{"id":42740,"date":"2020-07-03T05:30:17","date_gmt":"2020-07-03T05:30:17","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=42740"},"modified":"2020-07-04T13:55:07","modified_gmt":"2020-07-04T13:55:07","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-quercetina-regula-el-transportador-de-iones-organicos-y-la-expresion-de-uromodulina-y-mejora-la-funcion-renal-en-ratones-hip","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=42740","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa quercetina regula el transportador de iones org\u00e1nicos y la expresi\u00f3n de uromodulina y mejora la funci\u00f3n renal en ratones hiperuricemicos\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-zxa4fKrBymM\/XwCGLBGf4kI\/AAAAAAAAeHs\/SWFpEByCQ5gNXLYMzk3owkDQgHONDDRvACLcBGAsYHQ\/s1600\/European_Journal_Nutrition.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-zxa4fKrBymM\/XwCGLBGf4kI\/AAAAAAAAeHs\/SWFpEByCQ5gNXLYMzk3owkDQgHONDDRvACLcBGAsYHQ\/s320\/European_Journal_Nutrition.jpg\" width=\"235\" height=\"320\" border=\"0\" data-original-width=\"306\" data-original-height=\"416\" \/><\/a>Hu, Q. H., Zhang, X., Wang, X., Jiao, R. Q., &amp; Kong, L. D. (2012).\u00a0<a href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs00394-011-0243-y\">Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice<\/a>.\u00a0<i>European journal of nutrition<\/i>, 51(5), 593-606.<\/p>\n<p>ANTECEDENTES: Los transportadores de iones org\u00e1nicos renales y la uromodulina (UMOD) juegan un papel importante en la funci\u00f3n y la excreci\u00f3n renal de urato. La hiperuricemia se considera un factor de riesgo para el desarrollo de disfunci\u00f3n renal. La quercetina flavonoide en las dietas ejerce los efectos hipouricemic y nefroprotectores.<\/p>\n<p>PROP\u00d3SITOS: Evaluar los efectos de la quercetina en los transportadores de iones org\u00e1nicos renales y UMOD en ratones hiperuricemicos.<\/p>\n<p>M\u00c9TODOS: Los ratones Kun-Ming se dividieron en grupos normales e hiperuricemicos que recibieron agua, 25, 50 y 100 mg \/ kg de quercetina, 5 mg \/ kg de alopurinol, respectivamente. Los ratones hiperuricemicos se calientaron oralmente con 250 mg \/ kg de oxonato diariamente durante 1 semana. La quercetina y el alopurinol se tomaron por v\u00eda oral el d\u00eda en que se administr\u00f3 oxonato o agua 1 h m\u00e1s tarde. Despu\u00e9s de 1 semana, se midieron las concentraciones s\u00e9ricas de \u00e1cido \u00farico, creatinina y nitr\u00f3geno ureico en sangre, excreci\u00f3n de urato y creatinina y excreci\u00f3n fraccional de \u00e1cido \u00farico. Se analizaron los niveles de ARNm y prote\u00ednas del transportador renal de urato 1 (mURAT1), el transportador de glucosa 9 (mGLUT9), el transportador de aniones org\u00e1nicos 1 (mOAT1) y los transportadores org\u00e1nicos de cationes \/ carnitinas (mOCT1, mOCT2, mOCTN1 y mOCTN2) en ratones. Simult\u00e1neamente, se detectaron los niveles de UMOD en suero, orina y ri\u00f1\u00f3n, as\u00ed como la expresi\u00f3n de ARNm de UMOD renal.<\/p>\n<p>RESULTADOS: La quercetina restableci\u00f3 significativamente las anormalidades inducidas por el oxonato de estos \u00edndices bioqu\u00edmicos en comparaci\u00f3n con el grupo de veh\u00edculos normales. Adem\u00e1s, evit\u00f3 notablemente los cambios de expresi\u00f3n de los transportadores de iones org\u00e1nicos renales y UMOD, y la alteraci\u00f3n del nivel de UMOD en ratones hiperuricemicos.<\/p>\n<p>CONCLUSIONES: Estos resultados sugieren que la quercetina tiene las acciones uricos\u00faricas y nefroprotectoras mediadas por la regulaci\u00f3n de los niveles de expresi\u00f3n de los transportadores de iones org\u00e1nicos renales y UMOD.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hu, Q. H., Zhang, X., Wang, X., Jiao, R. Q., &amp; Kong, L. D. (2012).\u00a0Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice.\u00a0European journal of nutrition, 51(5), 593-606. ANTECEDENTES: Los transportadores de iones org\u00e1nicos renales y la uromodulina (UMOD) juegan un papel importante en la funci\u00f3n y la excreci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-42740","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La quercetina regula el transportador de iones org\u00e1nicos y la expresi\u00f3n de uromodulina y mejora la funci\u00f3n renal en ratones hiperuricemicos&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=42740\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La quercetina regula el transportador de iones org\u00e1nicos y la expresi\u00f3n de uromodulina y mejora la funci\u00f3n renal en ratones hiperuricemicos&quot; -\" \/>\n<meta property=\"og:description\" content=\"Hu, Q. H., Zhang, X., Wang, X., Jiao, R. Q., &amp; Kong, L. D. (2012).\u00a0Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice.\u00a0European journal of nutrition, 51(5), 593-606. ANTECEDENTES: Los transportadores de iones org\u00e1nicos renales y la uromodulina (UMOD) juegan un papel importante en la funci\u00f3n y la excreci\u00f3n [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=42740\" \/>\n<meta property=\"article:published_time\" content=\"2020-07-03T05:30:17+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-07-04T13:55:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-zxa4fKrBymM\/XwCGLBGf4kI\/AAAAAAAAeHs\/SWFpEByCQ5gNXLYMzk3owkDQgHONDDRvACLcBGAsYHQ\/s320\/European_Journal_Nutrition.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script 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