{"id":42700,"date":"2020-06-25T00:30:52","date_gmt":"2020-06-24T22:30:52","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=42700"},"modified":"2020-08-02T13:56:48","modified_gmt":"2020-08-02T11:56:48","slug":"42700","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=42700","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abAsociaciones gen\u00f3micas de la variaci\u00f3n del microbioma intestinal humano e implicaciones para los an\u00e1lisis de inferencia causal\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-2whaip1e9Cg\/XvM3zCqIgQI\/AAAAAAAAd2k\/j5gh4u8PKJwaEkRBuyc1yft-1qU4sJjlwCLcBGAsYHQ\/s1600\/Nature_Microbiology.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-2whaip1e9Cg\/XvM3zCqIgQI\/AAAAAAAAd2k\/j5gh4u8PKJwaEkRBuyc1yft-1qU4sJjlwCLcBGAsYHQ\/s1600\/Nature_Microbiology.jpg\" border=\"0\" data-original-width=\"196\" data-original-height=\"257\" \/><\/a>Hughes, D. A., &amp; BR, W. J. (2020).\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41564-020-0743-8\">Genome-wide associations of human gut microbiome variation and causal inference analyses<\/a>.\u00a0<i>Nat Microbiol<\/i>.<\/p>\n<p>Los estudios cl\u00ednicos recientes y basados \u200b\u200ben la poblaci\u00f3n han identificado una variedad de factores asociados con la variaci\u00f3n del microbioma intestinal humano. Rasgo cuantitativo murino loci, estudios de gemelos humanos y estudios de asociaci\u00f3n de todo el genoma del microbioma han proporcionado evidencia de contribuciones gen\u00e9ticas a la composici\u00f3n de microbiomas. A pesar de esto, todav\u00eda existe una superposici\u00f3n pobre en la asociaci\u00f3n gen\u00e9tica entre los estudios en humanos.<\/p>\n<p>Utilizando modelos espec\u00edficos de tax\u00f3n apropiados, junto con el apoyo de cohortes independientes, mostramos una asociaci\u00f3n entre el genotipo del hu\u00e9sped humano y la variaci\u00f3n del microbioma intestinal. Tambi\u00e9n sugerimos que la interpretaci\u00f3n de los an\u00e1lisis aplicados utilizando asociaciones gen\u00e9ticas se complica por la probable superposici\u00f3n entre las contribuciones gen\u00e9ticas y los componentes heredables del entorno del hu\u00e9sped. Utilizando secuencias de genes de ARN ribos\u00f3mico fecal 16S y datos del genotipo del hu\u00e9sped del Proyecto Flamenco Gut Flora ( n \u2009= 2,223) y dos cohortes alemanas (FoCus, n \u2009= 950; PopGen, n\u2009= 717), identificamos asociaciones gen\u00e9ticas que involucran m\u00faltiples rasgos microbianos.<\/p>\n<p>Dos de estas asociaciones alcanzaron un umbral de nivel de estudio de P \u2009= 1.57 \u00d7 10 \u221210 ; una asociaci\u00f3n entre Ruminococcus y rs150018970 cerca de RAPGEF1 en el cromosoma 9, y entre Coprococcus y rs561177583 dentro de LINC01787 en el cromosoma 1. Se llevaron a cabo an\u00e1lisis exploratorios utilizando otras 11 asociaciones de todo el genoma con fuerte evidencia de asociaci\u00f3n ( P \u2009&lt;2.5 \u00d7 10 \u22128 ) y una se\u00f1al de asociaci\u00f3n previamente informada entre rs4988235 ( MCM6 \/ LCT) y Bifidobacterium . En estos 14 polimorfismos de un solo nucle\u00f3tido hubo evidencia de superposici\u00f3n de se\u00f1ales con otros estudios de asociaci\u00f3n de todo el genoma, incluidos los de la edad en la menarca y los rasgos cardiometab\u00f3licos.<\/p>\n<p>El an\u00e1lisis de aleatorizaci\u00f3n mendeliana pudo estimar las asociaciones entre los rasgos microbianos y la enfermedad (incluyendo Bifidobacterium y composici\u00f3n corporal); sin embargo, en ausencia de efectos claros impulsados \u200b\u200bpor el microbioma, se necesita precauci\u00f3n en la interpretaci\u00f3n.<\/p>\n<p>En general, este trabajo marca un creciente cat\u00e1logo de asociaciones gen\u00e9ticas que proporcionar\u00e1n informaci\u00f3n sobre la contribuci\u00f3n del genotipo del hu\u00e9sped al microbioma intestinal. A pesar de esto, el origen incierto de las se\u00f1ales de asociaci\u00f3n probablemente complicar\u00e1 el trabajo futuro que busca diseccionar la funci\u00f3n o usar asociaciones para el an\u00e1lisis de inferencia causal.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hughes, D. A., &amp; BR, W. J. (2020).\u00a0Genome-wide associations of human gut microbiome variation and causal inference analyses.