilbeno activ\u00f3 MAPK y caus\u00f3 una mayor abundancia de p53 y p53 fosforilada en serina-15. La fosforilaci\u00f3n de p53 de serina-15 inducida por resveratrol fue bloqueada por PD 98059 (Calbiochem), un inhibidor de la quinasa MAPK, lo que implica la activaci\u00f3n de MAPK en la fosforilaci\u00f3n de p53. PD 98059 tambi\u00e9n inhibi\u00f3 la apoptosis inducida por resveratrol. Estos resultados sugieren que la inducci\u00f3n de apoptosis por resveratrol en c\u00e9lulas DU 145 requiere la fosforilaci\u00f3n de serina-15 de p53 por MAPK. La inhibici\u00f3n de la fosforilaci\u00f3n de serina-15 dependiente de MAPK dio como resultado una uni\u00f3n reducida de p53 a un oligonucle\u00f3tido espec\u00edfico de p53 en el ensayo de cambio de movilidad electrofor\u00e9tica. Pifitrina-\u03b1 (Calbiochem), un inhibidor de p53, el resveratrol bloqueado indujo la fosforilaci\u00f3n de serina-15 de p53 y la uni\u00f3n de p53 al ADN. El resveratrol caus\u00f3 un aumento estimulado por p53 en el ARN mensajero p21. La transfecci\u00f3n de p53 de tipo salvaje adicional en c\u00e9lulas DU 145 indujo la apoptosis, que se mejor\u00f3 a\u00fan m\u00e1s con el tratamiento con resveratrol.\u00a0<\/p>\n<p>CONCLUSIONES: El resveratrol causa apoptosis en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata DU 145. Esta acci\u00f3n depende de la activaci\u00f3n de MAPK, el aumento en el contenido celular de p53, la fosforilaci\u00f3n de serina-15 de p53 y el aumento de la uni\u00f3n de p53 al ADN.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lin, H. Y., Shih, A. I., Davis, F. B., Tang, H. Y., Martino, L. J., Bennett, J. A., &amp; Davis, P. J. (2002).\u00a0Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line.\u00a0The Journal of urology, 168(2), 748-755.\u00a0 PROP\u00d3SITO: El resveratrol (Calbiochem, La Jolla, California) es un estilbeno de origen [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-42091","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La fosforilaci\u00f3n de serina inducida por resveratrol de p53 causa apoptosis en una l\u00ednea celular mutante de c\u00e1ncer de pr\u00f3stata p53&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=42091\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La fosforilaci\u00f3n de serina inducida por resveratrol de p53 causa apoptosis en una l\u00ednea celular mutante de c\u00e1ncer de pr\u00f3stata p53&quot; -\" \/>\n<meta property=\"og:description\" content=\"Lin, H. Y., Shih, A. I., Davis, F. B., Tang, H. Y., Martino, L. J., Bennett, J. A., &amp; Davis, P. J. (2002).\u00a0Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line.\u00a0The Journal of urology, 168(2), 748-755.\u00a0 PROP\u00d3SITO: El resveratrol (Calbiochem, La Jolla, California) es un estilbeno de origen [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=42091\" \/>\n<meta property=\"article:published_time\" content=\"2020-06-10T04:30:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-cJrTbbh1pnk\/XuEzox5RhUI\/AAAAAAAAdek\/RR8AKdpFPMMyLA2LnJYdZkjhql48-dQVACLcBGAsYHQ\/s320\/Journal_Urology.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script 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