{"id":42762,"date":"2020-07-04T05:30:06","date_gmt":"2020-07-04T05:30:06","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=42762"},"modified":"2020-07-04T19:06:27","modified_gmt":"2020-07-04T19:06:27","slug":"area-de-conocimiento-naturopatia-descriptiva-la-angiotensina-1-7-previene-el-desgaste-del-musculo-esqueletico-inducido-por-endotoxina-mediante-un-mecanismo-dependiente-de-mapk-p38","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=42762","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abLa angiotensina- (1-7) previene el desgaste del m\u00fasculo esquel\u00e9tico inducido por endotoxina mediante un mecanismo dependiente de MAPK p38\u00bb"},"content":{"rendered":"

<\/a>Morales, M. G., Olgu\u00edn, H., Di Capua, G., Brandan, E., Simon, F., & Cabello-Verrugio, C. (2015).\u00a0Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1\u20137) through a p38 MAPK-dependent mechanism.<\/a>\u00a0Clinical science<\/i>, 129(6), 461-476.<\/p>\n

La atrofia del m\u00fasculo esquel\u00e9tico inducida durante el s\u00edndrome de sepsis producido por la endotoxina en forma de LPS (lipopolisac\u00e1rido), es una condici\u00f3n patol\u00f3gica caracterizada por la p\u00e9rdida de fuerza y \u200b\u200bmasa muscular, un aumento en la degradaci\u00f3n del MHC (cadena pesada de miosina) y un aumento en la expresi\u00f3n de atrogin-1 y MuRF-1 (prote\u00edna 1 de dedo RING espec\u00edfica de m\u00fasculo), dos ligasas de ubiquitina E3 que pertenecen al sistema ubiquitina-proteasoma. Ang- (1-7) [Angiotensina- (1-7)], a trav\u00e9s de su receptor Mas, tiene efectos beneficiosos en el m\u00fasculo esquel\u00e9tico.<\/p>\n

Evaluamos in vivo el papel del receptor Ang- (1-7) y el receptor Mas en el desgaste muscular inducido por la inyecci\u00f3n de LPS en ratones C57BL \/ 10J. Se realizaron estudios in vitro en miotubos C2C12 murinos y miofibras aisladas del m\u00fasculo EDL (extensor largo de los dedos). Adicionalmente, Se evalu\u00f3 la participaci\u00f3n de p38 MAPK (prote\u00edna quinasa activada por mit\u00f3geno) en el efecto Ang- (1-7) sobre la atrofia muscular inducida por LPS.<\/p>\n

Nuestros resultados muestran que Ang- (1-7) previene la disminuci\u00f3n del di\u00e1metro de miofibras y miotubos, la disminuci\u00f3n de la fuerza muscular, la disminuci\u00f3n de los niveles de MHC y la inducci\u00f3n de la expresi\u00f3n de atrogin-1 y MuRF-1, todos los cuales son inducido por LPS. Estos efectos fueron revertidos usando A779, un antagonista de Mas. Ang- (1-7) ejerce estos efectos antiatr\u00f3ficos al menos en parte al inhibir la activaci\u00f3n dependiente de LPS de p38 MAPK tanto in vitro como in vivo.<\/p>\n

Hemos demostrado por primera vez que Ang- (1-7) contrarresta la atrofia del m\u00fasculo esquel\u00e9tico inducida por la endotoxina a trav\u00e9s de un mecanismo dependiente del receptor Mas que implica una disminuci\u00f3n en la fosforilaci\u00f3n de p38 MAPK.<\/p>\n","protected":false},"excerpt":{"rendered":"

Morales, M. G., Olgu\u00edn, H., Di Capua, G., Brandan, E., Simon, F., & Cabello-Verrugio, C. (2015).\u00a0Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1\u20137) through a p38 MAPK-dependent mechanism.\u00a0Clinical science, 129(6), 461-476. La atrofia del m\u00fasculo esquel\u00e9tico inducida durante el s\u00edndrome de sepsis producido por la endotoxina en forma de LPS (lipopolisac\u00e1rido), es una condici\u00f3n patol\u00f3gica […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-42762","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"\n\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva "La angiotensina- (1-7) previene el desgaste del m\u00fasculo esquel\u00e9tico inducido por endotoxina mediante un mecanismo dependiente de MAPK p38" -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=42762\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva "La angiotensina- (1-7) previene el desgaste del m\u00fasculo esquel\u00e9tico inducido por endotoxina mediante un mecanismo dependiente de MAPK p38" -\" \/>\n<meta property=\"og:description\" content=\"Morales, M. G., Olgu\u00edn, H., Di Capua, G., Brandan, E., Simon, F., & Cabello-Verrugio, C. (2015).\u00a0Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1\u20137) through a p38 MAPK-dependent mechanism.\u00a0Clinical science, 129(6), 461-476. La atrofia del m\u00fasculo esquel\u00e9tico inducida durante el s\u00edndrome de sepsis producido por la endotoxina en forma de LPS (lipopolisac\u00e1rido), es una condici\u00f3n patol\u00f3gica […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=42762\" \/>\n<meta property=\"article:published_time\" content=\"2020-07-04T05:30:06+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-07-04T19:06:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-h3kYTSvBDl8\/XwDSy3l2PBI\/AAAAAAAAeI4\/WQQM5yH5yYsXNLeE9Ixqhc3pj8eH99JDACLcBGAsYHQ\/s1600\/Clinical_science.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" 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