\u00a0Nat Microbiol. Los estudios cl\u00ednicos recientes y basados \u200b\u200ben la poblaci\u00f3n han identificado una variedad de factores asociados con la variaci\u00f3n del microbioma intestinal humano. Rasgo cuantitativo murino loci, estudios de gemelos humanos y estudios de asociaci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-42700","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;Asociaciones gen\u00f3micas de la variaci\u00f3n del microbioma intestinal humano e implicaciones para los an\u00e1lisis de inferencia causal&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=42700\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;Asociaciones gen\u00f3micas de la variaci\u00f3n del microbioma intestinal humano e implicaciones para los an\u00e1lisis de inferencia causal&quot; -\" \/>\n<meta property=\"og:description\" content=\"Hughes, D. A., &amp; BR, W. J. (2020).\u00a0Genome-wide associations of human gut microbiome variation and causal inference analyses.\u00a0Nat Microbiol. Los estudios cl\u00ednicos recientes y basados \u200b\u200ben la poblaci\u00f3n han identificado una variedad de factores asociados con la variaci\u00f3n del microbioma intestinal humano. Rasgo cuantitativo murino loci, estudios de gemelos humanos y estudios de asociaci\u00f3n de [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=42700\" \/>\n<meta property=\"article:published_time\" content=\"2020-06-24T22:30:52+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-08-02T11:56:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-2whaip1e9Cg\/XvM3zCqIgQI\/AAAAAAAAd2k\/j5gh4u8PKJwaEkRBuyc1yft-1qU4sJjlwCLcBGAsYHQ\/s1600\/Nature_Microbiology.jpg\" \/>\n<meta name=\"author\" content=\"admin2\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin2\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=42700#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=42700\"},\"author\":{\"name\":\"admin2\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/aa08ffbfb4b03539e1fcb74c7ef5c788\"},\"headline\":\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abAsociaciones gen\u00f3micas de la variaci\u00f3n del microbioma intestinal humano e implicaciones para los an\u00e1lisis de inferencia causal\u00bb\",\"datePublished\":\"2020-06-24T22:30:52+00:00\",\"dateModified\":\"2020-08-02T11:56:48+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=42700\"},\"wordCount\":458,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"articleSection\":[\"Naturopat\u00eda Descriptiva\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=42700#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=42700\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?p=42700\",\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \\\"Asociaciones gen\u00f3micas de la variaci\u00f3n del microbioma intestinal humano e implicaciones para los an\u00e1lisis de inferencia causal\\\" -\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\"},\"datePublished\":\"2020-06-24T22:30:52+00:00\",\"dateModified\":\"2020-08-02T11:56:48+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=42700#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=42700\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=42700#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/rina.naturopatiadigital.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abAsociaciones gen\u00f3micas de la variaci\u00f3n del microbioma intestinal humano e implicaciones para los an\u00e1lisis de inferencia causal\u00bb\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"name\":\"\",\"description\":\"Red Investigaci\u00f3n Naturop\u00e1tica\",\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\",\"name\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"contentUrl\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"width\":960,\"height\":960,\"caption\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\"},\"image\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/aa08ffbfb4b03539e1fcb74c7ef5c788\",\"name\":\"admin2\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/5fee9a4d023c1e8791d16bdcacf61d33dfc19c9ac7f05177a8df3bf943ee46e5?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/5fee9a4d023c1e8791d16bdcacf61d33dfc19c9ac7f05177a8df3bf943ee46e5?s=96&d=mm&r=g\",\"caption\":\"admin2\"},\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?author=2\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \"Asociaciones gen\u00f3micas de la variaci\u00f3n del microbioma intestinal humano e implicaciones para los an\u00e1lisis de inferencia causal\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=42700","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \"Asociaciones gen\u00f3micas de la variaci\u00f3n del microbioma intestinal humano e implicaciones para los an\u00e1lisis de inferencia causal\" -","og_description":"Hughes, D. A., &amp; BR, W. J. (2020).