{"id":42357,"date":"2020-06-17T02:30:18","date_gmt":"2020-06-17T00:30:18","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=42357"},"modified":"2020-06-17T02:30:18","modified_gmt":"2020-06-17T00:30:18","slug":"42357","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=42357","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abContribuci\u00f3n de la v\u00eda del receptor glucocorticoide-mineralocorticoide en la disfunci\u00f3n adipoc\u00edtica relacionada con la obesidad\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-8RRmaPsbW7s\/XunW5CQi6zI\/AAAAAAAAdn4\/kpQR-k0g5GcKy57VfIEOhZsTw5X8IbkKACLcBGAsYHQ\/s1600\/Biochemical_biophysical%2Bresearch%2Bcommunications.gif\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-8RRmaPsbW7s\/XunW5CQi6zI\/AAAAAAAAdn4\/kpQR-k0g5GcKy57VfIEOhZsTw5X8IbkKACLcBGAsYHQ\/s1600\/Biochemical_biophysical%2Bresearch%2Bcommunications.gif\" border=\"0\" data-original-width=\"200\" data-original-height=\"268\" \/><\/a>Hirata, A., Maeda, N., Nakatsuji, H., Hiuge-Shimizu, A., Okada, T., Funahashi, T., &amp; Shimomura, I. (2012).\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0006291X12001933\">Contribution of glucocorticoid\u2013mineralocorticoid receptor pathway on the obesity-related adipocyte dysfunction.<\/a>\u00a0<i>Biochemical and biophysical research communications<\/i>, 419(2), 182-187.<\/p>\n<p>OBJETIVOS: El bloqueo del receptor de mineralocorticoides (MR) mejor\u00f3 la resistencia a la insulina con mejoras en la desregulaci\u00f3n de la adipocitoquina, la inflamaci\u00f3n y el exceso de especies reactivas de ox\u00edgeno (ROS) en el tejido adiposo obeso y los adipocitos, pero su mecanismo no se ha aclarado. La 11\u03b2-hidroxiesteroide deshidrogenasa tipo 1 (11\u03b2-HSD1), que produce glucocorticoides activos, est\u00e1 altamente expresada en adipocitos y glucocorticoides se unen a MR con mayor afinidad que al receptor de glucocorticoides (GR). Investigamos si el efecto de los glucocorticoides en las adipocitocinas y ROS a trav\u00e9s de la RM en los adipocitos. Adem\u00e1s, se investigaron las distribuciones de grasa de MR y GR en sujetos humanos.<\/p>\n<p>M\u00c9TODOS Y RESULTADOS: Los receptores corticoides y sus genes diana se examinaron en tejido adiposo de ratones obesos db \/ db . Adipocitos 3T3-L1 fueron tratados con glucocorticoides, H 2 O 2 , MR antagonista de eplerenona (EP), GR antagonista RU486 (RU), MR-siRNA, y \/ o N-acetilciste\u00edna. Se obtuvieron tejidos adiposos humanos de siete pacientes que se sometieron a cirug\u00eda abdominal. Los niveles de ARNm de MR y su gen objetivo fueron m\u00e1s altos en ratones db \/ db que en ratones control db \/ m +. En los adipocitos 3T3-L1, glucocorticoides, similares a H, caus\u00f3 la desregulaci\u00f3n de los niveles de ARNm de varios genes relacionados con las adipocitocinas y el aumento de ROS intracelulares. Dichos cambios fueron rectificados por bloqueo de MR, no por antagonista de GR. En la grasa humana, el nivel de ARNm de MR aument\u00f3 en paralelo con el aumento del \u00edndice de masa corporal (IMC) y su aumento fue m\u00e1s significativo en la grasa visceral, mientras que no hubo correlaciones aparentes del nivel de ARNm de GR con el IMC o la distribuci\u00f3n de grasa. ratones. En los adipocitos 3T3-L1, glucocorticoides, similar a H 2 O 2, caus\u00f3 la desregulaci\u00f3n de los niveles de ARNm de varios genes relacionados con las adipocitocinas y el aumento de ROS intracelulares. Dichos cambios fueron rectificados por bloqueo de MR, no por antagonista de GR. En la grasa humana, el nivel de ARNm de MR aument\u00f3 en paralelo con el aumento del \u00edndice de masa corporal (IMC) y su aumento fue m\u00e1s significativo en la grasa visceral, mientras que no hubo correlaciones aparentes del nivel de ARNm de GR con el IMC o la distribuci\u00f3n de grasa.<\/p>\n<p>CONCLUSI\u00d3N: La v\u00eda glucocorticoide-MR puede contribuir a la desregulaci\u00f3n de la adipocitoquina relacionada con la obesidad y la ROS adiposa.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hirata, A., Maeda, N., Nakatsuji, H., Hiuge-Shimizu, A., Okada, T., Funahashi, T., &amp; Shimomura, I. (2012).\u00a0Contribution of glucocorticoid\u2013mineralocorticoid receptor pathway on the obesity-related adipocyte dysfunction.\u00a0Biochemical and biophysical research communications, 419(2), 182-187. OBJETIVOS: El bloqueo del receptor de mineralocorticoides (MR) mejor\u00f3 la resistencia a la insulina con mejoras en la desregulaci\u00f3n de la adipocitoquina, la inflamaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-42357","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;Contribuci\u00f3n de la v\u00eda del receptor glucocorticoide-mineralocorticoide en la disfunci\u00f3n adipoc\u00edtica relacionada con la obesidad&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=42357\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;Contribuci\u00f3n de la v\u00eda del receptor glucocorticoide-mineralocorticoide en la disfunci\u00f3n adipoc\u00edtica relacionada con la obesidad&quot; -\" \/>\n<meta property=\"og:description\" content=\"Hirata, A., Maeda, N., Nakatsuji, H., Hiuge-Shimizu, A., Okada, T., Funahashi, T., &amp; Shimomura, I. (2012).\u00a0Contribution of glucocorticoid\u2013mineralocorticoid receptor pathway on the obesity-related adipocyte dysfunction.\u00a0Biochemical and biophysical research communications, 419(2), 182-187. OBJETIVOS: El bloqueo del receptor de mineralocorticoides (MR) mejor\u00f3 la resistencia a la insulina con mejoras en la desregulaci\u00f3n de la adipocitoquina, la inflamaci\u00f3n [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=42357\" \/>\n<meta property=\"article:published_time\" content=\"2020-06-17T00:30:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-8RRmaPsbW7s\/XunW5CQi6zI\/AAAAAAAAdn4\/kpQR-k0g5GcKy57VfIEOhZsTw5X8IbkKACLcBGAsYHQ\/s1600\/Biochemical_biophysical%2Bresearch%2Bcommunications.gif\" \/>\n<meta name=\"author\" content=\"admin2\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin2\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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