{"id":42656,"date":"2020-06-24T03:30:34","date_gmt":"2020-06-24T01:30:34","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=42656"},"modified":"2020-06-24T03:30:34","modified_gmt":"2020-06-24T01:30:34","slug":"42656","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=42656","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abQuercetina y rutina como inhibidores de la neoplasia de colon inducida por azoximetanol\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-mTCsu4pJmu0\/XvJQzZQhSWI\/AAAAAAAAd1E\/A6VHRHHu-E0RmWnNmabHfntUnicj0d0KACLcBGAsYHQ\/s1600\/Carcinogenesis.png\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-mTCsu4pJmu0\/XvJQzZQhSWI\/AAAAAAAAd1E\/A6VHRHHu-E0RmWnNmabHfntUnicj0d0KACLcBGAsYHQ\/s320\/Carcinogenesis.png\" width=\"247\" height=\"320\" border=\"0\" data-original-width=\"520\" data-original-height=\"672\" \/><\/a>Deschner, E. E., Ruperto, J., Wong, G., &amp; Newmark, H. L. (1991).\u00a0<a href=\"https:\/\/academic.oup.com\/carcin\/article-abstract\/12\/7\/1193\/290240\">Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia<\/a>.\u00a0<i>Carcinogenesis<\/i>, 12(7), 1193-1196.<\/p>\n<p>Se proporcionaron quercetina (QU) y rutina (RU) diet\u00e9ticas, flavonoides fen\u00f3licos que se encuentran com\u00fanmente en muchas frutas y verduras, a ratones hembra CF1 durante 50 semanas para evaluar la capacidad de estos compuestos para inhibir la neoplasia de colon inducida por azoximetanol (AOM). Adem\u00e1s de un grupo de control alimentado con una dieta AIN 76A, otros cinco grupos recibieron esa dieta a la que se le a\u00f1adi\u00f3 0.1, 0.5 o 2.0% QU y 1.0 o 4.0% RU.\u00a0<\/p>\n<p>Los estudios agudos revelaron que, entre los controles salinos, no se observ\u00f3 ninguna alteraci\u00f3n de ning\u00fan par\u00e1metro proliferativo de las c\u00e9lulas epiteliales del colon entre aquellos grupos que recibieron cualquier dosis de QU o RU. Sin embargo, entre los ratones tratados con AOM, tanto el 2% de QU como el 4% de RU redujeron significativamente la hiperproliferatlona e inhibieron el desplazamiento de las c\u00e9lulas de la fase S a la porci\u00f3n media y superior de las criptas. Adem\u00e1s, los ratones alimentados con estas concentraciones de QU y RU ten\u00edan significativamente menos \u00e1reas focales de displasia inducidas por AOM (FAD) que aquellos alimentados con la dieta de control (0.2 \u00b1 0.4 y 0.4 \u00b1 0.5 versus 3.6 \u00b1 2.3 respectivamente). Los tumores ocurrieron con mayor frecuencia en la mitad distal del colon, independientemente del tratamiento.\u00a0<\/p>\n<p>En comparaci\u00f3n con los controles, los ratones alimentados con un 2% de QU tuvieron una incidencia tumoral significativamente reducida (25.0% versus 5.9%,P = 0,03). Los alimentados con 4% de RU mostraron solo una tendencia hacia la inhibici\u00f3n (25% versus 9.7%, P = 0.11). Sin embargo, tanto el 2% de QU como el 4% de RU suprimieron la multiplicidad tumoral, es decir, surgieron menos tumores \/ animal en estos grupos que en los ratones de control tratados con AOM (1.2 frente a 2.3, P = 0.005; 1.1 frente a 2.3, P = 0.003 respectivamente).\u00a0<\/p>\n<p>Claramente, QU y RU exhiben actividad significativa en la reducci\u00f3n de hiperproilferatlon inducido por AOM de c\u00e9lulas epiteliales de colon e incidencia de FAD. Este comportamiento pronostic\u00f3 con \u00e9xito la capacidad de ambos flavonoides para suprimir la multiplicidad tumoral y, en \u00faltima instancia, el desarrollo tumoral.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Deschner, E. E., Ruperto, J., Wong, G., &amp; Newmark, H. L. (1991).\u00a0Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia.\u00a0Carcinogenesis, 12(7), 1193-1196. Se proporcionaron quercetina (QU) y rutina (RU) diet\u00e9ticas, flavonoides fen\u00f3licos que se encuentran com\u00fanmente en muchas frutas y verduras, a ratones hembra CF1 durante 50 semanas para evaluar la capacidad de estos compuestos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-42656","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Quercetina y rutina como inhibidores de la neoplasia de colon inducida por azoximetanol&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=42656\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Quercetina y rutina como inhibidores de la neoplasia de colon inducida por azoximetanol&quot; -\" \/>\n<meta property=\"og:description\" content=\"Deschner, E. E., Ruperto, J., Wong, G., &amp; Newmark, H. L. (1991).\u00a0Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia.\u00a0Carcinogenesis, 12(7), 1193-1196. 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