\u00a0Genome-wide associations of human gut microbiome variation and causal inference analyses.\u00a0Nat Microbiol. Los estudios cl\u00ednicos recientes y basados \u200b\u200ben la poblaci\u00f3n han identificado una variedad de factores asociados con la variaci\u00f3n del microbioma intestinal humano. Rasgo cuantitativo murino loci, estudios de gemelos humanos y estudios de asociaci\u00f3n de [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=42700","article_published_time":"2020-06-24T22:30:52+00:00","article_modified_time":"2020-08-02T11:56:48+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/-2whaip1e9Cg\/XvM3zCqIgQI\/AAAAAAAAd2k\/j5gh4u8PKJwaEkRBuyc1yft-1qU4sJjlwCLcBGAsYHQ\/s1600\/Nature_Microbiology.jpg"}],"author":"admin2","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin2","Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=42700#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=42700"},"author":{"name":"admin2","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/aa08ffbfb4b03539e1fcb74c7ef5c788"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abAsociaciones gen\u00f3micas de la variaci\u00f3n del microbioma intestinal humano e implicaciones para los an\u00e1lisis de inferencia causal\u00bb","datePublished":"2020-06-24T22:30:52+00:00","dateModified":"2020-08-02T11:56:48+00:00","mainEntityOfPage":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=42700"},"wordCount":458,"commentCount":0,"publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"articleSection":["Naturopat\u00eda Descriptiva"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rina.naturopatiadigital.eu\/?p=42700#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=42700","url":"https:\/\/rina.naturopatiadigital.eu\/?p=42700","name":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \"Asociaciones gen\u00f3micas de la variaci\u00f3n del microbioma intestinal humano e implicaciones para los an\u00e1lisis de inferencia causal\" -","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#website"},"datePublished":"2020-06-24T22:30:52+00:00","dateModified":"2020-08-02T11:56:48+00:00","breadcrumb":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=42700#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rina.naturopatiadigital.eu\/?p=42700"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=42700#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/rina.naturopatiadigital.eu\/"},{"@type":"ListItem","position":2,"name":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abAsociaciones gen\u00f3micas de la variaci\u00f3n del microbioma intestinal humano e implicaciones para los an\u00e1lisis de inferencia causal\u00bb"}]},{"@type":"WebSite","@id":"https:\/\/rina.naturopatiadigital.eu\/#website","url":"https:\/\/rina.naturopatiadigital.eu\/","name":"","description":"Red Investigaci\u00f3n Naturop\u00e1tica","publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/rina.naturopatiadigital.eu\/#organization","name":"Organizaci\u00f3n Colegial Naturop\u00e1tica","url":"https:\/\/rina.naturopatiadigital.eu\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/","url":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","contentUrl":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","width":960,"height":960,"caption":"Organizaci\u00f3n Colegial Naturop\u00e1tica"},"image":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/aa08ffbfb4b03539e1fcb74c7ef5c788","name":"admin2","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/5fee9a4d023c1e8791d16bdcacf61d33dfc19c9ac7f05177a8df3bf943ee46e5?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/5fee9a4d023c1e8791d16bdcacf61d33dfc19c9ac7f05177a8df3bf943ee46e5?s=96&d=mm&r=g","caption":"admin2"},"url":"https:\/\/rina.naturopatiadigital.eu\/?author=2"}]}},"_links":{"self":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/42700","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=42700"}],"version-history":[{"count":1,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/42700\/revisions"}],"predecessor-version":[{"id":43336,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/42700\/revisions\/43336"}],"wp:attachment":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=42700"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=42700"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=42700"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}